Variations of the profile of the nose of the upper lip.

BACKGROUND: The aim of this study is to analyze the path needed to achieve a good aesthetic and functional result in patients treated with orthognathic surgery. METHODS: Seventy-three patients with only III class malocclusion were treated with sagittal split ramus osteotomy and with Le Fort I in only one piece. Through the analysis of anatomical cephalometric tracings, changes in the skeletal base, upper incisor and nose's shape were evaluated. The statistical analysis measurements were calculated for each length and for each angle at T0 (preoperative value) and at T1 (postoperative value). RESULTS: A significant statistical correlation was found mainly between forward movement of the upper maxilla and the outline of the nose, the nasal projection, and the naso-labial angle (NLA). The upper incisor in movements of verticality and inclination did not show any significant correlations with modifications of the NLA. CONCLUSIONS: A significant correlation can be seen between the forward movements of the upper maxilla with the outline of the nose, the nasal projection and the Naso-Labial Angle.

Odontogenic Orofacial Infections.

Acute dental abscess is a frequent and sometimes underestimated disease of the oral cavity. The acute dental abscess usually occurs secondary to caries, trauma, or failed endodontic treatment. After the intact pulp chamber is opened, colonization of the root canals takes place with a variable set of anaerobic bacteria, which colonize the walls of the necrotic root canals forming a specialized mixed anaerobic biofilm. Asymptomatic necrosis is common. However, abscess formation occurs when these bacteria and their toxic products breach into the periapical tissues through the apical foramen and induce acute inflammation and pus formation. The main signs and symptoms of the acute dental abscess (often referred to as a periapical abscess or infection) are pain, swelling, erythema, and suppuration usually localized to the affected tooth, even if the abscess can eventually spread causing a severe odontogenic infection which is characterized by local and systemic involvement culminating in sepsis syndrome. The vast majority of dental abscesses respond to antibiotic treatment, however, in some patients surgical management of the infection may be indicated. In the present work, a retrospective analysis of the patients with dental orofacial infections referred to the Unit of Dentistry and Maxillofacial Surgery of the University of Verona from 1991 to 2011 has been performed.

Bleeding Rate After Tooth Extraction in Patients Under Oral Anticoagulant Therapy.

OBJECTIVES: The aim of this single-cohort prospective study was to evaluate the risk of adverse outcomes after tooth extraction in patients suffering from cardiovascular disorders and under oral anticoagulant therapy with an international normalized ratio within the value of 3.0. METHODS: Two hundred ninety-three patients (mean age of 58.7 years) were enrolled and 560 tooth extractions were performed. Fresh extraction sockets were treated with collagen tablets and sutures. The risk of increased bleeding rate was evaluated for type of drug therapy (acenocoumarol or warfarin), type of cardiovascular diseases, and number of tooth extractions. Level of significance was set at 0.05. RESULTS: The overall bleeding event rate was 6.8%. Among patients who had bleeding events, 4 suffered from valvular disorders, whereas 11 suffered from arrhythmias (8) or cardiomyopathies (3). The remaining 5 patients had a history of cardiomyopathy and arrhythmia.The bleeding events in patients who had more than 2 tooth extractions were significantly higher than those observed in patients who had only 1 tooth extraction (P <0.05). CONCLUSION: Patients who received more than 2 tooth extractions, who were under treatment with acenocoumarol, and who suffered from multiple cardiovascular diseases were at high risk for bleeding events.

Gene Expression of Human Mesenchymal Stem Cells Cultured on Titanium Dental Implant Surfaces.

OBJECTIVE: The study shows how the influence of titanium surfaces on human mesenchymal stem cells differentiates toward osteocytes lineage and how, after growth, on machined titanium disk or etched titanium disk, changes, in gene expression for RUNX1, CTNNB1, SP7, and DLX5. METHODS: Genes were analyzed by means of quantitative real-time polimerase chain reaction. Osseo genic lineage differentiation was also tested by means of the catenin-ß1 immunofluorescence, induced osteoblasts, which represented the internal control. RESULTS: The RUNX1 and SP7 expressions in the induced osteoblasts prove to be different, compared with cells cultured on metallic supports. Moreover, the levels of expression of the runt-related transcription factor 1 and the osterix appeared more down-regulated in cells that grew on a machined titanium surface. In the present experimental model, mRNA expression of DLX5 and CTNNB1 in human mesenchymal stem cells, cultured on each of the titanium surfaces, showed no differences, compared with osteoblast-induced cells. The immunofluorescence scores, for protein expression of beta-catenin in human mesenchymal stem cell treated cells, illustrates significantly improved results with the etched surface. CONCLUSIONS: Present results suggested that different titanium surfaces might induce some differences in terms of gene expression. The only gene analyzed, which proved significant differences between the 2 titanium supports, was SP7; however, the other 3 genes indicating the existence of differences between the 2 titanium groups.