Interfacial Second-Harmonic Generation via Superposition of Symmetries in a Double-Resonance-Enhanced Plasmonic Nanocavity.

Second-harmonic generation (SHG) has rapidly advanced with the miniaturization of on-chip devices and has found many applications, including optical frequency conversion, nonlinear imaging, and quantum technology. However, owing to the obvious phase-matching constraints involved in nonlinear optical interactions in bulk crystals and the decrease in the length and strength of nonlinear interactions in nanophotonic and surface/interface systems, improving the SHG efficiency and manipulating its optical properties at the nanoscale are challenging tasks. Herein, a monocrystalline silver microplate and nanocube-coupled nanocavity with double-resonance plasmonic modes and an ultrasmall gap were constructed, resulting in efficiently enhanced SHG. In particular, the SHG from the silver microplate (111) is polarization-dependent, and the anisotropy of the SHG in the plasmonic nanocavity can be further controlled via the superposition of symmetries at the interface and plasmonic waveguide-cavity modes. The interfacial SHG provides technology for developing lattice surface atomic arrangement and nanostructure rapid characterization, nonlinear light sources, and on-chip nonlinear nanophotonic devices.

Identification of a highly conserved neutralizing epitope within the RBD region of diverse SARS-CoV-2 variants.

The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing neutralizing antibodies, especially XBB.1.5 and EG.5, which showed exceptional immune evasion properties. Here, we identify a highly conserved neutralizing epitope targeted by a broad-spectrum neutralizing antibody BA7535, which demonstrates high neutralization potency against not only previous variants, such as Alpha, Beta, Gamma, Delta and Omicron BA.1-BA.5, but also more recently emerged Omicron subvariants, including BF.7, CH.1.1, XBB.1, XBB.1.5, XBB.1.9.1, EG.5. Structural analysis of the Omicron Spike trimer with BA7535-Fab using cryo-EM indicates that BA7535 recognizes a highly conserved cryptic receptor-binding domain (RBD) epitope, avoiding most of the mutational hot spots in RBD. Furthermore, structural simulation based on the interaction of BA7535-Fab/RBD complexes dissects the broadly neutralizing effect of BA7535 against latest variants. Therapeutic and prophylactic treatment with BA7535 alone or in combination with BA7208 protected female mice from the circulating Omicron BA.5 and XBB.1 variant infection, suggesting the highly conserved neutralizing epitope serves as a potential target for developing highly potent therapeutic antibodies and vaccines.

Plasmon enhanced light-matter interaction of rice-like nanorods by a cube-plate nanocavity.

Plasmonic nanocavity is widely used for enhancing light-matter interaction. Here, an efficient plasmonic nanocavity of the cube-plate system is constructed for the fluorescence enhancement of rice-like CdSe/CdS nanorods (NRs) with tunable emission wavelength. Over ten thousand times fluorescence enhancement is achieved with the assistance of the plasmonic nanocavity. Additionally, a small splitting effect is observed in both photoluminescence and scattering spectra of the NRs in the nanocavity owing to the intermediate coupling effect between the NRs and plasmonic nanocavity, which provides a potential application for optical signal enhancement and strong light-matter interaction.

Correction: Plasmon enhanced light-matter interaction of rice-like nanorods by a cube-plate nanocavity.

[This corrects the article DOI: 10.1039/D1NA00777G.].

Twinned-Au-tip-induced growth of plasmonic Au-Cu Janus nanojellyfish in upconversion luminescence enhancement.

The metallic Janus nanoparticle is an emerging plasmonic nanostructure that has attracted attention in the fields of materials science and nanophotonics. The instability of the Cu nanostructure leads to very complex nucleation and growth kinetics, and synthesis of Cu Janus nanoparticle has challenges. Here, we report a new method for synthesis of Au-Cu Janus nanojellyfish (JNF) by using twinned tips of Au nanoflower (NF) as seeds. The twinned nanotip of the Au NF and the large lattice mismatch between Au and Cu can induce formation of twin defects during the growth process, resulting in asymmetric deposition of Cu atoms. The symmetry-breaking using different sizes of Au NF and Cu nanodomains within the Au-Cu JNF can controllably change the localized surface plasmon resonance (LSPR) modes. The asymmetric Au-Cu JNF can induce plasmon coupling between dipolar and multipolar modes, which leads to clear electric-field enhancement in the near-infrared region. An Au-Cu JNF with multiple LSPR modes was chosen to simultaneously match the excitation and emission bands of the lanthanide-doped upconversion nanoparticles (UCNPs). A 5000-fold enhancement of the upconversion luminescence was achieved by using single plasmonic Au-Cu JNF. The Au-Cu JNF can also provide a guide for new metallic Janus nanoparticles in the fields of plasmonic, photothermal conversion, and nanomotors.