Asunto(s)
Receptores de Serotonina/efectos de los fármacos , Antagonistas de la Serotonina/farmacología , Sulfonamidas/farmacología , Tiofenos/farmacología , Administración Oral , Animales , Disponibilidad Biológica , Línea Celular , Humanos , Ratas , Antagonistas de la Serotonina/química , Antagonistas de la Serotonina/farmacocinética , Sulfonamidas/química , Sulfonamidas/farmacocinética , Tiofenos/química , Tiofenos/farmacocinéticaRESUMEN
Starting from a series of 2-aminotetralins 1, a novel series of N-[4-(4-phenylbenzoylamino)butyl]-octahydrobenzoquinolines and hexahydrobenzoindoles with high potency and selectivity for the dopamine D3 receptor has been designed. The effect of ligand chirality on binding affinity has been established. Selected derivatives (e.g. 2o, 2p) show high functional selectivity and enhanced in vivo properties compared to 1.
Asunto(s)
Antagonistas de los Receptores de Dopamina D2 , Tetrahidronaftalenos/química , Animales , Tasa de Depuración Metabólica , Ratas , Receptores de Dopamina D3 , Tetrahidronaftalenos/farmacocinética , Tetrahidronaftalenos/farmacologíaRESUMEN
The operation of the bridge mutually pumped phase conjugator is reported in a planar waveguide structure in photorefractive BaTiO(3). The waveguide was fabricated by the technique of ion implantation, using 1.5-MeVH(+) ions at a dose of 10(16) ions/cm(2). An order of magnitude decrease in response time is observed in the waveguide as compared with typical values obtained in bulk crystals, probably as a result of a combination of the optical confinement within the waveguide and possible modification of the charge-transport properties induced by the implantation process.