[The effect of the components of general anesthesia on the level of carcinoembryonic antigen in the blood serum of patients with cancer of the large intestine]. / Vliianie komponentov obshchei anestezii na uroven rakovo-émbrionalnogo antigena v syvorotke krovi bolnykh rakom tolstoi kishki.

The effect of calipsol and thiopental (the most frequent drugs used for basis anesthesia), as well as their combinations with narcotic analgesics fentanyl, morphine, promedole and a neuroleptic droperidol on the level of carcinoembryonic antigen (CEA) in patients with colonic cancer has been studied. A significant effect of anesthetics on CEA level in the postoperative period has been established. The lowest CEA level was observed when calipsol, morphine, and promedole were used as components of narcotic analgesics.

[Tumor markers--a diagnostic and prognostic test]. / Opukholevye markery--diagnosticheskii i prognosticheskii test.

Blood levels of carcinoembryonic antigen (CEA), alpha-fetoprotein, ferritin, ACTH. triiodothyronine and thyroxin were measured by radioimmunoassay in 217 cases of lung, hepatopancreatoduodenal and colonic cancer, 61 patients with nontumor pathology of those sites and in 37 healthy controls. CEA proved the most reliable marker of lung and colonic cancer and tumor-related mechanical jaundice, its lowest concentration in 65-100% of cancer patients exceeding the highest levels observed in controls. In the colorectal group, CEA level returned to normal after radical surgery and rose again at recurrence or distant metastases. Ferritin, cortisol and ACTH appeared less efficient.

[Determination of carcinoembryonic antigen content as a diagnostic and prognostic test in colorectal cancer]. / Opredelenie soderzhaniia rakovoémbrional'nogo antigena kak diagnosticheskii i prognosticheskii test pri kolorektal'nom rake.

Of the 120 patients with colorectal cancer, 24 had distant metastases of a tumor. In these patients, increase in the level of carcinoembryonic antigen (CEA) and ferritin in the peripheral blood serum was noted as compared with those in patients without tumor metastases (P less than 0.001). Measuring of CEA content in the peripheral and regional blood can be used in preoperative diagnosis of metastases of colorectal cancer.

[The natural killer blood count in patients with breast, colon and rectal cancers]. / Kolichestvo estestvennykh killerov v krovi u bol'nykh rakom molochnoi zhelezy, obodochnoi i priamoi kishok.

Blood level of large granular cells was assayed in patients suffering cancer of the breast (30), colon (13) and rectum (34) at various stages of the disease. This level in cancer patients was half as much that in healthy controls. Procedures employed for treatment of the above pathologies were shown to contribute to inhibition of peripheral blood spontaneous cytotoxicity. This makes the case for immunocorrection. The cytologic method of identification of large granular lymphocytes may be used to monitor cell-mediated antitumor immunity in breast and colorectal cancer patients in the course and after treatment and, therefore, serve the diagnosis of recurrence and metastasis.