RESUMEN
Influenza viruses are constantly evolving and are therefore monitored worldwide in the hope to reduce the burden of disease by annual updates to vaccine recommendations. We conducted genomic sequencing of 110 influenza A and 30 influenza B viruses from specimens collected between October 2023 and February 2024 in Arizona, USA. We identified mutations in the hemagglutinin (HA) antigenic sites as well as the neuraminidase (NA) gene in our samples. We also found no unique HA and NA mutations in vaccinated yet influenza-infected individuals. Real-time genomic sequencing surveillance is important to ensure influenza vaccine effectiveness.
Asunto(s)
Genoma Viral , Virus de la Influenza A , Virus de la Influenza B , Gripe Humana , Mutación , Neuraminidasa , Arizona/epidemiología , Humanos , Gripe Humana/epidemiología , Gripe Humana/virología , Neuraminidasa/genética , Virus de la Influenza B/genética , Virus de la Influenza A/genética , Virus de la Influenza A/clasificación , Glicoproteínas Hemaglutininas del Virus de la Influenza/genética , Genómica/métodos , Filogenia , Adulto , Monitoreo Epidemiológico , Niño , Adolescente , Persona de Mediana Edad , Masculino , Femenino , Preescolar , Anciano , Vacunas contra la Influenza/inmunología , Vacunas contra la Influenza/genética , Adulto Joven , Secuenciación Completa del GenomaRESUMEN
We investigated a university-affiliated cohort of SARS-CoV-2 Omicron BA.2 infections in Arizona, USA. Of 44 cases, 43 were among students; 26 persons were symptomatic, 8 sought medical care, but none were hospitalized. Most (55%) persons had completed a primary vaccine series; 8 received booster vaccines. BA.2 infection was mild in this young cohort.
