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1.
Zool Stud ; 54: e4, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-31966091

RESUMEN

BACKGROUND: Urbanization is one of the leading causes of habitat loss, habitat degradation, and fragmentation. Urban development negatively affects biodiversity. We clarified changes in butterfly communities due to urbanization in urban green areas. RESULTS: Intotal, 59 species and 1,465 individuals of butterflies were observed in the four urban green areas -Namsan Park(NS), Ewha Womans University (EW), Bukseoul Dream Forest (BD), and Hongneung Forest (HF) -anda natural forest, Gwangneung Forest (GF). The categories of land use around the study sites were determined based on GIS data. Species richness and density of niche breadth and habitat type in the four urban green areas differed mostly from those in GF. Estimated species richness and species diversity (H')in the four urban green areas were significantly lower than those in GF. Species richness and density of forest interior species and specialist species were positively correlated with paddy, field, and forest, whereas those of forest interior species and specialists were negatively correlated with urban area and road. Species composition and community structure of butterflies in the four urban were differed from those in GF. CONCLUSIONS: Theseresults suggest that decreases in paddy, field, and forest associated with the increased urban area and road negatively influenced species composition and changed butterfly communities.

2.
J Control Release ; 160(2): 194-9, 2012 Jun 10.
Artículo en Inglés | MEDLINE | ID: mdl-22094102

RESUMEN

Tumor necrosis factor-alpha (TNFα) is a classic proinflammatory cytokine implicated in the pathogenesis of several autoimmune and inflammatory diseases including viral encephalitis. Macrophages being major producers of TNFα are thus attractive targets for in vivo RNA interference (RNAi) mediated down regulation of TNFα. The application of RNAi technology to in vivo models however presents obstacles, including rapid degradation of RNA duplexes in plasma, insufficient delivery to the target cell population and toxicity associated with intravenous administration of synthetic RNAs and carrier compounds. We exploited the phagocytic ability of macrophages for delivery of Dicer-substrate small interfering RNAs (DsiRNAs) targeting TNFα (DsiTNFα) by intraperitoneal administration of lipid-DsiRNA complexes that were efficiently taken up by peritoneal macrophages and other phagocytic cells. We report that DsiTNFα-lipid complexes delivered intraperitoneally altered the disease outcome in an acute sepsis model. Down-regulation of TNFα in peritoneal CD11b+ monocytes reduced liver damage in C57BL/6 mice and significantly delayed acute mortality in mice treated with low dose LPS plus d-galactosamine (D-GalN).


Asunto(s)
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control , ARN Helicasas DEAD-box/metabolismo , Macrófagos/efectos de los fármacos , ARN Interferente Pequeño/administración & dosificación , Ribonucleasa III/metabolismo , Factor de Necrosis Tumoral alfa/antagonistas & inhibidores , Animales , Antígeno CD11b/metabolismo , Técnicas de Cultivo de Célula , Línea Celular , Enfermedad Hepática Inducida por Sustancias y Drogas/epidemiología , Enfermedad Hepática Inducida por Sustancias y Drogas/genética , Enfermedad Hepática Inducida por Sustancias y Drogas/inmunología , Modelos Animales de Enfermedad , Regulación hacia Abajo , Citometría de Flujo , Galactosamina/farmacología , Inyecciones Intraperitoneales , Lipopolisacáridos/farmacología , Liposomas , Macrófagos/inmunología , Macrófagos/metabolismo , Ratones , Ratones Endogámicos C57BL , Monocitos/efectos de los fármacos , Monocitos/inmunología , ARN Interferente Pequeño/genética , Sepsis/inducido químicamente , Sepsis/complicaciones , Sepsis/inmunología , Transfección , Factor de Necrosis Tumoral alfa/genética
3.
Nanotechnology ; 19(30): 305704, 2008 Jul 30.
Artículo en Inglés | MEDLINE | ID: mdl-21828771

RESUMEN

A self-assembled monolayer of Pt nanoparticles (NPs) was studied as a charge trapping layer for non-volatile memory (NVM) applications. Pt NPs with a narrow size distribution (diameter ∼4 nm) were synthesized via an alcohol reduction method. The monolayer of these Pt NPs was immobilized on a SiO(2) substrate using poly(4-vinylpyridine) (P4VP) as a surface modifier. A metal-oxide-semiconductor (MOS) type memory device with Pt NPs exhibits a relatively large memory window of 5.8 V under ± 7 V for program/erase voltage. These results indicate that the self-assembled Pt NPs can be utilized for NVM devices.

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