RESUMEN
"Growing pains" are a frequent problem in paediatric practice. Over the last years, their diagnostic and therapeutic approaches have changed. Other syndromes than those well-known by paediatricians are to be taken in consideration. Current treatment consists in reassurance of children and their family reactivation of patients (which means to take up a normal physical activity) and treatment of painful crisis as well as complementary therapies.
Asunto(s)
Crecimiento , Dolor , Adolescente , Adulto , Factores de Edad , Niño , Preescolar , Consejo , Trastornos de Traumas Acumulados/diagnóstico , Diagnóstico Diferencial , Ejercicio Físico , Femenino , Fibromialgia/diagnóstico , Crecimiento/fisiología , Humanos , Lactante , Recién Nacido , Masculino , Enfermedades Musculoesqueléticas/diagnóstico , Dolor/diagnóstico , Dolor/tratamiento farmacológico , Manejo del Dolor , Dimensión del Dolor , Síndrome de las Piernas Inquietas/diagnóstico , Encuestas y CuestionariosRESUMEN
UNLABELLED: Neonates with Down's syndrome have an increased risk for congenital leukaemia, particularly acute megakaryoblastic leukaemia (FAB, M7) which most often resolves spontaneously and is called transient leukaemia. It can be observed in non-constitutional trisomy 21 infants then presenting trisomy 21 on blasts cells. OBSERVATION: We report a transient leukaemia with an isolated pericardial effusion in a phenotypically normal neonate. Trisomy 21 was found on blasts cells. Complete remission remains after 32 months. DISCUSSION: Congenital leukaemias, with trisomy 21 on blasts cells have a good prognosis that justifies observation before using chemotherapy.
Asunto(s)
Síndrome de Down/complicaciones , Leucemia Megacarioblástica Aguda/congénito , Antígenos CD/análisis , Síndrome de Down/patología , Humanos , Lactante , Leucemia Megacarioblástica Aguda/patología , Masculino , Remisión EspontáneaRESUMEN
From 1999 to 2002, 246 serum samples taken from polytransfused children were tested for the presence of GB virus C (GBV-C) RNA using a real-time reverse transcription-polymerase chain reaction (RT-PCR) assay. This assay was based on the TaqMan technology and allowed viral load determination in infected children with a dynamic range from 10(3) to 10(7) genome equivalent (gEq) copies/ml. The limit of detection was estimated to 619 gEq copies/ml with a > or = 95% probability of a positive result. Thirty five sera were found to be GBV-C RNA positive, corresponding to a prevalence of GBV-C of 14.2%. The mean viral load was high, i.e., 6 +/- 1.4 log (range 3.22-7.42) gEq copies/ml, but low viral loads were also detected. Sequencing of the 5'-untranslated region (UTR) identified a majority of genotype 2 strains (82%) distributed into two subtypes, 88.5% genotype 2a and 11.5% genotype 2b. In conclusion, GBV-C active infection is very frequent in exposed populations such as polytransfused children. GBV-C RNA quantitation using real-time assay may be useful for diagnosis and follow-up of the natural history of GBV-C infection.