RESUMEN
AIM: To determine an association between trait anxiety (TA) and variable number tandem repeat (VNTR) polymorphisms in the DRD4 and DAT genes, as well as the prevalence of TA and the risk of cardiovascular diseases (CVD) in 25- to 64-year-old males with TA. SUBJECTS AND METHODS: A representative sample of 25 to 64-year-old males (n = 2149) was examined within the framework of the WHO MONICA program, MONICA-psychosocial subprogram, in 1984, 1988, and 1994. All new-onset arterial hypertension (AH), myocardial infarction (MI), and stroke cases were registered throughout the follow-up study (1984-2008). Spielberger's test was used to estimate the level of TA. The Cox proportional regression model was applied to assess a relative risk. RESULTS: The high level of anxiety (HLA) was 50.9% in the open population of 25 to 64-year-old males. The DRD4 genotype 4/6 and DAT genotype 9/9 were significantly associated with HLA. The latter increased the risk for CVD: it was maximal for AH and stroke within the first five years and for MI within 10 years. CONCLUSION: HLA was significant in the Novosibirsk open population of 25 to 64-year-old males. It is substantially associated with certain VNTR polymorphisms in the DRD4 and DAT genes and considerably increases the risk of CVD.
Asunto(s)
Ansiedad/genética , Enfermedades Cardiovasculares/genética , Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/genética , Personalidad/genética , Receptores de Dopamina D4/genética , Adulto , Ansiedad/epidemiología , Ansiedad/psicología , Enfermedades Cardiovasculares/epidemiología , Enfermedades Cardiovasculares/psicología , Marcadores Genéticos , Genotipo , Encuestas Epidemiológicas , Humanos , Masculino , Persona de Mediana Edad , Polimorfismo Genético/genética , Prevalencia , Riesgo , Factores de Riesgo , Siberia/epidemiología , Organización Mundial de la SaludRESUMEN
The region of intron 2 of the SDF1 gene encoding a chemokine of the CXC subfamily has been resequenced in Galloway, Hereford, and Black Pied cattle. Five of the single-nucleotide polymorphisms (SNPs) that were earlier detected by other authors in various breeds of cattle in North America (99C/G, 128T/C, 206C/T, 267C/G and 313C/T) have been found. The 270insC polymorphic marker has proved to be monomorphic in Russian cattle breeds. Hereford cattle significantly differ from Galloway and Black Pied cattle in the frequencies of some SNP variants and their combinations. The number of SNP combinations in Hereford and Galloway cattle exceeds that in Black Pied cattle.
Asunto(s)
Bovinos/genética , Quimiocina CXCL12/genética , Polimorfismo de Nucleótido Simple/genética , Animales , Marcadores Genéticos , Especificidad de la EspecieRESUMEN
Statistical analysis of the frequency of chromosomes carrying three types (A, B, and C) of porcine endogenous retroviruses (PERV) was based on molecular-genetic testing of populations of domestic pigs and wild boars. Domestic pigs were shown to have higher frequency of PERV and haplotypes containing two and three types of PERV than wild boars.
Asunto(s)
Cromosomas de los Mamíferos/genética , Retroviridae/genética , Porcinos/genética , Animales , Genética de Población/métodos , Haplotipos , Especificidad de la EspecieRESUMEN
Morphometric parameters of the reproductive system have been studied in adult males of four inbred mouse strains and two outbred rat strains after injection of corticosteroids into their mothers at 16 and 18 day of pregnancy. Significant interstrain difference in weight of sex glands was observed. Prenatal injection of corticosteroids decreased high values of features and increased low ones. Hence, the level of corticosteroids during prenatal development plays an important part in regulation of morphometric parameters of the reproductive system of adult rodents. The pattern of action depends on the genotype of an animal and may change under the influence of selection.