E-Tattoos: Toward Functional but Imperceptible Interfacing with Human Skin.

The human body continuously emits physiological and psychological information from head to toe. Wearable electronics capable of noninvasively and accurately digitizing this information without compromising user comfort or mobility have the potential to revolutionize telemedicine, mobile health, and both human-machine or human-metaverse interactions. However, state-of-the-art wearable electronics face limitations regarding wearability and functionality due to the mechanical incompatibility between conventional rigid, planar electronics and soft, curvy human skin surfaces. E-Tattoos, a unique type of wearable electronics, are defined by their ultrathin and skin-soft characteristics, which enable noninvasive and comfortable lamination on human skin surfaces without causing obstruction or even mechanical perception. This review article offers an exhaustive exploration of e-tattoos, accounting for their materials, structures, manufacturing processes, properties, functionalities, applications, and remaining challenges. We begin by summarizing the properties of human skin and their effects on signal transmission across the e-tattoo-skin interface. Following this is a discussion of the materials, structural designs, manufacturing, and skin attachment processes of e-tattoos. We classify e-tattoo functionalities into electrical, mechanical, optical, thermal, and chemical sensing, as well as wound healing and other treatments. After discussing energy harvesting and storage capabilities, we outline strategies for the system integration of wireless e-tattoos. In the end, we offer personal perspectives on the remaining challenges and future opportunities in the field.

Blood Pressure Estimation using a Single Channel Bio-Impedance Ring Sensor.

The demand for non-obtrusive, accurate, and continuous blood pressure (BP) monitoring systems is becoming more prevalent with the realization of its significance in preventable cardiovascular disease (CVD) globally. Current cuff-based standards are bulky, uncomfortable, and are limited to discrete recording periods. Wearable sensor technologies such as those using optical photoplethysmography (PPG) have been used to develop blood pressure estimation models through a variety of methods. However, this technology falls short as optical based systems have bias favoring lighter skin tones and lower body fat compositions. Bioimpedance (Bio-Z) is a capable modality of sensing arterial blood flow without implicit inadvertent bias towards individuals. In this paper we propose a ring-based bioimpedance system to capture arterial blood flow from the digital artery of the finger. The ring design provides a more compact wearable device utilizing only a single Bio-Z channel, making it a familiar fit to individuals. Post-processing the acquired Bio-Z signals, we extracted 9 frequency domain features from windowed beat cycles to train subject specific regression models. Results indicate the average mean absolute errors for systolic/diastolic BP to be 4.38/3.63mmHg, consistent with AAMI standards.

A Non-invasive Radial Arterial Compliance Measuring Method using Bio-Impedance.

Arterial compliance is one of the essential indicators of certain types of cardiovascular disease, with both systematic and local compliance exhibiting significance. Radial arterial compliance (RAC) has been regarded as an important type of local compliance in several long-term pathophysiological studies. Bio-Impedance (Bio-Z) is a non-invasive signal which can be used to unobtrusively monitor blood volume changes, captured using wearable sensors. In this paper, a compliance monitoring technique based on Bio-Z is proposed for long-term RAC measurements. Both the distensibility-blood pressure (BP) relation and compliance-mean artery pressure relation are analyzed to observe interparticipant compliance variations from four healthy participants, by controlling the blood flow in a way similar to the oscillometric method for BP measurement. A Bio-Z based compliance index (DBZI) is proposed that can be leveraged for continuous and unobtrusive sensing paradigms. A consecutive seven-day experiment shows that the mean and standard deviation values of the difference between the median value of the Bio-Z based beat-by-beat calculated compliance and DBZI are 0.17 and 0.20 mOhm/mmHg, respectively. This demonstrates the consistency and repeatability of the measurements. The results show that DBZI can track the Bio-Z based compliance with an error of 9.72% and 11.67%, compared to a gold standard, in terms of mean and standard deviation, respectively.