Asunto(s)
COVID-19/virología , Enfermedades Transmisibles Importadas/virología , SARS-CoV-2/genética , Adulto , COVID-19/diagnóstico , Enfermedades Transmisibles Importadas/diagnóstico , Femenino , Genoma Viral/genética , Humanos , Masculino , Mutación , Filogenia , SARS-CoV-2/clasificación , SARS-CoV-2/aislamiento & purificación , Vietnam/epidemiologíaRESUMEN
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.