Asunto(s)
Esclerosis Múltiple/complicaciones , Enfermedades Cutáneas Vesiculoampollosas/complicaciones , Adulto , Antiinflamatorios no Esteroideos/uso terapéutico , Dapsona/uso terapéutico , Femenino , Humanos , Piel/efectos de los fármacos , Piel/patología , Enfermedades Cutáneas Vesiculoampollosas/tratamiento farmacológico , Enfermedades Cutáneas Vesiculoampollosas/patologíaRESUMEN
A 59-year-old Caucasian man suffered from persistent disseminated necrolytic skin lesions for 8 months. They failed to respond to a variety of therapeutic regimens but then cleared spontaneously within a few days. After one week an invasive squamous cell carcinoma of the hypopharynx became clinically apparent. At autopsy, the expected glucagonoma often associated with necrolytic migratory erythema was not found.
Asunto(s)
Carcinoma de Células Escamosas/patología , Epidermólisis Ampollosa/patología , Neoplasias Hipofaríngeas/patología , Síndromes Paraneoplásicos/patología , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad , Piel/patologíaRESUMEN
A 43-year-old white man and his 12-year-old daughter both displayed congenital lower lip pits. Since Van der Woude's description of this syndrome more than forty years ago, little attention has been given to this uncommon anomaly, probably due to variable expressivity, incomplete penetrance, and recognition of its clinical stigmata. We describe two family members with Van der Woude's syndrome and review its clinical aspects, differential diagnosis, and treatment.
Asunto(s)
Labio/anomalías , Adulto , Niño , Labio Leporino/complicaciones , Diagnóstico Diferencial , Femenino , Humanos , Labio/cirugía , Masculino , SíndromeAsunto(s)
Coristoma/complicaciones , Cilios , Dermatitis Atópica/complicaciones , Anomalías Cutáneas/patología , Niño , Femenino , HumanosRESUMEN
A 35-year-old male suffered from an extremely painful embolia cutis medicamentosa. The atypical segmental localization first led to the diagnosis of herpes zoster and an antiviral therapy. Regarding the unusual course of the complication following an intramuscular injection in this case, the question for the real pathomechanisms still remains.
Asunto(s)
Erupciones por Medicamentos/etiología , Inyecciones Intramusculares/efectos adversos , Dolor de la Región Lumbar/tratamiento farmacológico , Piel/irrigación sanguínea , Trombosis/inducido químicamente , Adulto , Erupciones por Medicamentos/diagnóstico , Erupciones por Medicamentos/patología , Herpes Zóster/diagnóstico , Humanos , Masculino , Microcirculación/patología , Necrosis , Piel/patología , Trombosis/diagnóstico , Trombosis/patologíaRESUMEN
A 35-year-old man presented with a painful skin necrosis after a deep ventrogluteal injection of diclofenac and dexamethasone for treatment of severe back pain. Immediately after the injection, the patient felt a strong pain just above the injection site. In the following days a remarkable necrosis developed in the upper gluteal region. Topical therapy with antiseptics and a topical corticosteroid cream plus analgesia with tramadole revealed no improvement of the symptoms. We excised the necrotic area. Within 1 day, the patient was without pain.
Asunto(s)
Erupciones por Medicamentos/etiología , Embolia/etiología , Inyecciones Intramusculares/efectos adversos , Adulto , Dexametasona/administración & dosificación , Dexametasona/efectos adversos , Diclofenaco/administración & dosificación , Diclofenaco/efectos adversos , Erupciones por Medicamentos/patología , Embolia/patología , Humanos , Masculino , Necrosis , Piel/irrigación sanguínea , Piel/patologíaRESUMEN
With a prevalence of 1 to 2% among males of reproductive age, erectile dysfunction is relatively common. For the patient and his partner, erectile disorders may represent a highly stressful situation. Frequently, a number of overlapping causes may be found to be responsible, with a psychological component--which may also arise secondarily--being involved in nearly every form of erectile dysfunction. Possible causes, the diagnostic approach and therapeutic options are discussed.
Asunto(s)
Disfunción Eréctil/etiología , Enfermedades del Pene/diagnóstico , Erección Peniana , Disfunción Eréctil/fisiopatología , Disfunción Eréctil/terapia , Humanos , Masculino , Enfermedades del Pene/fisiopatología , Enfermedades del Pene/terapia , Erección Peniana/fisiologíaAsunto(s)
Erupciones por Medicamentos/diagnóstico , Amoxicilina/efectos adversos , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/etiología , Dermatitis Alérgica por Contacto/patología , Erupciones por Medicamentos/etiología , Erupciones por Medicamentos/patología , Humanos , Masculino , Persona de Mediana Edad , Pruebas del Parche , Penicilinas/efectos adversos , SíndromeRESUMEN
We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression. During this therapy he subsequently developed the following cutaneous neoplasms: squamous cell carcinomas, basal cell carcinomas, Bowen's disease, actinic keratosis, sebaceous hyperplasia, a dysplastic naevus and, finally a nodular malignant melanoma. Adverse effects of the cyclosporin A therapy are discussed, with special reference to dermatologic effects and the implications for patient and doctor.