[Procoagulant activity of blood cells in pestivirus infection]. / Prokoaguliantnaia aktivnost' kletok krovi pri pestivirusnykh infektsiiakh.

An increased level of procoagulant activity (PCA) in leukocytes of pigs with acute classical swine fever (CSF) was observed on day 4 postinfection; PCA level normalized during the moribund state. CSF vaccine strain either did not induce an increase of PCA level or induced an increase that persisted for at least 11 days. Time course of PCA changes in the leukocytes from sheep infected with borderline sheep disease was similar to the time course of PCA in acute CSF. In vitro each of the pestiviruses induced an increase in PCA in homologous and heterologous leukocytes.

[Development of delayed-type hypersensitivity to hog cholera]. / Razvitie giperchuvstvitel'nosti zamedlennogo tipa pri klassicheskoi chume svinei

Leukocyte migration inhibition test showed that pigs with classical swine fever develop delayed type hypersensitivity. The highest migration inhibition (65-85%) was observed in animals with the acute form, on day 3 after infection, or directly before death, or in animals immunized with reactogenic strain with clinical signs of disease. In some pigs with acute form the migrating capacity of leukocytes was restored on days 7-8 postinfection. Leukocyte migration inhibition factor is detected in the sera of pigs starting from day 3 after infection with the virulent strain. The degree of delayed type hypersensitivity correlated with the outcome of classical swine fever.

[Procoagulant activity in swine leukocytes, infected with the swine classical plague virus]. / Prokoaguliantnaia aktivnost' v svinykh leikotsitakh, infitsirovannykh virusom klassicheskoi chumy svinei.

An increased level of the procoagulant activity (PCA) has been observed in porcine leukocytes in vitro infected with virulent or vaccine strains of hog cholera virus in comparison with intact cells. PCA was similarly induced in infected leukocytes from swine immune to hog cholera virus. Increased PCA levels were detected in culture medium with leukocytes from intact and immune animals infected in vitro with both virulent and vaccine strains of hog cholera virus in comparison with the PCA levels in culture medium with intact cells.

[Activation of proteinases and acid phosphatase in swine leukocytes infected with the swine classical plague virus]. / Aktivatsiia proteinaz i kisloi fosfatazy v leikotsitakh svin'i, infitsirovannykh virusom klassicheskoi chumy svinei.

The activities of proteinases active at neutral pH and of acid phosphatase increases after freezing and defrosting and hypotonic shock in porcine leukocytes in vitro infected with the classical hog cholera virus in comparison with intact cells. The enzymes in the cells from animals both immune and nonimmune to hog cholera were activated upon infection with both virulent and vaccine strains of the virus. No proteinase activity was detected in the culture medium in which infected porcine leukocytes were cultured. Possible pathological reactions of a cell to viral infection are discussed.

[Natural killers and cytotoxic lymphocytes in classical hog cholera]. / Estestvennye killery i tsitotoksicheskie limfotsity pri klassicheskoi chume svinei.

The formation of immune mechanisms directed at elimination of infected cells and including the activity of natural killers and cytotoxic lymphocytes was assessed in pigs infected with hog cholera virus. In acute disease natural killer activity in the blood is reduced, while in vaccinal process it is increased. Vaccination in parallel with cyclophosphamide immunodepression lead to inhibition of natural killer activity. Leukocytes and lymphocytes of immunized pigs can cause cytolysis of autologous targets infected with hog cholera virus.

[Immune reactions and mechanisms in classical swine fever]. / Immunnye reaktsii i mekhanizmy pri klassicheskoi chume svinei.

The authors review published data on the immune response in classical swine fever infection. Characteristics of the neutralizing antibodies, cytolytic reactions directed at elimination of infected cells, lymphocyte proliferation, and delayed-type hypersensitivity are discussed. Problems of potential theoretical and practical interest are formulated.