Validating the efficacy and value proposition of mental fitness vocal biomarkers in a psychiatric population: prospective cohort study.

Background: The utility of vocal biomarkers for mental health assessment has gained increasing attention. This study aims to further this line of research by introducing a novel vocal scoring system designed to provide mental fitness tracking insights to users in real-world settings. Methods: A prospective cohort study with 104 outpatient psychiatric participants was conducted to validate the "Mental Fitness Vocal Biomarker" (MFVB) score. The MFVB score was derived from eight vocal features, selected based on literature review. Participants' mental health symptom severity was assessed using the M3 Checklist, which serves as a transdiagnostic tool for measuring depression, anxiety, post-traumatic stress disorder, and bipolar symptoms. Results: The MFVB demonstrated an ability to stratify individuals by their risk of elevated mental health symptom severity. Continuous observation enhanced the MFVB's efficacy, with risk ratios improving from 1.53 (1.09-2.14, p=0.0138) for single 30-second voice samples to 2.00 (1.21-3.30, p=0.0068) for data aggregated over two weeks. A higher risk ratio of 8.50 (2.31-31.25, p=0.0013) was observed in participants who used the MFVB 5-6 times per week, underscoring the utility of frequent and continuous observation. Participant feedback confirmed the user-friendliness of the application and its perceived benefits. Conclusions: The MFVB is a promising tool for objective mental health tracking in real-world conditions, with potential to be a cost-effective, scalable, and privacy-preserving adjunct to traditional psychiatric assessments. User feedback suggests that vocal biomarkers can offer personalized insights and support clinical therapy and other beneficial activities that are associated with improved mental health risks and outcomes.

Depression Classification Using n-Gram Speech Errors from Manual and Automatic Stroop Color Test Transcripts.

While the psychological Stroop color test has frequently been used to analyze response delays in temporal cognitive processing, minimal research has examined incorrect/correct verbal test response pattern differences exhibited in healthy control and clinically depressed populations. Further, the development of speech error features with an emphasis on sequential Stroop test responses has been unexplored for automatic depression classification. In this study which uses speech recorded via a smart device, an analysis of и-gram error sequence distributions shows that participants with clinical depression produce more Stroop color test errors, especially sequential errors, than the healthy controls. By utilizing и-gram error features derived from multisession manual transcripts, experimentation shows that trigram error features generate up to 95% depression classification accuracy, whereas an acoustic feature baseline achieve only upwards of 75%. Moreover, и-gram error features using ASR transcripts produced up to 90% depression classification accuracy.

A Study of Novel Exploratory Tools, Digital Technologies, and Central Nervous System Biomarkers to Characterize Unipolar Depression.

Background: Digital technologies have the potential to provide objective and precise tools to detect depression-related symptoms. Deployment of digital technologies in clinical research can enable collection of large volumes of clinically relevant data that may not be captured using conventional psychometric questionnaires and patient-reported outcomes. Rigorous methodology studies to develop novel digital endpoints in depression are warranted. Objective: We conducted an exploratory, cross-sectional study to evaluate several digital technologies in subjects with major depressive disorder (MDD) and persistent depressive disorder (PDD), and healthy controls. The study aimed at assessing utility and accuracy of the digital technologies as potential diagnostic tools for unipolar depression, as well as correlating digital biomarkers to clinically validated psychometric questionnaires in depression. Methods: A cross-sectional, non-interventional study of 20 participants with unipolar depression (MDD and PDD/dysthymia) and 20 healthy controls was conducted at the Centre for Human Drug Research (CHDR), the Netherlands. Eligible participants attended three in-clinic visits (days 1, 7, and 14), at which they underwent a series of assessments, including conventional clinical psychometric questionnaires and digital technologies. Between the visits, there was at-home collection of data through mobile applications. In all, seven digital technologies were evaluated in this study. Three technologies were administered via mobile applications: an interactive tool for the self-assessment of mood, and a cognitive test; a passive behavioral monitor to assess social interactions and global mobility; and a platform to perform voice recordings and obtain vocal biomarkers. Four technologies were evaluated in the clinic: a neuropsychological test battery; an eye motor tracking system; a standard high-density electroencephalogram (EEG)-based technology to analyze the brain network activity during cognitive testing; and a task quantifying bias in emotion perception. Results: Our data analysis was organized by technology - to better understand individual features of various technologies. In many cases, we obtained simple, parsimonious models that have reasonably high diagnostic accuracy and potential to predict standard clinical outcome in depression. Conclusion: This study generated many useful insights for future methodology studies of digital technologies and proof-of-concept clinical trials in depression and possibly other indications.

Automatic Detection of COVID-19 Based on Short-Duration Acoustic Smartphone Speech Analysis.

Currently, there is an increasing global need for COVID-19 screening to help reduce the rate of infection and at-risk patient workload at hospitals. Smartphone-based screening for COVID-19 along with other respiratory illnesses offers excellent potential due to its rapid-rollout remote platform, user convenience, symptom tracking, comparatively low cost, and prompt result processing timeframe. In particular, speech-based analysis embedded in smartphone app technology can measure physiological effects relevant to COVID-19 screening that are not yet digitally available at scale in the healthcare field. Using a selection of the Sonde Health COVID-19 2020 dataset, this study examines the speech of COVID-19-negative participants exhibiting mild and moderate COVID-19-like symptoms as well as that of COVID-19-positive participants with mild to moderate symptoms. Our study investigates the classification potential of acoustic features (e.g., glottal, prosodic, spectral) from short-duration speech segments (e.g., held vowel, pataka phrase, nasal phrase) for automatic COVID-19 classification using machine learning. Experimental results indicate that certain feature-task combinations can produce COVID-19 classification accuracy of up to 80% as compared with using the all-acoustic feature baseline (68%). Further, with brute-forced n-best feature selection and speech task fusion, automatic COVID-19 classification accuracy of upwards of 82-86% was achieved, depending on whether the COVID-19-negative participant had mild or moderate COVID-19-like symptom severity.

On the use of cellular telephony for audio interaction with animals.

Playback is an important method of surveying animals, assessing habitats and studying animal communication. However, conventional playback methods require on-site observers and therefore become labour-intensive when covering large areas. Such limitations could be circumvented by the use of cellular telephony, a ubiquitous technology with increasing biological applications. In addressing concerns about the low audio quality of cellular telephones, this paper presents experimental data to show that owls of two species (Strix varia and Megascops asio) respond similarly to calls played through cellular telephones as to calls played through conventional playback technology. In addition, the telephone audio recordings are of sufficient quality to detect most of the two owl species' responses. These findings are a first important step towards large-scale applications where networks of cellular phones conduct real-time monitoring tasks.