RESUMEN
Cutaneous squamous cell carcinoma (cSCC) manifests through the complex interactions of UV-induced DNA damage, genetic mutations, and alterations in the tumor microenvironment. A high mutational burden is present in cSCC, as well as both cSCC precursors and normal skin, making driver genes difficult to differentiate. Despite this, several key driver genes have been identified, including TP53, the NOTCH family, CDKN2A, PIK3CA, and EGFR. In addition to mutations, the tumor microenvironment and the manipulation and evasion of the immune system play a critical role in cSCC progression. Novel therapeutic approaches, such as immunotherapy and EGFR inhibitors, have been used to target these dysregulations, and have shown promise in treating advanced cSCC cases, emphasizing the need for targeted interventions considering both genetic and microenvironmental factors for improved patient outcomes.
RESUMEN
The recovery of value-added materials from coal ash waste is of highly economic value and sustainable significance. However, researches on the synthesis of defect-engineering nanomaterials from coal ash are still blank. Herein, iron oxide (Fe1.72Al0.28O3, simplified as FAO) nanoflakes were successfully synthesized from a brown coal fly ash (BCFA) waste. The obtained FAO nanoflakes possess a round-shape morphology with a diameter of around 300 nm and 50 nm in thickness. With the progress of hydrothermal treatment, the impure Al3+ gradually replaced part of the Fe3+ in the α-Fe2O3 crystal. Specifically, Al3+ was preferentially adsorbed on the (001) facet, hindering the growth of Fe3+ on the [001] direction and thus causing the flattening of the resultant FAO. The introduced Al3+ also serves as the disordered defects on the hematite surface, leading to decreased crystal parameters for hematite, the formation of a compact first shell and a reduced periodical symmetry for the central cation Fe3+. The defects were also found to significantly improve the adsorption capacity of the resultant FAO for Cr(VI), As(V), As(III) and Congo red in waste water, with the maximum adsorption capacity of 68.3, 80.6, 61.1 and 213.8 mg g-1, respectively. Cyclic tests also confirmed a relatively strong stability for the as-synthesised adsorbents.
RESUMEN
BACKGROUND: Application of hemostatic agents can negatively affect the bond strength of adhesive systems to dental substrate. This study aimed to assess the effect of ferric sulfate on microshear bond strength of four total- and self-etch adhesives to dentin after water storage. MATERIALS AND METHODS: In this in vitro study, 192 dentin slices with 2 mm thickness were made of 64 extracted sound human third molars. The samples were divided into 8 groups (n = 24) as follows: G1: Scotchbond Multi-Purpose, G2: hemostatic agent + Scotchbond, G3: Adper Single Bond, G4: hemostatic agent + Adper, G5: Clearfil SE Bond, G6: hemostatic agent + Clearfil, G7: Single Bond Universal, and G8: hemostatic agent + Single Bond Universal. Composite cylinders with 0.7 mm diameter and 1 mm height were bonded to the surfaces. Each group was then divided into two subgroups (n = 12) for water storage for 24 h and 3 months. The microshear bond strength was then measured. Data were analyzed using the Shapiro-Wilk test, three-way ANOVA, one-way ANOVA, and Tukey's test (P < 0.05). RESULTS: Application of ferric sulfate decreased the bond strength of all bonding agents after both 24 h and 3 months of storage; but, this reduction was not statistically significant (P > 0.05). Single Bond Universal at 24 h showed the highest and Adper Single Bond at 3 months showed the lowest bond strength (P < 0.001). CONCLUSION: Dentin contamination with hemostatic agents negatively affects the bond strength of total- and self-etch adhesives.