1.
Bioorg Med Chem Lett
; 14(7): 1717-20, 2004 Apr 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15026057
RESUMEN
Potent small molecule biaryl diketopiperazine FSH receptor agonists such as 10c (EC(50)=13 nM) and 11f (EC(50)=1.2 nM) were discovered through the design, synthesis and evaluation of three biaryl diketopiperazine optimization libraries with over 300 compounds. These libraries were prepared via solid-phase parallel synthesis using a cyclization-release method.