Creating Anti-Chiral Exceptional Points in Non-Hermitian Metasurfaces for Efficient Terahertz Switching.

Non-Hermitian degeneracies, also known as exceptional points (EPs), have presented remarkable singular characteristics such as the degeneracy of eigenvalues and eigenstates and enable limitless opportunities for achieving fascinating phenomena in EP photonic systems. Here, the general theoretical framework and experimental verification of a non-Hermitian metasurface that holds a pair of anti-chiral EPs are proposed as a novel approach for efficient terahertz (THz) switching. First, based on the Pancharatnam-Berry (PB) phase and unitary transformation, it is discovered that the coupling variation of ±1 spin eigenstates will lead to asymmetric modulation in two orthogonal linear polarizations (LP). Through loss-induced merging of a pair of anti-chiral EPs, the decoupling of ±1 spin eigenstates are then successfully realized in a non-Hermitian metasurface. Final, the efficient THz modulation is experimentally demonstrated, which exhibits modulation depth exceeding 70% and Off-On-Off switching cycle less than 9 ps in one LP while remains unaffected in another one. Compared with conventional THz modulation devices, the metadevice shows several figures of merits, such as a single frequency operation, high modulation depth, and ultrafast switching speed. The proposed theory and loss-induced non-Hermitian device are general and can be extended to numerous photonic systems varying from microwave, THz, infrared, to visible light.

In vitro differentiation of human induced pluripotent stem cells into temporomandibular joint disc like cells.

Temporomandibular joint discs (TMJ discs) are unable to repair themselves in disease states, while induced stem cell differentiation is a common method to repair tissue defects. Nowadays, kinds of stem cells are attempted for tissue regeneration of TMJ disc, but these methods have several downsides, which limit their wide application. The proliferation and differentiation ability of human induced pluripotent stem cells (hiPSC) provides a new research direction for TMJ disc tissue regeneration. In this study, we investigated the feasibility of induced differentiation of hiPSC into TMJ disc cells in vitro and the differentiation efficiency of different methods to clarify the possibility and conditions of hiPSC application in TMJ disc tissue engineering. We collected sheep TMJ disc cells cultures for adding in hiPSC culture environment and treated hiPSC by both direct induction and Transwell co-culture for 7 days, 14 days and 21 days. The secretion of extracellular matrix in TMJ disc cells was detected by Sirius Red and Safranin O staining. Collagen Ⅰ and Collagen Ⅱ were qualitatively detected by immunohistochemical staining. The expression of extracellular matrix genes (type I collagen (COL1A1), type II collagen(COL2), glycosaminoglycan (GAG)), chondrogenic differentiation gene SOX9 and pluripotency gene OCT4 were detected by RT-qPCR. Our results showed that hiPSC had the ability to differentiate to TMJ disc cells by direct induction in TMJ disc cell culture medium and by Transwell co-culture method. The highest degree of differentiation was observed after 14 days of direct induction, while Transwell co-culture showed significant differentiation at different times and with different major directions. Meanwhile, Transwell co-culture not only differentiates hiPSC but also promotes the growth and proliferation of TMJ disc cells. Our study is valuable to investigate the possibility of differentiation of hiPSC toward TMJ disc cells and to determine the time of differentiation. It provides new ideas for the selection of seed cells for TMJ disc tissue engineering.

Transient Loss-Induced Non-Hermitian Degeneracies for Ultrafast Terahertz Metadevices.

Non-Hermitian degeneracies, also known as exceptional points (EPs), have attracted considerable attention due to their unique physical properties. In particular, metasurfaces related to EPs can open the way to unprecedented devices with functionalities such as unidirectional transmission and ultra-sensitive sensing. Herein, an active non-Hermitian metasurface with a loss-induced parity-time symmetry phase transition for ultrafast terahertz metadevices is demonstrated. Specifically, the eigenvalues of the non-Hermitian transmission matrix undergo a phase transition under optical excitation and are degenerate at EPs in parameter space, which is accompanied by the collapse of chiral transmission. Ultrafast EP modulation on a picosecond time scale can be realized through variations in the transient loss at a non-Hermitian metasurface pumped by pulsed excitation. Furthermore, by exploiting the physical characteristics of chiral transmission EPs, a switchable quarter-wave plate based on the photoactive metasurface is designed and experimentally verified and realized the corresponding function of polarization manipulation. This work opens promising possibilities for designing functional terahertz metadevices and fuses EP physics with active metasurfaces.

Multi-Objective Topology Optimization of a Broadband Piezoelectric Energy Harvester.

In recent years, topology optimization has proved itself to be state of the art in the design of mechanical structures. At the same time, energy harvesting has gained a lot of attention in research and industry. In this work, we present a novel topology optimization of a multi-resonant piezoelectric energy-harvester device. The goal is to develop a broadband design that can generate constant power output over a range of frequencies, thus enabling reliable operation under changing environmental conditions. To achieve this goal, topology optimization is implemented with a combined-objective function, which tackles both the frequency requirement and the power-output characteristic. The optimization suggests a promising design, with satisfactory frequency characteristics.

Reassessing Fano Resonance for Broadband, High-Efficiency, and Ultrafast Terahertz Wave Switching.

Miniaturized ultrafast switchable optical components with high efficiency and broadband response are in high demand to the development of optical imaging, sensing, and high-speed communication. Sharp Fano-type resonance switched by active materials is one of the key concepts that underpins the control of light in metaoptics with high sensitivity. However, actuating such metasurfaces exhibits a long-standing trade-off between modulation depth and operational bandwidth. Here, the limitations are circumvented by theoretical analysis, numerical simulation, and experimental realization of an achromatic Fano metasurface so that a high contrast of tunability with ultrafast switching rate over a broad range of frequency is achieved. By developing the physics of inter-mode coupling, the Fano metasurface is designed according to a complete phase diagram derived from coupled mode theory. Unlike conventional Fano metasurfaces, the cross-polarized inter-metaatoms coupling is discovered as a superior ability of high-efficiency broadband achromatic polarization conversion. To prove the ultrasensitive nature, a metadevice is constructed by incorporating a thin amorphous Ge layer with a weak photoconductivity perturbation. Transmission modulation over broadband frequency range from 0.6 to 1.1 THz is thus successfully realized, featuring its merits of modulation depth over 90% and On-Off-On switching cycle less than 10 ps.

Analysis and Characterization of Optimized Dual-Frequency Vibration Energy Harvesters for Low-Power Industrial Applications.

We present a multiresonant vibration energy harvester designed for ultra-low-power applications in industrial environments together with an optimized harvester design. The proposed device features dual-frequency operation, enabling the harvesting of energy over a wider operational frequency range. It has been designed such that its harvesting bandwidth range is [50, 100] Hz, which is a typical frequency range for vibrations found in industrial applications. At an excitation level of 0.5 g, a maximum mean power output of 6 mW and 9 mW can be expected at the resonance frequencies of 63.3 and 76.4 Hz, respectively. The harvester delivers a power density of 492 µW/cm2. Design optimization led to improved harvester geometries yielding up to 2.6 times closer resonance frequencies, resulting in a wider harvesting bandwidth and a significantly higher power output.

Light-Driven Spintronic Heterostructures for Coded Terahertz Emission.

The extraordinary proliferation of digital coding metasurfaces turns the real-time manipulation of electromagnetic (EM) waves into reality and promotes the programmable operation of multifunctional equipment. However, current studies are mainly involved in the modulation of the transmission process, and little attention has been given to the control of EM wave generation, especially in the terahertz (THz) band. Here, we conceptually propose and experimentally demonstrate coded terahertz emission, which integrates the efficient generation and control of THz waves across a wide frequency band. For validation, two types of stripe-patterned ferromagnetic heterostructures with opposite spin Hall angles were utilized as coding units. The two distinct states in each coding unit (with two polarization or phase states of 0° and 180°) can be characterized as "0" and "1" digits, which can be switched by manipulating the optical field distribution of the pump beam. Such an ability to realize simultaneous terahertz coding and terahertz emission is essential for meeting the increasingly demanding requirements of integration and miniaturization. Our work endows ferromagnetic heterostructures with controllable spatial characteristics and benefits their applications in wireless communications and holographic imaging.

Ultraefficient Terahertz Emission Mediated by Shift-Current Photovoltaic Effect in Layered Gallium Telluride.

Generating terahertz waves using thin-layered materials holds great potential for the realization of integrated terahertz devices. However, previous studies have been limited by restricted radiation intensity and finite efficiency. Exploiting materials with higher efficiency for terahertz emission has attracted increasing interest worldwide. Herein, with visible-light excitation, a thin-layered GaTe film is demonstrated to be a promising emitter of terahertz radiation induced by the shift-current photovoltaic effect. Through theoretical calculations, a transient charge-transfer process resulting from the asymmetric structure of GaTe is shown to be the origin of an ultrafast shift current. Furthermore, it was found that the amplitude of the resulting terahertz signals can be manipulated by both the fluence of the pump laser and the orientation of the sample. Such high emission efficiency from the shift current indicates that the layered material (GaTe) is an excellent candidate for photovoltaics and terahertz emitters.

Evaluation of remediation of Cr(VI)-contaminated soils by calcium polysulfide: Long-term stabilization and mechanism studies.

In the remediation of Cr(VI)-contaminated soils, the effectiveness and long-term stability are critical qualities for the selection of a reductant. In current engineering practices, iron-based materials and sulfides are the most prevalent reductants, and calcium polysulfide (CaS4) is considered as the one with the highest effectiveness and strongest long-term stabilization ability. But this opinion is questioned by the high interference ability of CaS4 to soil Cr(VI) analysis. This study provides a pretreatment method to eliminate the interference of residual ferrous and sulfides to soil Cr(VI) analysis. By this pretreatment method and comparing with FeSO4 and Na2S, the mechanisms of the false high effectiveness and strong long-term stabilization ability of CaS4 is revealed. In the remediation process, CaS4 produces much elemental sulfur (S0) which remains in the soils. During the alkaline digestion, the S0 generates polysulfide which reduces the extracted Cr(VI), inducing serious negative analysis bias. When this negative bias is eliminated by pretreatment method, analysis results show that CaS4 exhibits lowest effectiveness. The S0 cannot be leached away from soils and oxidized by oxygen under natural conditions, this makes CaS4 exhibit a persistent interference ability, which is mistaken for a strong long-term stabilization ability.

Interference of sulfide with iron ions to the analysis of Cr(â ¥) by Method 3060a & Method 7196a.

When Cr(Ⅵ)-contaminated soil was remediated with sulfide, due to incomplete reaction and overdose, excess sulfide could remain in the soil inducing unacceptable underestimation of residual Cr(Ⅵ) analysis, which would get worse when iron ions were introduced in. Unfortunately, the quality control policy of Method 3060a cannot distinguish the difference between real zero and false zero residual Cr(Ⅵ) when their spike recoveries are zero. This paper systematically investigated the sulfide-induced Cr(Ⅵ) reduction in Cr(Ⅵ) analysis by Method 3060a & Method 7196a. Experimental results indicate that the sulfide-Cr(Ⅵ) reaction mainly occurs during alkaline digestion and pH adjustment processes, and iron ions as an electron transfer carrier between sulfide and Cr(Ⅵ) can catalyze the redox reaction during alkaline digestion. Besides, the high temperature in alkaline digestion significantly accelerates the redox reaction which usually is negligible at room temperature. Sulfur of high concentrations in remediated soils can also cause unacceptable underestimation of Cr(Ⅵ) due to the production of sulfide ions by disproportionation reaction in alkaline digestion. This paper also provides a method to eliminate sulfide ions from alkaline digestion solution before pH adjustment and suggests some possible solutions to the ferrous or sulfide-induced Cr(Ⅵ) analysis bias.

System-Level Model and Simulation of a Frequency-Tunable Vibration Energy Harvester.

In this paper, we present a macroscale multiresonant vibration-based energy harvester. The device features frequency tunability through magnetostatic actuation on the resonator. The magnetic tuning scheme uses external magnets on linear stages. The system-level model demonstrates autonomous adaptation of resonance frequency to the dominant ambient frequencies. The harvester is designed such that its two fundamental modes appear in the range of (50,100) Hz which is a typical frequency range for vibrations found in industrial applications. The dual- frequency characteristics of the proposed design together with the frequency agility result in an increased operative harvesting frequency range. In order to allow a time-efficient simulation of the model, a reduced order model has been derived from a finite element model. A tuning control algorithm based on maximum-voltage tracking has been implemented in the model. The device was characterized experimentally to deliver a power output of 500 µW at an excitation level of 0.5 g at the respected frequencies of 63.3 and 76.4 Hz. In a design optimization effort, an improved geometry has been derived. It yields more close resonance frequencies and optimized performance.

An interpretation to Cr(â ¥) leaching concentration rebound phenomenon with time in ferrous-reduced Cr(â ¥)-bearing solid matrices.

Toxicity characteristic leaching procedure (TCLP) is a prevalent way to evaluate the treatment effectiveness for Cr(Ⅵ)-bearing solid matrices (CBSM). But when a certain amount of residual reductants are present in the treated CBSM, Cr(Ⅵ) leaching concentration rebound phenomenon (CLCRP) occurs, which invalidates the TCLP. This study explores the microstructure of ferrous-reduced CBSM and proves that the residual Cr(Ⅵ), FexCr1-x(OH)3 precipitate and residual ferrous are separately distributed in a three-layer structure. In natural scenarios, the residual ferrous in the out-layer is firstly flushed away by rainfall and groundwater or oxidized by dissolved oxygen, resulting in the decrease of ferrous with time. Residual Cr(Ⅵ), due to being blocked by precipitate layer, is less flushed away. While in TCLP, all of released residual ferrous and Cr(Ⅵ) are in the leachate and react till one of them is almost exhausted, resulting in the underestimation of Cr(Ⅵ) leaching concentrations. The longer the samples experience the natural scenarios, the less of the residual ferrous, resulting in the decline of underestimation of Cr(Ⅵ) leaching concentrations with time. This study also provides a pretreatment which can effectively reduce the residual ferrous, achieving more accurate Cr(Ⅵ) leaching concentrations and eliminating CLCRP.

Caudatin targets TNFAIP1/NF-κB and cytochrome c/caspase signaling to suppress tumor progression in human uterine cancer.

Caudatin, a C-21 steroidal glyco-side isolated from Chinese herbs, has a long history of use for the treatment of multiple diseases, including cancers. However, the precise mechanisms of actions of caudatin in human uterine cancer cells remain unclear. In this study, we investigated the molecular mechanisms by which caudatin inhibits cell growth in human cervical carcinoma cell line (HeLa) and endometrial carcinoma cell line (HEC-1A). Treatment with caudatin promoted cell morphology change, inhibited cell proliferation, colony formation, migration and spheroid formation, and induced cell apoptosis. Our results showed that the expression of tumor necrosis factor; α-induced protein 1 (TNFAIP1) was downregulated in uterine cancer cells and tissues compared to paired adjacent non-tumor uterine tissues. Further molecular mechanism study showed that caudatin can directly regulate TNFAIP1 expression in a concentration-dependent manner and also associated with the downregulation of NF-κB and upregulation of BAX/BcL-2 ratio and caspase-3. Moreover, we found that overexpression of TNFAIP1 inhibits the growth and invasion, and induces apoptosis in uterine cancer cells through inhibition of the NF-κB pathway, suggesting that TNFAIP1 may act as a potential therapeutic target for the treatment of cancer. We found that caudatin inhibited tumorigenicity and upregulated TNFAIP1 in vivo. Taken together, caudatin impacts on cell proliferation, migration and apoptosis of uterine cancer cells by regulating several carcinogenesis-related processes, including a novel mechanism involving the targeting of TNFAIP1/NF-κB signaling. Our findings provide new insights into understanding the anticancer mechanisms of caudatin in human uterine cancer therapy.

Conceptual design and experiments of electrochemistry-flushing technology for the remediation of historically Cr(â ¥)-contaminated soil.

A conceptual design and experiments, electrochemistry-flushing (E-flushing), using electrochemistry to enhance flushing efficiency for the remediation of Cr(Ⅵ)-contaminated soil is presented. The rector contained three compartments vertically superposed. The upper was airtight cathode compartment containing an iron-cathode. The middle was soil layer. The bottom was anode compartment containing an iron-anode and connected to a container by circulation pumps. H2 and OH(-) ions were produced at cathode. H2 increased the gas pressure in cathode compartment and drove flushing solution into soil layer forming flushing process. OH(-) ions entered into soil layer by eletromigration and hydraulic flow to enhance the desorption of Cr(Ⅵ). High potential gradient was applied to accelerate the electromigration of desorbed Cr(Ⅵ) ions and produced joule heat to increase soil temperature to enhance Cr(Ⅵ) desorption. In anode compartment, Fe(2+) ions produced at iron-anode reduced the desorbed Cr(Ⅵ) into Cr(3+) ions, which reacted with OH(-) ions forming Cr(OH)3. Experimental results show that Cr(Ⅵ) removal efficiency of E-flushing experiments was more than double of flushing experiments and reached the maximum of removal efficiency determined by desorption kinetics. All electrochemistry processes were positively used in E-flushing technology.