RESUMEN
BACKGROUND: Cancer-specific survival for patients with clinical stage I (CSI) germ cell testicular cancer (GCTC) is outstanding after inguinal orchidectomy regardless the treatment utilized. This study evaluated whether active surveillance (AS) of such patients yielded similar health outcomes to other therapeutic strategies such as adjuvant chemotherapy, radiotherapy or primary retroperitoneal lymphadenectomy as described in the literature. PATIENTS AND METHODS: Patients with CSI GCTC were screened between January 2012 and December 2016. Patients had previously undergone inguinal orchidectomy as the primary treatment and chosen AS as their preferred management strategy after receiving information about all available strategies. RESULTS: Out of 91 patients screened, 82 patients selected AS as their preferred management strategy. Relapse rate in the overall population was 20% (95% CI 12-30) and median time to relapse was 11.5 months (range 1.0-35.0). In patients with seminomatous tumors, relapse rate decreased to 13% and median time to relapse was 13 months; whereas in patients with non-seminomatous tumors, relapse rate was 33% (IA) or 29% (IB) and median time to relapse was 12 months in stage IA and 4.5 months in stage IB patients. All relapses were rescued with three or four cycles of chemotherapy and two also required a retroperitoneal lymphadenectomy. All patients are currently alive and free of disease. CONCLUSIONS: The clinical outcomes of patients with CSI GCTC managed by AS in this series were excellent. This strategy limited the administration of active treatments specifically to the minority of patients who relapsed without compromising performance.
Asunto(s)
Imagen Multimodal/métodos , Neoplasias de Células Germinales y Embrionarias/prevención & control , Orquiectomía/mortalidad , Vigilancia de la Población , Neoplasias Testiculares/prevención & control , Espera Vigilante/estadística & datos numéricos , Adolescente , Adulto , Anciano , Manejo de la Enfermedad , Estudios de Seguimiento , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Neoplasias de Células Germinales y Embrionarias/diagnóstico por imagen , Neoplasias de Células Germinales y Embrionarias/cirugía , Pronóstico , Estudios Retrospectivos , Tasa de Supervivencia , Neoplasias Testiculares/diagnóstico por imagen , Neoplasias Testiculares/cirugía , Espera Vigilante/normas , Adulto JovenRESUMEN
Four cases are reported of upper gastrointestinal hemorrhage caused by Dieulafoy's vascular disease treated in our service over the last 15 years. In all these patients bleeding was from an unusually long artery with a tortuous trajectory through the gastric submucosa that eroded the mucosa and caused blood loss. In 75% of the cases it was located 6 cm below the gastroesophageal junction, near the small curvature. The diagnosis is usually made by endoscopy or during emergency gastrostomy. The most effective therapeutic measure is surgical resection.