Redefining Lobe-Wise Ground-Glass Opacity in COVID-19 Through Deep Learning and its Correlation With Biochemical Parameters.

During COVID-19 pandemic qRT-PCR, CT scans and biochemical parameters were studied to understand the patients' physiological changes and disease progression. There is a lack of clear understanding of the correlation of lung inflammation with biochemical parameters available. Among the 1136 patients studied, C-reactive-protein (CRP) is the most critical parameter for classifying symptomatic and asymptomatic groups. Elevated CRP is corroborated with increased D-dimer, Gamma-glutamyl-transferase (GGT), and urea levels in COVID-19 patients. To overcome the limitations of manual chest CT scoring system, we segmented the lungs and detected ground-glass-opacity (GGO) in specific lobes from 2D CT images by 2D U-Net-based deep learning (DL) approach. Our method shows accuracy, compared to the manual method (  âˆ¼ 80%), which is subjected to the radiologist's experience. We determined a positive correlation of GGO in the right upper-middle (0.34) and lower (0.26) lobe with D-dimer. However, a modest correlation was observed with CRP, ferritin and other studied parameters. The final Dice Coefficient (or the F1 score) and Intersection-Over-Union for testing accuracy are 95.44% and 91.95%, respectively. This study can help reduce the burden and manual bias besides increasing the accuracy of GGO scoring. Further study on geographically diverse large populations may help to understand the association of the biochemical parameters and pattern of GGO in lung lobes with different SARS-CoV-2 Variants of Concern's disease pathogenesis in these populations.

Diagnosis of Schizophrenia: A Comprehensive Evaluation.

Machine learning models have been successfully employed in the diagnosis of Schizophrenia disease. The impact of classification models and the feature selection techniques on the diagnosis of Schizophrenia have not been evaluated. Here, we sought to access the performance of classification models along with different feature selection approaches on the structural magnetic resonance imaging data. The data consist of 72 subjects with Schizophrenia and 74 healthy control subjects. We evaluated different classification algorithms based on support vector machine (SVM), random forest, kernel ridge regression and randomized neural networks. Moreover, we evaluated T-Test, Receiver Operator Characteristics (ROC), Wilcoxon, entropy, Bhattacharyya, Minimum Redundancy Maximum Relevance (MRMR) and Neighbourhood Component Analysis (NCA) as the feature selection techniques. Based on the evaluation, SVM based models with Gaussian kernel proved better compared to other classification models and Wilcoxon feature selection emerged as the best feature selection approach. Moreover, in terms of data modality the performance on integration of the grey matter and white matter proved better compared to the performance on the grey and white matter individually. Our evaluation showed that classification algorithms along with the feature selection approaches impact the diagnosis of Schizophrenia disease. This indicates that proper selection of the features and the classification models can improve the diagnosis of Schizophrenia.