Vestibular rehabilitation in cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS)- A case report.

Background and purpose: Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) is a neurodegenerative disease of the cerebellum. The disease progression is slow, with up to 25% of people diagnosed needing to use a wheelchair after 15 years from diagnosis. Vestibular symptoms arise from centrally-mediated ocular movement degradation and the reduced vestibular-ocular reflex functioning bilaterally. To date, no report has shown an improvement in VOR gain or gait outcome measures in someone with CANVAS after a course of vestibular physical therapy. Case description: A 65-year-old male, Patient X, first noticed symptoms in his fourth decade of life and was diagnosed with (CANVAS) in his seventh decade. Patient X reported numbness and tingling in his hands and feet, decreased ability to perform daily activities, and several falls. Intervention: Patient X completed a four-month course of vestibular physical therapy, including vestibular ocular reflex exercises, balance training, gait training, and the VestAid application for eye gaze compliance monitoring. The Vestaid application uses eyes and facial recognition software to record the percentage of time that the patient kept their eyes on the target. Outcomes: After vestibular therapy, Patient X had a clinically meaningful improvement in gait speed: from 1.02 m/s to 1.13 m/s and in the Functional Gait Assessment from 20/30 to 27/30. Patient X's eye gaze compliance improved from a median of 43% (range 25-68%) to a median of 67% (58-83%). Discussion: This case study demonstrates that vestibular rehabilitation improved eye gaze compliance and functional outcomes in a person living with CANVAS.

Administration of estradiol benzoate before insemination could skew secondary sex ratio toward males in Holstein dairy cows.

The present study was conducted to investigate the effect of estradiol benzoate administration before insemination on secondary sex ratio (proportion of male calves at birth) in Holstein dairy cows. Cows (n = 1,647) were randomly assigned to 2 experimental groups by parity over a 1-yr period. Cows in the control group (n = 827; 232 primiparous and 595 multiparous cows) received 2 administrations of PGF2α (500 µg) 14 d apart, started at 30 to 35 d postpartum. Twelve d after the second PGF2α injection, cows received GnRH (100 µg), followed by administration of PGF2α 7 d later. Cows in the treatment group (n = 820; 238 primiparous and 582 multiparous cows) received the same hormonal administrations as the cows in the control group. Additionally, cows in the treatment group received estradiol benzoate (1 mg) 1 d after the third PGF2α injection. Estrus detection by visual observation was started 1 d after the third PGF2α injection and after estradiol administration in the control (for 6 d) and treatment (for 36 h) groups, respectively. Artificial insemination was carried out 12 h after observation of standing estrus. Exposure of cows to heat stress at conception was determined based on temperature-humidity index. Estrus detection rate was lower in primiparous than in multiparous cows (P < 0.05), but conception rate was higher in primiparous vs multiparous cows (P < 0.05). Estradiol administration improved estrus detection rate and fertility (P < 0.05); moreover, it increased secondary sex ratio (adjusted odds ratio: 1.645; P = 0.017). Exposure to heat stress diminished heat detection rate and fertility (P < 0.05), and altered secondary sex ratio toward males (adjusted odds ratio: 2.863; P = 0.012). In conclusion, the present study revealed that estradiol administration before insemination could improve fertility and increase the probability of calves being male in Holstein dairy cows. Moreover, the results showed that cows exposed to heat stress around conception had diminished fertility and increased secondary sex ratio.

The effect of different doses of gonadorelin on ovarian follicle dynamics in river buffalo (Bubalus bubalis).

The objective of this study was to determine the response of the ovarian dominant follicle to the different doses of GnRH in river buffalo. The estrous cycle of 12 river bufflaloes was synchronized using norgestomet implant for 12 days in association with two injections of prostaglandin F2alpha analogue on Days 0 and 7 of implant insertion. On Day 6 or 7 of the ensuing cycle (Day 0 of the experiment), females received a norgestomet implant in conjunction with two prostaglandin injections on Days 0 and 1. On Day 6 of the experiment, females were randomly allocated into three groups. At this time, Group 1 and 2 females were given an i.m. injection of 50 or 100 microg Gonadorelin, respectively. Group 3 females did not receive any further treatment and were considered as control. All females were given prostaglandin on Day 12 and implants were removed on Day 13 of the experiment. The results revealed that in the control group, ovarian dominant follicle became persistent throughout the experiment; whereas, the persistent dominant follicle in all females belonging to Group 2 (100 microg GnRH) and one female in Group 1 (50 microg GnRH) ovulated within 48 h, subsequent with an emergence of a new follicular wave and an increase in plasma progesterone concentration within 72 and 96 h after GnRH injection, respectively. In conclusion, 100 microg of Gonadorelin seems to be the most effective dose to induce ovulation followed by an emergence of a new follicular wave in river buffalo.

Factors associated with rectovaginal injuries in Holstein dairy cows in a herd in Tehran, Iran.

Rectovaginal injuries can result in subsequent infertility in cows. In a retrospective study, records of 147 Holstein cows with evidence of rectovaginal injuries were reviewed to determine the odds ratio (OR) of these injuries and their related risk factors. The study was conducted in a large dairy (typical herd size 1420 cows) in Tehran between the years 1993 and 1996. Period prevalences were 0.4% fistula, 1.9% laceration (third degree), 5.7% pneumovagina, 1.5% urovagina and 0.8% mixed injuries. The highest risk occurred among first-calf heifers. Animals with dystocia, first-calf heifers and male calves were at higher risk for rectovaginal injuries. We concluded that (1) handling dystocia with care might have a substantial role in reducing rectovaginal injuries, (2) first-calf heifers are to be under close observation and care during calving, and (3) because rectovaginal injuries reoccur in the next calving, cows with the history of these injuries should be monitored at the next labor.