RESUMEN
AIM: To determine the ability of sheep to mobilise their body reserves after being deprived of feed prior to transport for slaughter. METHODS: A total of 240 3- and 4-year-old cull ewes were held off pasture for 0, 9, 18 or 30 hours (n=60 per group) then transported 1 hour by road, unloaded and washed, held in lairage for 3 hours then slaughtered. Blood samples were collected from a subsample of 60 unfasted ewes 1 week earlier, and from all ewes at exsanguination to determine concentrations of serum metabolites indicative of adaptation to fasting. In addition, several attributes of carcass quality were measured. RESULTS: At slaughter, increased time off pasture prior to transport resulted in no change in glucose concentrations in serum (p=0.140). There were differences (p<0.001) between the group fasted for 30 compared with 0 hours in mean concentrations of free fatty acids (0.98 (SD 0.32) vs. 0.58 (SD 0.23) mmol/L), ß-hydroxybutyrate (0.69 (SD 0.17) vs. 0.42 (SD 0.11) mmol/L), triglycerides (0.29 (min 0.13, max 0.83) vs. 0.22 (min 0.06, max 0.96) mmol/L) and urea (10.17 (SD 1.80) vs. 6.94 (SD 2.03) mmol/L). Different periods of feed deprivation had no effect (p>0.05) on carcass weights (mean 22.7, min 13.2, max 32.9 kg) or dressing out percentages (mean 40.9, min 27, max 49%). Meat ultimate pH was unaffected (p>0.05) by the period of feed deprivation but meat became darker (p<0.05) and had reduced redness (p<0.001) with increasing time off feed. CONCLUSIONS: The results suggest that sheep in variable body condition adapted to the periods of feed deprivation by mobilising their energy reserves without any evidence of metabolic depletion (e.g. depleted blood glucose or high meat pH). However, being deprived of feed they probably experience a degree of hunger.
Asunto(s)
Privación de Alimentos/fisiología , Ovinos/fisiología , Mataderos , Alimentación Animal , Animales , Composición Corporal , Peso Corporal , Femenino , Ovinos/sangre , Factores de Tiempo , TransportesRESUMEN
Partial neutralization of bone morphogenetic protein 15 (BMP15) bioactivity by immunization is known to increase ovulation rate in sheep. However, it remains uncertain whether BMP15 vaccination would be a suitable procedure for increasing lambing rate. The aim of this study was to compare the efficacy of a BMP15 vaccination treatment on lamb production to that of commercially-available androstenedione-based vaccines that are used for this purpose. Ewes were immunized for 3 yr against androstenedione, BMP15, or no antigen (control). Vaccination with androstenedione or BMP15 altered (P < 0.05) ovulation rate as well as litter size at midpregnancy, birth, and weaning compared with controls. No differences were detected in the proportions of ewes conceiving in the first cycle or partial failure of multiple ovulations. Both gender and litter size affected birth weight of the lamb (P < 0.05), but no effect of treatment was found. Growth rate was significantly affected (P < 0.05) by gender, birth weight, and the number of lambs raised, but not treatment. In conclusion, immunization against either androstenedione or BMP15 increased ovulation rate. Androstenedione vaccination also increased the number of lambs weaned (P < 0.05). Bone morphogenetic protein 15 vaccination altered the pattern of the number of lambs weaned, but no increase in lamb production was observed as more ewes produced zero or three lambs. Overall, androstenedione or BMP15 vaccination did not significantly affect embryo or fetal survival or lamb performance independently of the effects of these treatments on ovulation rate.
Asunto(s)
Androstenodiona/inmunología , Proteína Morfogenética Ósea 15/inmunología , Inducción de la Ovulación/veterinaria , Ovinos/fisiología , Vacunas , Animales , Peso al Nacer , Femenino , Tamaño de la Camada , Inducción de la Ovulación/métodos , Parto , Embarazo , Ovinos/inmunología , DesteteRESUMEN
AIMS: To test the efficacy of a commercially available and an experimental vaccine against Johne's disease in young red deer (Cervus elaphus), using experimental challenge with live virulent Mycobacterium avium subsp paratuberculosis (M. ptb), measure injection-site reactions, and assess the effects of vaccination and challenge on results of subsequent skin tests and ancillary blood tests for bovine tuberculosis (Tb). METHODS: Ninety 6-8-week-old red deer fawns were randomly allocated to three equal groups of 30, and received either a 1-ml S/C injection of either a commercially available whole-cell killed vaccine with a mineral-oil adjuvant (COM), or a live attenuated M. ptb experimental vaccine with a lipid adjuvant (EXP), or were unvaccinated controls. Ten weeks later (Week 10), all 90 fawns received an oral challenge with approximately 10(8) cfu of a bovine strain of M. ptb daily for 4 days. The fawns were regularly weighed and monitored for clinical signs of Johne's disease, and regularly blood-sampled and tested for antibodies to M. ptb, using the Paralisa test, an IgG1 ELISA, and for antibodies to Mycobacterium bovis, using a similar test. A mid-cervical tuberculin skin test (MCT) was administered at Week 23, and comparative cervical skin tests (CCTs) were administered at Weeks 37 and 57. All animals were electively killed at Week 59, injection sites inspected, gastrointestinal tracts examined for gross lesions, and samples taken for culture and histopathology. RESULTS: There were no clinical cases of Johne's disease but, at slaughter, more gross lesions in intestinal lymph nodes were observed in Control (20%) than COM animals (0%; p<0.05). This latter group also had less severe histopathological lesions in samples of intestines and lymph nodes compared with the Control group (p<0.05), but not deer in the EXP group. Over 89% of deer in all three groups were shown by culture to be infected with M. ptb, while only 21-33% of faecal samples were culture-positive. Time to positive culture was longer for COM vs EXP and Control groups (p<0.01), reflecting fewer M. ptb organisms in samples from the ileocaecal valve (ICV) in that group. Almost all (>or=90%) deer reacted to the MCT at Week 23, and there were no significant differences between groups. One or two deer in each group were classified as Tb reactors to the CCT at Week 37, and none were classified as Tb reactors to the CCT at Week 57. At the time of challenge, over 50% of deer in the COM group were classified as positive (9/28) or suspicious (7/28) for M. ptb antibodies in the Paralisa test, one animal in the EXP group was classified as suspicious, and all the Controls were negative. From Week 23 to the end of the trial, 25/28 (89%) deer in the COM group were Paralisa-positive or -suspicious. The proportion of animals in the EXP and Control groups that were Paralisa-positive peaked at Week 39 (60% and 55%, respectively). The majority of deer in the COM group had significant levels of antibody to M. bovis 10 weeks after vaccination, while the proportion of M. bovis-antibody positive Control deer rose gradually throughout the trial, reaching 23/30 (77%) at slaughter. Injection-site lesions in COM deer ranged from 10-38 mm in diameter 4 weeks after vaccination, and then resolved. Minimal injection-site lesions were observed in EXP deer. At slaughter, 14 months after vaccination, 19/28 deer in the COM group had 5-15-mm nodules that were easily trimmed from the carcass. CONCLUSIONS: The experimental challenge with M. ptb produced subclinical Johne's disease in the majority of deer, but did not cause any clinical disease. The number and severity of gross and microscopic lesions was significantly reduced in the COM compared with Control and EXP groups; vaccination of the EXP group did not appear to give significant protection. Deer vaccinated with the commercial vaccine are likely to give a false-positive reaction to the MCT but should have an avian reaction to the CCT, if it is carried out >12 months after vaccination. Most of the deer vaccinated with the commercial vaccine produced significant levels of antibodies against both M. ptb and M. bovis, which interfered with ancillary Tb tests. If this vaccine or similar oil-based vaccines are used on deer farms in the future, it may be advisable to only vaccinate animals destined for slaughter, that would not need to be Tb-tested, but would be 'works-monitored' for evidence of Tb instead.
Asunto(s)
Anticuerpos Antibacterianos/sangre , Vacunas Bacterianas/inmunología , Ciervos , Mycobacterium avium subsp. paratuberculosis/inmunología , Paratuberculosis/prevención & control , Prueba de Tuberculina/veterinaria , Animales , Vacunas Bacterianas/efectos adversos , Recuento de Colonia Microbiana/veterinaria , Ciervos/inmunología , Susceptibilidad a Enfermedades , Reacciones Falso Positivas , Heces/microbiología , Femenino , Ganglios Linfáticos/patología , Masculino , Mycobacterium avium subsp. paratuberculosis/patogenicidad , Paratuberculosis/patología , Distribución Aleatoria , Índice de Severidad de la Enfermedad , Factores de Tiempo , Resultado del Tratamiento , Prueba de Tuberculina/normas , Vacunas Atenuadas/efectos adversos , Vacunas Atenuadas/inmunologíaRESUMEN
The parasitoid, Microctonus aethiopoides Loan (Hymenoptera: Braconidae) was introduced into New Zealand in 1982 to control the alfalfa pest, Sitona discoideus Gyllenhal (Coleoptera: Curculionidae). Studies have shown that a number of nontarget weevil species are attacked in the field by this parasitoid. A field study was carried out to investigate nontarget parasitism by M. aethiopoides over an altitudinal sequence from the target host habitat (alfalfa) into native grassland. Three locations were selected for the study, and at each, the alfalfa growing in the valley floor was sampled annually for parasitism of the target pest that ranged between 17 and 78%. At progressively higher altitudes, three further grassland sites at each location were sampled monthly during spring to autumn for up to 6 yr. Weevil densities were estimated, species identified, and dissections carried out to determine reproductive status and parasitism. Almost 12,000 weevils were collected during the study, which were identified as 36 species in total from the three locations. Eight weevil species were found to be parasitized, including S. discoideus, the target host that was found at all sites. Parasitism of nontarget species was approximately 2% overall but varied with location, site, and season. Substantial nontarget parasitism was found at only one of the locations, with up to 24% parasitism of a native weevil, Nicaeana fraudator Broun (Coleoptera: Curculionidae), recorded. Another species, Irenimus egens (Broun) (Coleoptera: Curculionidae), was also found at this location at similar population densities but was attacked far less by M. aethiopoides. Results are discussed in relation to weevil phenology.
Asunto(s)
Escarabajos/parasitología , Himenópteros/fisiología , Control Biológico de Vectores/métodos , Altitud , Animales , Nueva Zelanda , Factores de TiempoRESUMEN
Bone density (BD) is an important factor in osteoporotic fracture risk in humans. However, BD is a complex trait confounded by environmental influences and polygenic inheritance. Sheep provide a potentially useful model for studying differences in BD, as they provide a means of circumventing complex environmental factors and are a similar weight to humans. The aims of this study were to establish whether there is genetic variation in BD in sheep and then to localise quantitative trait loci (QTLs) associated with this variation. We also aimed to evaluate the relationship between fat and muscle body components and BD in sheep. Results showed that there was significant (P < 0.01) genetic variation among Coopworth sheep sires for BD. This genetic difference was correlated (P < 0.01) with body weight and muscle mass. A number of QTLs exceeding the suggestive threshold were identified (nine in total). Of these, two (chromosomes 1, P < 0.05; chromosome 24, P < 0.01) were significant using genome-wide permutation significance thresholds (2000 iterations). The position of the QTL on chromosome 24 coincided with a number of other body composition QTLs, indicating possible pleiotropic effects or the presence of multiple genes affecting body composition at that site. This study shows that sheep are potentially a useful model for studying the genetics of BD.
Asunto(s)
Densidad Ósea/genética , Ovinos/genética , Ovinos/metabolismo , Animales , Femenino , Fracturas Óseas/etiología , Variación Genética , Humanos , Masculino , Modelos Animales , Osteoporosis/complicaciones , Osteoporosis/genética , Osteoporosis/metabolismo , Fenotipo , Sitios de Carácter Cuantitativo , Especificidad de la EspecieRESUMEN
A laboratory study of aspects of parasitoid host acceptance, suitability and physiological regulation in natural and novel host species was carried out to investigate the degree of variability encountered with different hosts and to determine the value of such observations in host range determination. The parasitoid Microctonus aethiopoides Loan was exposed to a natural host, Sitona discoideus Gyllenhal (Coleoptera: Curculionidae) and three novel hosts, the New Zealand native Nicaeana cervina Broun, the introduced weed biological control agent Rhinocyllus conicus (Froehlich), and a congeneric pest species, Sitona lepidus Gyllenhal (all Coleoptera: Curculionidae). Per cent parasitism of these species was 54%, 43%, 39% and 0%, respectively. The results indicated that for both S. discoideus and R. conicus more males than females were parasitized (69% cf. 45%, and 49% cf. 32% respectively) but host size was not a significant factor. Overall, superparasitism was recorded in about 29% of parasitized weevils and there was evidence that host discrimination to avoid superparasitism occurred in the natural host. Conversely, superparasitism occurred more frequently than would be expected in N. cervina (42%) coupled with higher survival of larvae in superparasitized hosts in this species. The frequency distribution of attack of R. conicus by M. aethiopoides was not different from random. Parasitoid development was more rapid in the natural host, S. discoideus, and parasitoid size was positively correlated with host size. There was a strong positive relationship between parasitoid larval survival and the presence of teratocytes in all hosts. Host fecundity and fertility were reduced by parasitism for most species, and in some cases, by exposure to parasitoids in the absence of detectable parasitism. It was concluded that laboratory observations can provide useful information on the compatibility between host and parasitoid which can complement traditional host range tests to predict field host range.
Asunto(s)
Escarabajos/parasitología , Avispas/fisiología , Animales , Escarabajos/fisiología , Femenino , Fertilidad , Vuelo Animal , Masculino , Músculo Esquelético/crecimiento & desarrollo , Avispas/crecimiento & desarrolloRESUMEN
Comparative experiments on parasite burdens present difficulties for modelling and interpretation: data tend to have highly skewed distributions, some standard methods of testing for effects have low power, and there is a need to make allowance for dependencies among the various measurements. Randomization testing and canonical variates analysis are advocated as a means of minimising these problems.
Asunto(s)
Ciervos/parasitología , Infecciones por Dictyocaulus/parasitología , Ostertagiasis/veterinaria , Abomaso/parasitología , Albendazol/farmacología , Albendazol/uso terapéutico , Animales , Antinematodos/farmacología , Antinematodos/uso terapéutico , Dictyocaulus/efectos de los fármacos , Dictyocaulus/crecimiento & desarrollo , Infecciones por Dictyocaulus/tratamiento farmacológico , Infecciones por Dictyocaulus/inmunología , Análisis Discriminante , Susceptibilidad a Enfermedades , Heces/parasitología , Inmunidad Innata , Intestino Grueso/parasitología , Intestino Delgado/parasitología , Pulmón/parasitología , Análisis Multivariante , Ostertagia/efectos de los fármacos , Ostertagia/crecimiento & desarrollo , Ostertagiasis/inmunología , Ostertagiasis/parasitología , Recuento de Huevos de Parásitos/veterinaria , Distribución AleatoriaRESUMEN
AIMS: To measure the efficacy of a pour-on formulation of moxidectin against lungworm and abomasal parasites in weaner wapiti x red deer and to compare this with its efficacy in weaner red deer. METHODS: Six red and six wapiti hybrid deer, naturally infected with lungworm and gastro-intestinal parasites, were treated with pour-on moxidectin at 500 microg/kg body weight and slaughtered 14 or 16 days later, along with six red and six wapiti hybrid untreated control deer. Total worm counts were performed on the lungs, abomasum and abomasal digest of each deer. RESULTS: The efficacy of moxidectin pour-on was 100% against adult and immature lungworms (Dictyocaulus viviparus) in red deer, and 100% and 99.7% effective against adult and immature lungworm in wapiti hybrid deer. The efficacy of moxidectin pour-on was 100, 100, 99.9 and 99.9% respectively against adult, fifth stage, late fourth stage and early fourth stage larvae of Ostertagia-type nematodes (assumed to be Ostertagia, Spiculopteragia, Skrjabinagia and Apteragia spp.) in both red and wapiti hybrid deer. CONCLUSIONS: The pour-on formulation of moxidectin, at 500 microg/kg body weight, is highly effective against mature and immature lungworms and abomasal nematodes in wapiti hybrid deer and equally effective in red deer.
RESUMEN
Introduction of the Inverdale prolificacy gene (FecXI) could markedly improve reproductive efficiency in commercial flocks, but as homozygous carrier Inverdale ewes are infertile, it is imperative that these animals are identified at an early age and excluded from breeding stock. As the ovaries of homozygous carrier ewes are nonfunctional, there are wide differences in reproductive hormone levels between these and other Inverdale genotypes. This study assesses the accuracy of using hormone concentrations alone, to identify infertile homozygous ewe lambs. Ewe lambs were blood sampled at 2, 5 and/or 8 months of age, and plasma analyzed for follicle-stimulating hormone (FSH), luteinizing hormone (LH) and inhibin content. These animals were either the offspring of both known carrier rams and known carrier ewes, and therefore would be either homozygous (II) or heterozygous (I+) for the Inverdale gene (group 1, N = 122), or had one parent that was a carrier and therefore would be either heterozygous or noncarriers (++) of the gene (group 2, N = 32). Animals were designated as either II or I+/++ on the basis of their plasma hormone concentrations. Inverdale genotype was also assigned from laparoscopic observation of the ovaries at each of these occasions. Definitive assignment of genotype was made at laparoscopy as adults during the breeding season. On the basis of laparoscopy as adults, 62 (51%) lambs in group 1 were identified as homozygous and 60 (49%) as heterozygous. At all three ages, both mean FSH and mean LH concentrations were significantly higher in II than in I+ lambs. Mean inhibin concentrations were significantly lower in II lambs at 8 months, but did not differ significantly between genotypes at 2 or 5 month of age. The use of discriminant analysis techniques to segregate individual animals in group 1 on the basis of their plasma FSH and LH concentrations, correctly identified Inverdale genotype in 50/52 (96%) lambs at 2 months, 75/79 (95%) at 5 months and 118/122 (97%) at 8 months of age. Discriminant analysis was equally effective for segregating II ewe lambs (group 1) from fertile ewe lambs of I+ and ++ genotype (group 2, 97% correct at 5 months and 98% at 8 months). At no stage did inclusion of inhibin concentrations into the discriminant function alter the number of homozygous ewes misclassified. This demonstrates that infertile homozygous ewe lambs can accurately be distinguished from their fertile flockmates by using plasma concentrations of gonadotrophins alone, and that this can be achieved from as early as 2 months of age.
Asunto(s)
Hormona Folículo Estimulante/sangre , Homocigoto , Infertilidad Femenina/genética , Inhibinas/sangre , Hormona Luteinizante/sangre , Ovinos/sangre , Ovinos/genética , Factores de Edad , Animales , Estudios de Cohortes , Femenino , Hormona Folículo Estimulante/metabolismo , Genotipo , Infertilidad Femenina/diagnóstico , Infertilidad Femenina/veterinaria , Inhibinas/metabolismo , Hormona Luteinizante/metabolismo , MasculinoRESUMEN
Taenia hydatigena and Echinococcus granulosus in dogs have been used as a model to evaluate the response of these parasites to increasing doses of mebendazole in different dose forms (powder, micronized powder and tablets of micronized powder). Overall the micronized powder proved to be the most active, the tablets less so and the normal powder least active. Statistical confirmation was obtained that the use of this drug in different dose forms changed the rate of the response, suggesting that in the treatment of human hydatid disease caused by Echinococcus spp and cysticercosis caused by Taenia solium, the dosage form may be a vital factor in the drug's efficacy.
Asunto(s)
Infecciones por Cestodos/tratamiento farmacológico , Mebendazol/uso terapéutico , Animales , Disponibilidad Biológica , Perros , Técnicas In Vitro , Mebendazol/administración & dosificación , Tamaño de la Partícula , PolvosRESUMEN
Praziquantel was evaluated for its larvicidal activity against naturally or experimentally induced Taenia hydatigena infections in sheep. The major criterion used for assessing efficacy was an estimate of the dose rate required to free 90 per cent of the sheep from infection (ED90) together with a 95 per cent confidence interval. With both light and heavy infections of three-month-old T hydatigena in lambs up to 12 months old, many larvae were killed. The ED90 and 95 per cent confidence limits for six-month-old and aged organisms was estimated to be 13.1 (5.5 to 31.4) mg/kg and 6.1 (2.4 to 15.5) mg/kg, respectively. Equivalent data for the ED50 were 3.4 (1.4 to 8.3) mg/kg and 1.3 (0.3 to 5.4) mg/kg, respectively. It was established that one of the factors involved in the efficacy of praziquantel was associated with the age of the larvae at the time of treatment, the drug being markedly more effective against older than younger organisms.
Asunto(s)
Cisticercosis/veterinaria , Isoquinolinas/administración & dosificación , Praziquantel/administración & dosificación , Enfermedades de las Ovejas/tratamiento farmacológico , Teniasis/veterinaria , Factores de Edad , Animales , Cisticercosis/tratamiento farmacológico , Relación Dosis-Respuesta a Droga , Femenino , Praziquantel/farmacología , Praziquantel/uso terapéutico , Ovinos , Taenia/efectos de los fármacos , Teniasis/tratamiento farmacológicoRESUMEN
Lambs reared from birth in a 'tapeworm-free' unit were immunised at three months old by a parenteral injection of the embryos of Taenia hydatigena. Subsequently, they were grazed with unimmunised control animals on an egg-free pasture. At one, three, six, nine, 12 or 15 months after immunisation, groups of the treated and control animals were grazed for eight weeks on an experimental egg-contaminated pasture. Strong immunity was shown up to three months after immunisation by the presence of only a few pinhead lesions in the lamb's liver. At six and nine months after immunisation, the lesions were similar in size to those in the control animals. While a few organisms reached the abdominal cavity in animals grazed six and nine months after immunisation, no viable cysts were found until 12 months. Seven-year-old sheep, which had been naturally infected with T hydatigena at an early age but had rarely ingested eggs since, were also grazed on the egg-contaminated pasture. Populations of original and superimposed metacestodes were observed in the abdominal cavity of some of them. The first experiment investigated the duration of immunity to the embryo, reorganising larva and metacestode in the absence of further egg infections. The second experiment confirmed that original and superimposed cyst populations can coexist.
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Enfermedades de las Ovejas/inmunología , Ovinos/inmunología , Teniasis/veterinaria , Animales , Inmunidad Activa , Inmunización/veterinaria , Hígado/parasitología , Enfermedades de las Ovejas/parasitología , Taenia/inmunología , Teniasis/inmunología , Teniasis/parasitología , Factores de TiempoRESUMEN
A review has been made of the advances in knowledge on the treatment of tapeworm infections of man and animals from the time of the introduction to dichlorophen in 1956. This opened up the era of out-patient treatment for human tapeworm infections. The drugs studied have been compared, where possible, on the basis of estimates of the single dose ED90 or the number of treatments required to reach that efficacy at safe dose levels. During the period under review, niclosamide, introduced in 1960 has been regarded as the drug of choice for the treatment of human tapeworm infections with paromomycin as a possible alternative. The bunamidine salts, introduced in 1966 permitted the treatment of Echinococcus spp in dogs. Several treatments were required to achieve acceptable efficacy. In 1975 praziquantel was introduced and based on the ED90, a single dose at no more than 10mg/kg removed all tapeworms responsible for the cestode zoonoses and for which data are available with the exception of H. nana and D. latum; these require a higher dose rate. In the mid 1970s, several benzimidazoles and praziquantel were shown to have activity against metacestodes. This has opened up a new field of research promising a practical outcome. No progress has been made during the period under review in finding effective ovicides.
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Animales Domésticos/parasitología , Animales de Laboratorio/parasitología , Anticestodos/uso terapéutico , Infecciones por Cestodos/tratamiento farmacológico , Animales , Anticestodos/administración & dosificación , Infecciones por Cestodos/veterinaria , Combinación de Medicamentos , HumanosRESUMEN
Dogs infected with Echinococcus granulosus were treated with praziquantel by three routes and at different dosage rates. The results indicated that the dog was of similar efficacy when administered by the oral and intramuscular routes, but less effective by the subcutaneous route.
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Enfermedades de los Perros/tratamiento farmacológico , Equinococosis/veterinaria , Isoquinolinas/administración & dosificación , Praziquantel/administración & dosificación , Administración Oral , Animales , Perros , Equinococosis/tratamiento farmacológico , Inyecciones Intramusculares , Inyecciones Subcutáneas , Praziquantel/uso terapéuticoRESUMEN
Concentrations of copper in livers from red deer (Cervus elaphus) or wapiti (C canadensis) were measured and classified according to the age and species of the animals whether farmed or feral, the area from which they came and their sex. Significant variations occurred with age, species, environment (farmed or feral) and area. Mean liver copper concentrations (after logarithmic transformation) ranged from 356 mg/kg of fresh matter in fetus/neonate to 10.5 mg/kg in mature animals.
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Cobre/análisis , Ciervos/metabolismo , Hígado/análisis , Animales , Femenino , Masculino , Nueva ZelandaRESUMEN
Tablets of micronised nitroscanate (nominal particle size 2--3 microns) were given to a total of 190 dogs that had been experimentally infected with either Echinococcus granulosus or Taenia hydatigena. The efficiency of the drug in tablet form in freeing dogs from tapeworms, was investigated. The dose rate at which 50 per cent of normally fed dogs can be expected to be freed from E granulosus was found to be 89 mg/kg (95 per cent confidence limits 55 mg/kg to 140 mg/kg). The 90 per cent effective dose rate was not determined within the range 32 mg/kg to 250 mg/kg. The dose rate at which 90 per cent of normally fed dogs can be expected to be freed from T hydatigena was 37 mg/kg (95 per cent confidence limits 23 mg/kg to 60 mg/kg).
Asunto(s)
Anticestodos/administración & dosificación , Enfermedades de los Perros/tratamiento farmacológico , Equinococosis/veterinaria , Éteres Fenílicos/administración & dosificación , Teniasis/veterinaria , Tiocianatos/administración & dosificación , Animales , Anticestodos/uso terapéutico , Perros , Equinococosis/tratamiento farmacológico , Éteres Fenílicos/uso terapéutico , Comprimidos , Teniasis/tratamiento farmacológico , Tiocianatos/uso terapéuticoRESUMEN
Trials with oxfendazole carried out on 120 dogs infected with either Echinococcus granulosus or Taenia hydatigena indicated that a single treatment significantly reduced the proportion of dogs infected with tapeworms. Diarrhoea occurred occasionally when the dose rate exceeded 20 mg/kg.
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Antihelmínticos/uso terapéutico , Bencimidazoles/uso terapéutico , Carbamatos/uso terapéutico , Enfermedades de los Perros/tratamiento farmacológico , Equinococosis/veterinaria , Teniasis/veterinaria , Animales , Perros , Equinococosis/tratamiento farmacológico , Teniasis/tratamiento farmacológicoRESUMEN
A limited, but controlled trial with mebendazole incorporated in a prepared food and with tablets given with this food showed that with the former there was an overall reduction in the expected dog population harbouring Echinococcus granulosus and Taenia hydatigena. Neither treatment was fully effective.
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Alimentación Animal , Bencimidazoles/administración & dosificación , Enfermedades de los Perros/tratamiento farmacológico , Equinococosis/veterinaria , Mebendazol/administración & dosificación , Teniasis/veterinaria , Administración Oral , Animales , Perros , Equinococosis/tratamiento farmacológico , Femenino , Masculino , Mebendazol/uso terapéutico , Teniasis/tratamiento farmacológicoRESUMEN
The effect of an antibiotic of the streptothricin class on Echinococcus granulosus and Taenia hydatigena infections has been investigated in a trial involving 160 dogs. The drug showed significant activity in freeing dogs from Thydatigena, but the evidence for similar activity against E granulosus was less well marked. Vomiting and diarrhoea were common sequelae of dosing. The preparation tested consisted of four chemical components and the cestocidal value of each was not determined.