Effects of a multicomponent physical exercise programme on perceived health-related quality of life and on depressive symptoms in older adults living in long-term nursing homes.

Objectives: This study aimed to investigate the impact of a multicomponent exercise programme on perceived health-related quality of life (HRQoL) and depressive symptomatology in older people living in a long-term nursing home (LTNH). Methods: A quasi-experimental study was conducted. Forty-one older people were conveniently selected from the largest LTNH in the Basque Country. The participants were assigned to either an intervention group (n = 21) or a control group (n = 20). The intervention group participated in 50-min moderate intensity multicomponent physical exercise sessions (strength and balance, three sessions a week for 3 months). The control group participants continued their usual activities in the LTNH. Assessments were completed at baseline and reassessed after the 12-week intervention by the same nurse researchers who filled out the questionnaires: the 36-item Short Form Survey (SF-36) and the Geriatric Depression Scale (GDS). Results: Thirty-eight participants completed the study (19 participants in each group). In the SF-36 parameters, physical functioning increase in the intervention group tends with a mean increase of 11.06 units (a 17.2% increase over the pre). In the role-emotional, the increase in the intervention group is with a mean increase of 5.27 units (a 29.1% increase over the pre) (P < 0.05). In social functioning, the increase in the control group is significant with a mean increase of 13.16 units (a 15.4% increase over the pre) (P < 0.05). There are no significant changes in the rest of the parameters, there are no differences between groups in the evolutionary pattern either. Conclusions: As for the effects of the multicomponent exercise programme on HRQoL and depressive symptomatology, no statistically significant effects were obtained in the outcome data among older adults living in LTNHs. An increase in the sample size could confirm the trends obtained. The results may help inform the design of future studies.

Reducing ageism combining ageing education with clinical practice: A prospective cohort study in health sciences students.

AIM: To analyse the impact of an intervention combining ageing education with clinical practice in nursing homes on a nursing cohort's negative stereotypes and prejudices towards ageing. DESIGN: A prospective cohort study was conducted in September 2019-October 2020 in a population of health sciences students (n = 222). METHODS: Questionnaire of Negative Stereotypes towards Aging (CENVE) and Aging Semantic Differential (DSE) were used to examine negative stereotypes and prejudices towards ageing in the nursing cohort exposed to the ageing education and practice intervention compared to a medical cohort that received no intervention. Group-by-time interaction, controlled by sex and age, for the effect of the intervention on CENVE and DSE scores was determined by mixed-design ANOVA. RESULTS: The nursing cohort significantly reduced negative stereotypes and prejudices towards ageing when compared to the medical cohort in total (F = 26.926; p < 0.001), health factor (F = 16.812; p < 0.001), motivational and social factor (F = 11.266; p = 0.001), and character and personality factor (F = 19.202; p < 0.001) scores of CENVE scale and in DSE (F = 7.826; p = 0.006).

Sex Differences in Frailty Factors and Their Capacity to Identify Frailty in Older Adults Living in Long-Term Nursing Homes.

Frailty is a phenomenon that precedes adverse health events in older people. However, there is currently no consensus for how to best measure frailty. Several studies report that women have a higher prevalence of frailty than men, but there is a gap in studies of the high rates of frailty in older people living in long-term nursing homes (LTNHs) stratified by sex. Therefore, we analyzed health parameters related to frailty and measured their capacity to identify frailty stratified by sex in older people living in LTNHs. According to the Fried Frailty Phenotype (FFP), anxiety increased the risk of frailty in women, while for men functionality protected against the risk of frailty. Regarding the Tilburg Frailty Indicator (TFI), functionality had a protective effect in men, while for women worse dynamic balance indicated a higher risk of frailty. The analyzed parameters had a similar capacity for detecting frailty measured by the TFI in both sexes, while the parameters differed in frailty measured by the FFP. Our study suggests that assessment of frailty in older adults should incorporate a broad definition of frailty that includes not only physical parameters but also psycho-affective aspects as measured by instruments such as the TFI.

Influence of the COVID-19 Pandemic on the Lifestyles of Health Sciences University Students in Spain: A Longitudinal Study.

The COVID-19 pandemic has significantly impacted daily activities worldwide. University students may have experienced substantial changes in daily living as a result of restrictions on university attendance. The return to normalcy may take a long time, and understanding the influence that shifts in daily routines have had on the lifestyles of university students may inform approaches to support overall well-being. We analyzed changes in the lifestyles of students enrolled at a health sciences university during the COVID-19 pandemic. This longitudinal study took place at the Faculty of Medicine and Nursing in the University of the Basque Country in Spain, and the final sample consisted of 113 nursing students, 109 medical students, and 45 physiotherapy students. Our results demonstrate changes in lifestyles of university students during the pandemic. MedDiet adherence scores and the percentage of students with high adherence increased during the pandemic. This increase was due to the increased consumption of vegetables and nuts. In terms of physical activity, the practice of moderate and intense physical activity was maintained. These results provide important information for both public health authorities and educational institutions to guide strategies to maintain the well-being of students and enhance opportunities for young adults to lead a healthy lifestyle.

Bone Health and Its Relationship with Impact Loading and the Continuity of Physical Activity throughout School Periods.

Bone is influenced by physical activity (PA) throughout life, but childhood and adolescence provide a key opportunity to maximize peak bone mass. Thus, it is important to identify the relationship between PA practiced in childhood and young adulthood to design a promotion plan for bone health. The purpose of this study was to analyze the relationship between different impact-loading PAs (and their continuity throughout school periods from childhood to young adulthood) and bone stiffness index (SI). In this cross-sectional study, which was conducted on 145 university students aged 18-21 years, bone measurements were measured by quantitative ultrasonometry (QUS), and PA information was recalled using a self-administered questionnaire. Associations between the SI and the impact of PA performed during secondary school (p = 0.027), high school (p = 0.002), and university (p = 0.016) periods were observed. The continuity of PA over a longer period of time was related to a higher SI (p = 0.007). Those who practiced PA throughout all school periods had a higher SI than those who practiced during primary school only (p = 0.038) or through primary and secondary schools (p = 0.009). These results suggest that impact-loading PA practiced during different school periods is related to higher values of the SI. Therefore, continuous PA from an early age may be an important contributing factor to achieving and maintaining adequate bone health.

Sub-Saharan African immigrant women's experiences of (lack of) access to appropriate healthcare in the public health system in the Basque Country, Spain.

BACKGROUND: Immigrant populations face diverse barriers to accessing appropriate healthcare services on several levels. In the Basque Country, Sub-Saharan African women were identified as facing the largest barriers to access them. The aim of the study is to analyse Sub-Saharan African immigrant women's perceptions and experiences of access to appropriate healthcare in the public health system in the Basque Country, Spain. METHODS: Fourteen women from eight Sub-Saharan African countries who have used the Basque public healthcare services were interviewed. A qualitative content analysis was applied: meaning that units were identified, coded and the resulting codes were then organized into three categories. RESULTS: The first category, Fearing to enter a health system perceived as not friendly for immigrants, included factors, mainly those related to legal conditions for accessing healthcare services and lack of lawful documentation, that made women avoid or discontinue seeking out healthcare. The second category, Being attended on professionals' own communication terms, comprised how the lack of effective communication compromised not only the access of the immigrant women to healthcare services, but also their health. Lastly, the third category, Is mistreatment based on racism or merely on bad luck? described how being an immigrant and black influenced the way they were (mis)treated in the health system. CONCLUSION: For Sub-Saharan African immigrant women, accessing appropriate healthcare in the Basque Country was perceived to be subject to institutional barriers. At the legal level, barriers included lack of entitlement, difficulties in fulfilling legal access conditions and lack of documentation. The lack of communication with health centre staff and their attitudes, guided by a stereotyped social image of immigrants and black people, also hindered their possibilities of receiving appropriate healthcare. Facilitators for accessing healthcare included strategies from individual professionals, personal networks and social actors to help them to cope with the barriers. There is a need of reinforcing inclusion values and rights-based approach to attention among staff at the health centres to have more non-discriminatory and culturally appropriate health systems.

Associations of Anthropometric Characteristics, Dietary Habits, and Aerobic Capacity With Cardiovascular Risk Factors of Health-Science Students.

The aim of this cross-sectional study was to study the relative importance of dietary habits and aerobic capacity in parameters related to cardiovascular risk in 271 female and 95 male health-science students (mean age = 19.1 ± 1.4 years). In females, fatty-meat consumption predicted triglycerides (ß = .649, p < .001) and high-density lipoprotein (HDL; ß = -.242, p = .001) and low-density lipoprotein (LDL; ß = .373, p < .001) cholesterol levels. Consumption of nuts, legumes, and complex carbohydrates predicted triglyceride (ß = -.099, p = .074), HDL (ß = .231, p = .001), and LDL (ß = -.155, p = .025) levels, respectively. Aerobic capacity (ß = -.245, p < .001) and fatty-meat intake (ß = .230, p < .001) predicted diastolic blood pressure (BP); body mass index (BMI) predicted systolic BP (ß = .340, p < .001). In males, body fat percentage was the strongest predictor of triglycerides (ß = .348, p = .004), cholesterol (ß = .366, p = .006), HDL (ß = -.378, p = .004), and LDL (ß = .271, p = .043) levels. Aerobic capacity (ß = -.263, p = .013) and fatty-meat consumption (ß = .334, p = .005) independently predicted triglyceride levels. Nut (ß = -.286, p = .013) and fatty-meat intake (ß = .361, p = .002) predicted systolic BP, while BMI predicted diastolic BP (ß = .209, p = .045). As health sciences students, these participants are future health professionals; targeting such populations is important for chronic disease prevention.

Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma.

OBJECTIVE: To analyze the mRNA and protein expression of cannabinoid receptors CB1 and CB2 in chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma (RO). DESIGN AND METHODS: Fresh and formalin-fixed tissue samples of ChRCC and RO were analyzed by using real-time quantitative RT-PCR and immunohistochemical techniques (n=40). RESULTS: Quantitative RT-PCR analysis showed that CB1 mRNA was underexpressed by 12-fold in ChRCC and had a variable expression in RO. CB1 protein showed intense positive immunostaining in both neoplasms. Both CB2 mRNA and protein were not expressed in tumor and non tumor renal tissue. CONCLUSION: This distinct immunoprofile may eventually be used as an additional tool with practical interest in the differential diagnosis of renal tumors.

Anthropometric, physiological and maturational characteristics in selected elite and non-elite male adolescent basketball players.

We investigated the anthropometric, physiological and maturation characteristics of young players (13-14 years old) associated with being successful in basketball. Body parameters were measured (stature, total body mass, skinfolds and lengths) and physiological capacities were assessed by endurance, sprint (20 m), jump and dribbling tests. Chronological age (CA) was recorded and maturity estimated using predicted age at peak height velocity (APHV). Anthropometric analysis indicated that elite players were taller, heavier and had a higher percentage of muscle. Further, physiological testing showed that these elite players perform better in jump, endurance, speed and agility tests (especially in the agility and ball tests). In addition, these skills are correlated with point average during the regular season. More basketball players born in the first semester of the year are selected and there is a predominance of early-maturing boys among those selected for the elite team. Those who are more mature have advantages in anthropometric characteristics and physiological test results. In conclusion, around puberty, physical and physiological parameters associated with maturity and CA are important in determining the success of basketball players. These findings should be taken into account by trainers and coaches, to avoid artificial bias in their selection choices.

Altered peptidase activities in thyroid neoplasia and hyperplasia.

BACKGROUND: Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an additional tool in the diagnosis/prognosis of these diseases. However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland. METHODS: The catalytic activity of 10 peptidases in a series of 30 PTC, 10 FTA, and 14 TNH was measured fluorimetrically in tumour and nontumour adjacent tissues. RESULTS: The activity of DPPIV/CD26 was markedly higher in PTC than in FTA, TNH, and nontumour tissues. Aspartyl aminopeptidase (AspAP), alanyl aminopeptidase (AlaAP), prolyl endopeptidase, pyroglutamyl peptidase I, and aminopeptidase B activities were significantly increased in thyroid neoplasms when compared to nontumour tissues. AspAP and AlaAP activities were also significantly higher in PTC than in FTA and TNH. CONCLUSIONS: These data suggest the involvement of DPPIV/CD26 and some cytosolic peptidases in the neoplastic development of PTC and FTA. Further studies will help to define the possible clinical usefulness of AlaAP and AspAP in the diagnosis/prognosis of thyroid neoplasms.

Physiological and anthropometric characteristics of young soccer players according to their playing position: relevance for the selection process.

The aim of this study was to establish the anthropometric and physiological profiles of young nonelite soccer players according to their playing position, and to determine their relevance for the selection process. Two hundred forty-one male soccer players who were members of the Getxo Arenas Club (Bizkaia) participated in this study. Players, age 17.31 (+/- 2.64) years, range 14-21 years, were classified into the following groups: forwards (n = 56), midfielders (n = 79), defenders (n = 77), and goalkeepers (n = 29). Anthropometric variables of participants (height, weight, body mass index, 6 skinfolds, 4 diameters, and 3 perimeters) were measured. Also, their somatotype and body composition (weights and percentages of fat, bone, and muscle) were calculated. Participants performed the Astrand test to estimate their absolute and relative VO2max, an endurance test, sprint tests (30 meters flat and 30 meters with 10 cones) and 3 jump tests (squat jump, counter movement jump and drop jump). Forwards were the leanest, presenting the highest percentage of muscle. They were the best performers in all the physiological tests, including endurance, velocity, agility, and power. In contrast, goalkeepers were found to be the tallest and the heaviest players. They also had the largest fat skinfolds and the highest fat percentage, but their aerobic capacity was the lowest. In the selection process, agility and the jump tests were the most discriminating for forwards. In contrast, agility, height, and endurance were the key factors for midfielders. The defenders group was characterized by a lower quantity of fat. Thus, we may conclude that anthropometric and physiological differences exist among soccer players who play in different positions. These differences fit with their different workload in a game. Therefore, training programs should include specific sessions for each positional role.

Exercise, physical fitness, and dietary habits of first-year female nursing students.

The objective of the present study was to evaluate the practice of regular physical exercise, the anthropometrical and physiological characteristics, and the dietary habits of a group of female nursing students (n=46) and of a control group of female students from other disciplines (n=58) attending the University of the Basque Country. To this end, diets and leisure-time physical exercise were analyzed and the following variables were measured: body mass index, body composition, blood pressure, maximal oxygen consumption (VO2 max), and explosive muscle strength. Results show that the percentage of sedentary students was higher among first-year nursing students (50%) than among other matched students (43.6%). Regular physical exercise in nursing students was found to be positively correlated with higher absolute (p < .01) and relative VO2 max (p < 0.05) and with lower diastolic blood pressure (p < 0.05). Analysis of the diets of the nursing students showed that their energetic intake was deficient and was very low in carbohydrates and very high in fat and protein. Statistically significant differences between the two groups in anthropometric indices were not observed. The competence to provide adequate nutritional and preventive physical exercise recommendations was higher among active final-year nursing students than among sedentary final-year nursing students. Overall, the results of the present study highlight the need for a greater emphasis on the benefits of regular physical exercise and an adequate nutritional education early in the nursing educational program to encourage students to adopt healthier behaviors and to provide more effective preventive physical exercise and nutritional counseling for their future patients.

Nutritional intake in soccer players of different ages.

The purpose of this study was to evaluate the dietary practices of soccer players of different ages. The diets of the members of four soccer teams (mean ages of 14.0, 15.0, 16.6 and 20.9 years, respectively) were examined. Our results show that the caloric intake per kilogram of body mass was significantly higher among the youngest players when compared with the adult players (P < 0.05). The contribution of carbohydrates to total energy intake was lower than that recommended for athletes. This contribution decreased with age from 47.4% of total energy intake for the 14-year-olds to 44.6% for the adult players. No significant differences in protein or total fat intake were detected among the teams examined. Overall, our results show that the nutritional intake of the soccer players was not optimal, and that this intake was poorer among the adult players than among the adolescents. On the basis of our results, we recommended that nutritional education should be given to soccer players at an early age and should continue throughout adolescence, not only with a view to improving performance but also to promoting more healthy dietary practices in the long term.

Ontogeny of soluble and particulate prolyl endopeptidase activity in several areas of the rat brain and in the pituitary gland.

We have analyzed the activity of prolyl endopeptidase (PEP) in several areas of the rat brain (brain cortex, striatum, brain stem, cerebellum and hypothalamus) and in the pituitary gland during ontogeny. In all of these areas, we observed a reduction in PEP activity during development. However, the temporal profile of these alterations was found to be area specific and differences in the ontogeny of the soluble and particulate forms of PEP were observed. Thus, by postnatal day 20 (PD20), soluble PEP activity had began to decrease in the brain cortex and striatum, whereas decreased soluble PEP activity was observed earlier, at PD15, in the brain stem and cerebellum. Changes in the particulate fraction were even more pronounced. Senescence was associated with decreased soluble PEP activity in the striatum, but in contrast, particulate PEP activity was found to be increased in the senescent brain stem. The present results indicate that alterations in the levels of activity of PEP may represent an important event in the development and aging of the central nervous system.