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Chem Commun (Camb)
; 57(39): 4839-4842, 2021 May 14.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33870368
RESUMEN
A novel universal N-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides from N-terminal dipeptides (32 examples, up to 91%).