[Naltrexone and fluoxetine for maintenance of remission in patients with heroin addiction: a double-blind randomized placebo-controlled trial].

Two hundreds and eighty patients with heroin addiction were randomized into 4 equal groups. Patients of the group 1 received naltrexone (N) in dosage 50 mg/day and fluoxetine (F) in dosage 20 mg/day during 6 months. Group 2 received N/F-placebo (FN), group 3--N-placebo (NP)/F and group 4--NP/FP. All patients underwent a session of individual psychotherapy for the maintenance of remission. Express urine drugs tests were used for remission control. Compliance was controlled by a riboflavin marker. Clinical state, psychiatric status and social functioning were assessed using quantified international scales and tests. To the end of the 6 month course, 43% of patients of group 1, 36% of group 2, 21% of group 3 and 10% of group 4 were in remission. Therefore, N/F was more effective than F/NP (p < 0.01) and FP/NP (p < 0.001); N/FP was more effective than F/NP (p < 0.05) and NP/FP (p < 0.001); F/NP did not differ significantly from NP/FP (p = 0.1); N/F did not differ from N/FP (p = 0.2). However N/F was more effective compared to N/FP only in women, probably, due to the higher baseline levels of depression, anxiety and anhedonia. Naltrexone was superior to placebo and fluoxetine in the efficacy of maintenance of remission and preventing relapse in patients with heroin addiction. The combination of naltrexone and fluoxetine was more effective compared to the monotherapy with naltrexone in women only.

[Changes in fine morphological structures of Escherichia coli, Staphylococcus aureus and spores of Bacillus anthracis vaccine strain STI under the action of the disinfectant "Veltolen"]. / Izmeneniia tonkikh morfologicheskikh struktur Escherichia coli, Staphylococcus aureus i spor Bacillus anthracis vaktsinnogo shtamma STI pod vozdeistviem dezinfektanta "Veltolen".

Changes in fine morphological structures of E. coli, S. aureus and spores of B. anthracis vaccine strain STI under the action of the disinfectant "Veltolen" manufactured by the Closed Joint-Stock Company "Velt", were evaluated. When used at concentrations of 0.0025-0.025%, the preparation induced the loosening of the cell wall in all microorganisms under study, the intensive formation of bubbles on the cell wall surface with their subsequent separation from the cell wall and the formation of "rosettes". In case of more prolonged exposure (up to 60 minutes) and higher concentrations of the preparation these phenomena became more intensive and finally led to the destruction of bacterial cells.