RESUMEN
BACKGROUND: A low calcium intake is a well-known factor that influences the bone mineral density (BMD) maintenance. In the presence of inadequate calcium intake, secondary hyperparathyroidism develops, leading to an increased bone turnover and fracture risk. AIMS: To assess the dietary calcium intake in relation with osteoporosis and fragility fracture in a cohort of Italian individuals evaluated for low BMD. METHODS: A 7-day food-frequency questionnaire was administered to 1793 individuals, who were consecutively referred at the Centers of the Italian Society for Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS) for low BMD. RESULTS: In 30.3% and 20.9% of subjects, the calcium intake was inadequate (< 700 mg/day) and adequate (> 1200 mg/day), respectively. As compared with patients with adequate calcium intake, those with inadequate calcium intake were younger (65.5 ± 10.8 vs 63.9 ± 11.5 years, p = 0.03) and they more frequently reported adverse reactions to food (3.2% vs 7.2% p = 0.01) and previous major fragility fractures (20.8% vs 27.0%, p = 0.03). Patients with calcium intake < 700 mg/day showed a higher prevalence of diabetes mellitus, idiopathic hypercalciuria and food allergy/intolerance (8.1%, 5.1%, 7.2%, respectively) than patients with calcium intake > 700 mg/day (5.3%, 3.0%, 4.1%, respectively, p < 0.04 for all comparisons), also after adjusting for age, gender and body mass index. In 30.3% of fractured subjects, the calcium intake was < 700 mg/day. DISCUSSION: In Italy, a low calcium intake is highly prevalent in individuals at risk for low BMD. Importantly, an inadequate calcium intake is highly prevalent even in patients with history of fragility fractures. CONCLUSIONS: Only about a fifth of patients being assessed for low BMD in an Italian SIOMMMS referral Centre have an adequate calcium intake.
Asunto(s)
Enfermedades Óseas Metabólicas , Calcio de la Dieta/administración & dosificación , Fracturas Óseas , Osteoporosis , Densidad Ósea , Fracturas Óseas/epidemiología , Humanos , Italia , Osteoporosis/epidemiologíaRESUMEN
INTRODUCTION: At this time, good quality randomized clinical trials assessing the effects of vitamin D supplementation on cardiometabolic outcomes are lacking in the international literature. AIM: To fill this gap, the Working Group on Vitamin D and Cardiorenal Disorders established jointly by the Italian Society of Hypertension (SIIA) and the Forum in Bone and Mineral Research conceived the HYPODD study (HYPOvitaminosis D and organ Damage). METHODS: HYPODD is a no-profit multicenter 12-month parallel-group double-blind placebo controlled randomized trial aiming to assess the effects of cholecalciferol supplementation on blood pressure control, antihypertensive drugs consumption and progression of target organ damage in patients with essential hypertension and 25-hydroxyvitamin D serum level lower than 20 ng/ml (vitamin D deficiency). HYPODD is coordinated by the European Society Excellence Center of Hypertension of Federico II University, Naples, and involves 12 academic institutions in Italy (Ancona, Milan, Padua, Perugia, Rome, Siena, Trieste, Turin, Udine, Varese, and Verona). RESULTS AND CONCLUSION: The HYPODD study has been registered at the Agenzia Italiana del Farmaco-Osservatorio sulla Sperimentazione Clinica del Farmaco (AIFA-OsSC) and EUDRACT sites (n° 2012-003514-14) and has been approved by the Ethical Committees of all the Centers involved in the study. The patients' recruitment is currently underway.
Asunto(s)
Antihipertensivos/uso terapéutico , Presión Arterial/efectos de los fármacos , Colecalciferol/uso terapéutico , Suplementos Dietéticos , Hipertensión/tratamiento farmacológico , Deficiencia de Vitamina D/tratamiento farmacológico , Biomarcadores/sangre , Protocolos Clínicos , Progresión de la Enfermedad , Método Doble Ciego , Humanos , Hipertensión/complicaciones , Hipertensión/diagnóstico , Hipertensión/fisiopatología , Italia , Selección de Paciente , Tamaño de la Muestra , Factores de Tiempo , Resultado del Tratamiento , Vitamina D/análogos & derivados , Vitamina D/sangre , Deficiencia de Vitamina D/sangre , Deficiencia de Vitamina D/complicaciones , Deficiencia de Vitamina D/diagnósticoRESUMEN
Atypical or silent celiac disease may go undiagnosed for many years and can frequently lead to loss of bone mineral density, with evolution to osteopenia or osteoporosis. The prevalence of the latter conditions, in case of new diagnosis of celiac disease, has been evaluated in many studies but, due to the variability of epidemiologic data and patient features, the results are contradictory. The aim of this study was to evaluate bone mineral density by dual-energy X-ray absorptiometry in 175 consecutive celiac patients at time of diagnosis (169 per-protocol, 23 males, 146 females; average age 38.9 years). Dual-energy X-ray absorptiometry was repeated after 1 year of gluten-free diet in those with T-score value <-1 at diagnosis. Stratification of patients according to sex and age showed a higher prevalence of low bone mineral density in men older than 30 years and in women of all ages. A 1-year gluten-free diet led to a significant improvement in lumbar spine and femoral neck mean T-score value. We propose that dual-energy X-ray absorptiometry should be performed at diagnosis of celiac disease in all women and in male aged >30 years, taking into account each risk factor in single patients.
Asunto(s)
Densidad Ósea , Enfermedades Óseas Metabólicas/prevención & control , Enfermedad Celíaca/dietoterapia , Dieta Sin Gluten , Osteoporosis/prevención & control , Absorciometría de Fotón , Adulto , Enfermedades Óseas Metabólicas/diagnóstico por imagen , Enfermedades Óseas Metabólicas/etiología , Enfermedades Óseas Metabólicas/patología , Enfermedad Celíaca/complicaciones , Enfermedad Celíaca/diagnóstico por imagen , Enfermedad Celíaca/patología , Femenino , Cuello Femoral/diagnóstico por imagen , Cuello Femoral/patología , Humanos , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/patología , Masculino , Persona de Mediana Edad , Osteoporosis/diagnóstico por imagen , Osteoporosis/etiología , Osteoporosis/patología , Factores de RiesgoRESUMEN
In this article we describe the use of dual-energy X-ray absorptiometry (DXA) technique in the study of fetal and infant bone development. In particular, we review the results of densitometric studies on human developing dry bones such as spine, femur, and mandible; these data are compared with the results obtained with other methods used in the past. In particular DXA technique applied in dry is able to detect the first appearances of the ossification centers; show individual variability of bone mineral density yet during the prenatal life; and determine the correlation between bone mineral density and the variation of mechanical loading.
Asunto(s)
Densidad Ósea , Desarrollo Óseo , Feto/fisiología , Absorciometría de Fotón , Fémur/fisiología , Humanos , Mandíbula/fisiología , Osteogénesis , Columna Vertebral/fisiologíaRESUMEN
The purpose of this study was to evaluate the variability of bone density among three zones of adult human dry mandible and its relationship to age, gender, and dental status. Thirty-one dried mandibles (16 female ranging between 23 and 82 yr and 15 male ranging between 34 and 85 yr; 6 samples completely edentulous and 6 edentulous only in the molar-premolar zone) were analyzed by a Hologic QDR 1000 X-ray densitometer according to three zones: the ramus, the molar-premolar zone, and the incisor-canine zone. We found a significant inverse correlation between bone density of the ramus and age (r = 0.41, p = 0.02). The bone density of the incisor-canine zone was higher than the density of the other zones; males had a higher bone density than females in all zones analyzed. Our data suggest that mandibular bone density is influenced by age and gender in different ways according to the specific mandibular portion considered, whereas the dental status does not seem to influence mandibular bone density.