Jacketed elastomeric tubes for passive self-regulation of pulsatile flow.

Regulating pulsatile flow is important to achieve optimal separation and mixing and enhanced heat transfer in microfluidic devices, as well as maintaining homeostasis in biological systems. The human aorta, a composite and layered tube made (among others) of elastin and collagen, is an inspiration for researchers who seek an engineering solution for a self-regulation of pulsatile flow. Here, we present a bio-inspired approach showing that fabric-jacketed elastomeric tubes, manufactured using commercially available silicone rubber and knitted textiles, can be used to regulate pulsatile flow. Our tubes are evaluated via incorporation into a mock-circulatory 'flow loop' that replicates the pulsatile fluid flow conditions of an ex-vivo heart perfusion (EVHP) device, a machine used in heart transplants. Pressure waveforms measured near the elastomeric tubing clearly indicated an effective flow regulation. The 'dynamic stiffening' behavior of the tubes during deformation is analyzed quantitatively. Broadly, the fabric jackets allow for the tubes to experience greater magnitudes of pressure and distension without risk of asymmetric aneurysm within the expected operating time of an EVHP. Owing to its highly tunable nature, our design may serve as a basis for tubing systems that require passive self-regulation of pulsatile flow.

Elastomeric tubes with self-regulated distension.

Compliant elastomer tubing with a fabric "jacket" has been essential in various applications as soft robotic actuators, such as in biomedical exomuscles and massage therapy implements. Here, our study shows that a similar design concept can be an effective strategy in realizing passive regulation in the tube's distension, as well as in preventing aneurysm-like asymmetric rupture of the tube. A custom hydraulic pressure testing rig was built to perform experiments. The jacketed tubes initially deform rapidly as pressure increases, but a self-regulation behavior suppresses the tube's continued distension by strain-stiffening of the "jacket". In addition, highly asymmetric distension, common to elastomeric tubes due to imperfection in fabrication, is prevented dramatically by the "jacket". A three-dimensional finite element model predicts the distension of all tested tubes quantitatively across the entire experimental pressure ranges and beyond. Incorporating custom-designed kirigami relief patterns in the "jackets" expands the potential of the elastomeric tubes.

Specific Ion Effects in Polyampholyte Hydrogels Dialyzed in Aqueous Electrolytic Solutions.

Polyampholyte hydrogels (PAHs) constitute a class of physical gels with cross-linking originating from inter- and intrachain ionic cross-linking between countercharged functional groups. In our previous report, we have shown that PAH has the potential to be a gel electrolyte in electrochemical energy storage devices. In this work, we further our understanding of charge-balanced PAH as a host material for gel electrolytes by studying the effect of dialysis on the mechanical properties and ionic conductivities of PAHs, whereas these properties are compared with those of poly(vinyl alcohol) (PVA)-based gel electrolytes. Here, various electrolyte solutions were investigated as dialyzing agents. The ionic species in the electrolytes form ion pairs with countercharged functional groups in PAH, whereas such interactions govern the ionic conductivity and mechanical strength of PAH in various electrolytes. For anions, the trend in ionic interactions follows the Hofmeister series in an exact manner, whereas some anomaly is observed among cations. We anticipate that our study provides a design criterion for fabricating gel electrolytes. In a broader context, this work can shed light on understanding the behavior of PAHs in various operational environments, such as under physiological conditions and in antifouling coatings for biomedical and maritime applications, respectively.