1.
J Comb Chem
; 8(6): 799-801, 2006.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17096565
2.
J Org Chem
; 70(24): 10151-4, 2005 Nov 25.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16292860
RESUMEN
[reaction: see text] A library containing 1200 analogues of 2,6-difunctionalized 2-methyl-2H-1-benzopyran was constructed by using a solid-phase synthesis protocol. Polymer-bound 6-amido-, 6-sulfonamido-, and 6-uredo-functionalized 2-hydroxymethyl-2-methylbenzopyrans 10 were prepared as part of a first-generation diversification step by employing reactions of respective acid halides, sulfonyl chlorides, and isocyanates with the amine precursor 7. Transformations of the resin-bound intermediates 10 by reactions with alkyl and acid halides were then used to produce a diverse series of 2,6-difunctionalized 2-methyl-2H-1-benzopyran analogues 12 and 14.