RESUMEN
We report the case of a 11-year-old girl who developed an isolated hand-writing disorder with dysgraphia at the beginning of the school year in the sixth grade. A brain magnetic resonance angiography showed a round arteriovenous malformation sited in the left side of the midbrain extending to the ipsilateral medio-basal thalamus. Child neurologists should never neglect a thorough neurological evaluation in case of isolated worsening of handwriting, to rule out possible underlying organic causes.
Asunto(s)
Agrafia/patología , Malformaciones Arteriovenosas/patología , Tronco Encefálico/irrigación sanguínea , Escritura Manual , Agrafia/diagnóstico , Malformaciones Arteriovenosas/diagnóstico , Tronco Encefálico/anomalías , Tronco Encefálico/patología , Angiografía Cerebral , Niño , Diagnóstico Diferencial , Femenino , Humanos , Angiografía por Resonancia Magnética , Imagen por Resonancia Magnética , Mesencéfalo/anomalías , Mesencéfalo/irrigación sanguínea , Mesencéfalo/patología , Tálamo/anomalías , Tálamo/irrigación sanguínea , Tálamo/patologíaRESUMEN
PURPOSE: The present study aimed to assess the efficacy and tolerability of rufinamide as adjunctive drug for the treatment of a large series of children, adolescents and adults with refractory cryptogenic or symptomatic focal epilepsy. METHODS: Patients were recruited in a prospective, add-on, open-label treatment study from six Italian and one German centers for pediatric and adolescent epilepsy care. Inclusion criteria were: (1) age 3 years or more; (2) diagnosis of cryptogenic or symptomatic focal epilepsy refractory to at least three previous antiepileptic drugs (AEDs), alone or in combination; (3) more than one seizure per month in the last 6 months; (4) use of at least one other AED, but no more than three, at baseline; (5) informed consent from parents and/or caregivers. RESULTS: Sixty-eight patients (40 males, 28 females), aged between 3 and 63 years (mean 19.9 years, median 16.0)±SD 12.58, with cryptogenic (28 pts, 41.2%) or symptomatic focal epilepsy (40 pts, 58.8%), were recruited in the study. After a mean follow-up period of 10.4±10.29 months, twenty-two patients (32.3%) had a 50-99% seizure reduction, and none became seizure-free. Twelve patients (17.6%) had a 25-49% seizure decrease, while in 30 (44.1%) seizure frequency was unchanged. A seizure worsening was reported in 5 patients (7.3%). A better response to rufinamide occurred in frontal lobe seizures (51.6%) and secondary generalized tonic-clonic seizures (50%). CONCLUSION: Rufinamide was effective against focal-onset seizures, particularly in the treatment of secondary generalized frontal lobe seizures.