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Trends Mol Med ; 11(6): 293-8, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15949771

RESUMEN

Recent advances in the efficiency of transgenic technology have important implications for medicine. The production of therapeutic proteins from animal bioreactors is well established and the first products are close to market. The genetic modification of pigs to improve their suitability as organ donors for xenotransplantation has been initiated, but many challenges remain. The use of transgenesis, in combination with the method of RNA interference to knock down gene expression, has been proposed as a method for making animals resistant to viral diseases, which could reduce the likelihood of transmission to humans. Here, the latest developments in transgenic technology and their applications relevant to medicine and human health will be discussed.


Asunto(s)
Transgenes , Animales , Reactores Biológicos , Biotecnología , Núcleo Celular/metabolismo , Citoplasma/metabolismo , Modelos Animales de Enfermedad , Ingeniería Genética , Humanos , Interferencia de ARN , ARN Mensajero/metabolismo , Trasplante , Trasplante Heterólogo
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