Smart Enzyme-Like Polyphenol-Copper Spray for Enhanced Bacteria-Infected Diabetic Wound Healing.

Developing functional medical materials is urgent to treat diabetic wounds with a high risk of bacterial infections, high glucose levels and oxidative stress. Here, a smart copper-based nanocomposite acidic spray has been specifically designed to address this challenge. This copper-based nanocomposite is pH-responsive and has multienzyme-like properties. It enables the spray to effectively eliminate bacteria and alleviate tissue oxidative pressure, thereby accelerating the healing of infected diabetic wounds. The spray works by generating hydroxyl radicals through catalysing H2O2, which has a high sterilization efficiency of 97.1%. As alkaline micro-vessel leakage neutralizes the acidic spray, this copper-based nanocomposite modifies its enzyme-like activity to eliminate radicals. This reduces the level of reactive oxygen species in diabetic wounds by 45.3%, leading to a similar wound-healing effect between M1 diabetic mice and non-diabetic ones by day 8. This smart nanocomposite spray provides a responsive and regulated microenvironment for treating infected diabetic wounds. It also offers a convenient and novel approach to address the challenges associated with diabetic wound healing.

Uranium in Chinese coals: Concentration, spatial distribution, and modes of occurrence.

Uranium in coals is an environmental radionuclide with resource utilization value. To comprehensively understand the prevalence of uranium in Chinese coals, the concentration, spatial distribution, and modes of occurrence were analyzed based on the data acquired from 1326 coal samples. Chinese coals are relatively rich in uranium, with the arithmetic and weighted average concentrations of 3.08 and 2.38 mg/kg, respectively. The regions with high uranium enrichment in coals are Guizhou, Guangxi, Yunnan, Sichuan and Chongqing, which are mainly located in southwestern China. The uranium was more enriched in Late Permian coal and medium-to-high metamorphic coal. Organic matter is the main carrier of uranium in coals, followed by silicates and sulfides. The factors affecting uranium enrichment in coal at the national scale include magma intrusions, volcanic ash, seawater influence, low-temperature hydrothermal fluids, and paleoclimate. This paper provides a reference for further research on environmental management and resource utilization of uranium in Chinese coals.

Asymmetric barrier membranes based on polysaccharide micro-nanocomposite hydrogel: Synthesis, characterization, and their antibacterial and osteogenic activities.

Guided tissue regeneration (GTR) strategies enable periodontal tissue regeneration, generally by providing barrier membranes. However, currently available membranes have limited osteoconductive and antibacterial potential. To address these challenges, we fabricated a new asymmetric barrier membrane. Agarose hydrogel functions as the main body of the barrier membrane. Hollow carbonated hydroxyapatite (CHA) prepared by hydrothermal method, was sedimented in agarose to exhibit an asymmetrical structure. And ε-poly-lysine (ε-PLL) was chosen as an antimicrobial agent to equip the membrane with long-lasting antibacterial activity. With the increased dose of CHA addition, the barrier membrane shows better biocompatibility, and higher mechanical properties. We demonstrated the osteoconductivity and antibacterial properties of the membrane in vitro and in vivo. In summary, our findings suggest that the barrier membrane has good osteoconductive and antibacterial properties, indicating its potential for periodontal tissue engineering.

Spatial distribution of harmful trace elements in Chinese coalfields: An application of WebGIS technology.

Harmful trace elements in coal have caused serious damage to the environment and human health. Understanding their spatial distribution is helpful for environmental health assessment and for their effective control and utilization. To further explore the geospatial distribution of harmful trace elements found in Chinese coals, this work constructed the Trace Elements in Chinese Coals Database Management System (TECC), and analysed the spatial distribution of harmful trace elements by applying spatial data algorithms and visual technology of WebGIS. The main results are as follows: (1) The mean concentrations of 25 harmful trace elements (Ag, As, B, Ba, Be, Cd, Cl, Co, Cr, Cu, F, Hg, Mn, Mo, Ni, P, Pb, Sb, Se, Sn, Th, Tl, U, V, Zn) in Chinese coals are provided, using the "reserve-concentration" weighted calculation method; (2) Using As, Hg, F, and U as examples, the spatial distribution of harmful trace elements in Chinese coalfields is visually displayed; (3) Harmful trace elements are extremely unevenly distributed in Chinese coalfields; they are mainly concentrated in south China, especially in the southwest region, and some elements may also be concentrated in coals from northwest, northeast, and north China. The enrichment of harmful trace elements in Chinese coals is the result of a combination of multiple factors, such as the nature of the region the coal is sourced from, sedimentary facies, coal-forming plants, and magmatic hydrothermal processes. This work can serve as a reference for the study of harmful trace elements in coal, including assessment of their environmental and health impacts.