Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 11 de 11
Filtrar
1.
J Clin Med ; 12(18)2023 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-37762930

RESUMEN

PURPOSE: The treatment of high-grade brain AVMs is challenging and has no guidelines available to date. This study was aimed at reporting the experience of two centers in treating these AVMs through a multi-stage approach consisting of preoperative embolization and microsurgical resection. METHODS: A retrospective review was performed for 250 consecutive patients with a diagnosis of high-grade brain AVM (Spetzler-Martin grades III, IV, and V) treated in two centers in Germany between January 1989 and February 2023. The analyzed data included demographic, clinical, morphological, and neurological data. RESULTS: A total of 150 cases (60%) were classified as Spetzler-Martin grade III, 82 cases (32.8%) were classified as grade IV, and 18 cases (7.2%) were classified as grade V. Eighty-seven cases (34.8%) presented with hemorrhage. The devascularization percentages achieved were <50% in 24 (9.6%), 50-80% in 55 (22%), and >80% in 171 (68.4%) cases. The average number of sessions was 5.65 ± 5.50 and 1.11 ± 0.32 endovascular and surgical procedures, respectively, and did not significantly differ by rupture status. Death or dependency (mRS score ≥ 3) after the last follow-up was observed in 18.8% of patients and was significantly associated with age > 80 years and poor baseline neurological condition. The complete resection rate was 82.3% and was significantly associated with age > 80 years, large nidus, and deep venous drainage. Permanent disabling neurological deficit after at least 3 months of follow-up was diagnosed in 13.2% of patients and was significantly associated with age > 80 years and infratentorial locations. CONCLUSION: A multi-stage treatment for high-grade AVMs is feasible for selected cases but comes at a functional cost. The devascularization percentage was not associated with the investigated outcomes. Age > 80 years was associated with poor safety and effectiveness outcomes; consequently, this treatment should be offered only in exceptional circumstances.

2.
Neurosurgery ; 62(6 Suppl 3): 1532-7, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-18695570

RESUMEN

OBJECTIVE: Evaluation of the safety and effectiveness of endovascular retreatment of intracranial aneurysms with detachable coils. METHODS: Retrospective analysis of clinical outcome as well as angiographic studies both before and after coil retreatment. The indication for retreatment was based on either inadequate occlusion after previous treatment or recurrent perfusion of the aneurysm. RESULTS: A total of 2759 intracranial aneurysms in 2360 patients were treated by endovascular coil occlusion. Of those, 350 (12.3%) aneurysms underwent a second treatment, and 94 (3.4%) aneurysms underwent three or more treatment sessions. The second treatment sessions were performed an average of 27.2 months after the previous procedure. The third and following treatment sessions were conducted an average of 25.3 months after the previous procedure. Initial treatment resulted in 100% occlusion in 63.7% of aneurysms. One hundred percent occlusion was achieved in only 46.9% of the second and 35.2% of the third and following sessions. Stent-assisted coil treatment was used in 5.6% of initial, 28.0% of second, and 20.7% of third and following sessions. Initial treatment sessions were uneventful in 83.2% of cases, second sessions in 86.9% of cases, and third and following sessions in 87.6% of cases. The morbidity-mortality rate for 495 retreatment sessions was 2.2% (n = 11). CONCLUSION: The natural course of aneurysm remnants or recurrent aneurysm perfusion after coil treatment is not completely understood. The low risk of bleeding from partially filled aneurysms must be balanced against the procedure-related risks of retreatment. Great caution is recommended for the treatment of asymptomatic recurrent aneurysms.

3.
Neurosurgery ; 61(2): 244-52; discussion 252-4, 2007 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-17762736

RESUMEN

OBJECTIVE: Preoperative embolization in accordance with multimodal therapies for cerebral arteriovenous malformations (AVMs) is generally the first step in treatment and may result in complete obliteration. The Onyx liquid embolic system (Micro Therapeutics, Inc., Irvine, CA) may offer advantages for intranidal targeted embolization and microsurgical resection. We present our experience in the combined treatment of intracranial AVMs using Onyx embolization and neurosurgical resection. METHODS: We treated a total of 47 patients for compact intracranial AVMs that were located in the frontal or frontoparietal area (16 patients); temporal, temporoparietal, or temporo-occipital regions (12 patients); parietal or parieto-occipital areas (8 patients); occipital regions (8 patients); had basal ganglia involvement (2 patients); and was cerebellar (1 patient). The Spetzler-Martin grading scale values were as follows: 25 patients were Grades I or II, 10 patients were Grade III, and 12 patients were Grades IV or V. Twenty-three AVMs were located in eloquent brain regions. RESULTS: After we performed final embolizations, the mean nidus reduction was 84%. Seven patients had new, nondisabling neurological deficits, and four patients had new, disabling neurological deficits after embolization. Periprocedurally, five vessel perforations and four stuck microcatheters were encountered without clinical deficits. In two patients, delayed hemorrhage after embolization occurred with good clinical outcome. We completely resected 46 AVMs; in one patient, we detected an AVM on postoperative angiography. The mean operative time was 4.7 hours, and the mean blood loss was 455 mL. Clinical status worsened postoperatively in 14 patients. Angiographic and clinical follow-up examinations were available for 42 patients (89%); the average follow-up period was 13 months. We found no relapse of arteriovenous shunt. Fourteen patients improved clinically after discharge. Of the 42 patients followed up, 23 individuals had no neurological deficit, 16 had a nondisabling deficit, and three had a disabling deficit. CONCLUSION: Preoperative use of the Onyx liquid embolic system in cerebral AVM treatment allows profound occlusion by targeted embolization and provides a basis for safe neurosurgical resection.


Asunto(s)
Dimetilsulfóxido , Embolización Terapéutica/métodos , Malformaciones Arteriovenosas Intracraneales/cirugía , Malformaciones Arteriovenosas Intracraneales/terapia , Procedimientos Neuroquirúrgicos , Polivinilos , Adolescente , Adulto , Angiografía Cerebral , Niño , Terapia Combinada , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico por imagen , Cuidados Preoperatorios , Resultado del Tratamiento
4.
Neuroradiology ; 49(7): 555-61, 2007 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-17476494

RESUMEN

INTRODUCTION: We report the results of a prospective clinical study using a new self-expanding nitinol stent (Enterprise) designed for the treatment of wide-necked intracranial aneurysms. METHODS: We treated 31 saccular, wide-necked intracranial aneurysms in 30 patients. Ten aneurysms had recanalized after prior endovascular treatment without a stent, and 21 aneurysms had not been treated before. RESULTS: Stent deployment was successful in all procedures. Additional coil embolization was performed in all aneurysms. Initial complete angiographic occlusion was achieved in 6 aneurysms, a neck remnant was left in 18 aneurysms and there were 7 residual aneurysms. Angiographic follow-up examinations of 30 lesions after 6 months demonstrated 15 complete occlusions, 8 neck remnants and 7 residual aneurysms. One patient refused the 6-month angiographic follow-up. Spontaneous occlusion of the aneurysm had occurred in 14 patients, and 6 aneurysms showed recanalization. Four of these residual aneurysms were retreated. At the 6-month follow-up, 29 parent arteries were unaffected, whereas two parent vessels demonstrated minor asymptomatic narrowing at the stent site. Two patients experienced one or more possible or probable device-related serious adverse events during the 6-month follow-up period. There was no procedural morbidity or mortality at 6 months after the procedure. CONCLUSION: The reported results demonstrated the safety and feasibility of the Cordis Neurovascular Enterprise stent in the treatment of wide-necked intracranial aneurysms. Initial clinical and angiographic results are favorable.


Asunto(s)
Aleaciones , Implantación de Prótesis Vascular , Embolización Terapéutica , Aneurisma Intracraneal/diagnóstico por imagen , Aneurisma Intracraneal/terapia , Stents , Adulto , Anciano , Angiografía Cerebral , Diseño de Equipo , Estudios de Factibilidad , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Resultado del Tratamiento
5.
Neurocrit Care ; 5(2): 134-40, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-17099260

RESUMEN

INTRODUCTION: To describe a new device meant for rapid endovascular thrombectomy of intracranial arteries of various sizes and its first clinical use. METHODS: A device with oriented microfilaments was constructed that consists of a core wires compound surrounded by a dense palisade of perpendicular-oriented stiff polyamid microfilaments (phenox clot retriever). The device is introduced into the target vessel through a 0.021- or 0.027-inch microcatheter, deployed distally to the thrombus, and slowly pulled back under continuous aspiration via the guiding catheter. RESULTS: The clinical use of the phenox clot retriever in two successive patients is described. Case 1: In a 78-year-old patient with acute posterior circulation ischemia not eligible for intravenous or intraarterial thrombolysis, endovascular recanalization of the occluded left V4 segment was possible using the phenox clot retriever within a few minutes. Case 2: A 70-year-old patient presented after the sudden onset of a left upper extremity paresis 1 day after abdominal surgery. Angiography revealed a thromboembolic occlusion of two cortical branches of the right middle cerebral artery. The rolandic artery was recanalized by a single passage of the phenox clot retriever, with complete neurological recovery. CONCLUSION: The phenox clot retriever, a flexible microfilament pattern, might be a useful supplement to the repertoire of currently available devices for endovascular intracranial thrombectomy.


Asunto(s)
Arterias , Trombectomía/instrumentación , Procedimientos Quirúrgicos Vasculares/instrumentación , Anciano , Arterias/patología , Arterias/cirugía , Angiografía Cerebral , Humanos , Masculino , Trombectomía/métodos , Terapia Trombolítica , Procedimientos Quirúrgicos Vasculares/métodos
6.
Neuroradiology ; 48(7): 471-8, 2006 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-16758153

RESUMEN

INTRODUCTION: The endovascular treatment of large and broad-necked aneurysms may require the use of a remodelling balloon or a stent system to achieve proper occlusion while maintaining the patency of the parent vessel. With the advent of self-expanding stents that can be delivered through a microcatheter, this kind of treatment has improved and problems with the previously used balloon expandable stents have largely been overcome. However, rigidity, insufficient track-ability, and limited or non-existent retrieve-ability may still restrict the application of self-expanding stents in some situations. METHODS: Recently, a stent system with a new and different design has been introduced. This stent is highly flexible, fully retrievable, and can be delivered through a standard 0.021-inch microcatheter without a wire. We describe the first nine cases of stent-assisted coil occlusion of intracranial aneurysms with the use of this stent system. Between May and June of 2004, nine patients with large or broad-necked aneurysms were treated in two endovascular centres. The anatomy of the aneurysms and parent vessels, technical details of the procedure, performance of the stent system, and follow-up results were evaluated. RESULTS: In all procedures, the SOLO stent could be introduced without difficulty, in one procedure after positioning of a different self-expanding stent system had failed due to vessel tortuosity. Overlapping stents were placed in one patient and stent retrieval or repositioning was successfully performed in two procedures. There was no interference or limitation of subsequent coil occlusion after stenting. With regard to the stent, immediate post-procedure and follow-up angiograms were unremarkable in terms of thromboembolic events and signs of intimal hyperplasia. CONCLUSION: From our experience, we conclude that the SOLO stent shows satisfactory performance overall. Its unique design gives the stent properties that may help overcome some of the difficulties experienced with other self-expanding intracranial stent systems.


Asunto(s)
Angioplastia/instrumentación , Aneurisma Intracraneal/cirugía , Stents , Adulto , Anciano , Remoción de Dispositivos , Diseño de Equipo , Estudios de Seguimiento , Humanos , Aneurisma Intracraneal/diagnóstico por imagen , Persona de Mediana Edad , Radiografía , Resultado del Tratamiento
7.
Neurosurgery ; 58(3): 443-50; discussion 443-50, 2006 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-16528183

RESUMEN

OBJECTIVE: Endovascular coil embolization of saccular intracranial aneurysms is safe and effective, but long-term results are dissatisfying. Reconstructive treatments using stents improve occlusion rate and protect parent vessels. We present data on our experience with a new self-expanding stent manufactured with braided nitinol wires. METHODS: Twenty-five saccular, complex, and broad-necked intracranial aneurysms in 21 patients were treated electively. They were located at the internal carotid artery (10), basilar trunk (5), cavernous carotid artery (4), basilar tip (2), anterior cerebral artery (2), anterior communicating artery (1), and middle cerebral artery (1). Eleven aneurysms exhibited recanalization after primary endovascular treatment without stent. RESULTS: Stent deployment was successful in 24 lesions, and additional coil embolization was performed in 23. No permanent neurological deficits were encountered consequent to endovascular procedure. Complete or partial occlusion immediately after stent deployment was achieved in 19 aneurysms, whereas no immediate coil embolization was chosen in 6 cases. There were two thromboembolic events related to the deployment of the Leo stent, one failure of stent deployment, difficulties in stent positioning in three cases, and one asymptomatic parent artery occlusion after 7 months. Follow-up (available in 18 patients and 21 aneurysms and obtained at 3-12 mo; average, 5 mo) revealed patent stents in the remaining cases. Angiographic recurrences arose in three lesions, which were retreated without complications. CONCLUSION: Primary and recurrence treatment of saccular and broad-necked intracranial aneurysms using the Leo stent is feasible and effective. No permanent neurological deficits were associated with stent placement. Short-term follow-up identified intact parent arteries and stable occlusion rates in the majority of cases.


Asunto(s)
Aleaciones , Procedimientos Quirúrgicos Electivos/instrumentación , Aneurisma Intracraneal/diagnóstico por imagen , Aneurisma Intracraneal/cirugía , Stents , Adulto , Anciano , Procedimientos Quirúrgicos Electivos/métodos , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Radiografía
8.
Neurosurgery ; 58(2): 224-32; discussion 224-32, 2006 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-16462475

RESUMEN

OBJECTIVE: Evaluation of the safety and effectiveness of endovascular retreatment of intracranial aneurysms with detachable coils. METHODS: Retrospective analysis of clinical outcome as well as angiographic studies both before and after coil retreatment. The indication for retreatment was based on either inadequate occlusion after previous treatment or recurrent perfusion of the aneurysm. RESULTS: A total of 2759 intracranial aneurysms in 2360 patients were treated by endovascular coil occlusion. Of those, 350 (12.3%) aneurysms underwent a second treatment, and 94 (3.4%) aneurysms underwent three or more treatment sessions. The second treatment sessions were performed an average of 27.2 months after the previous procedure. The third and following treatment sessions were conducted an average of 25.3 months after the previous procedure. Initial treatment resulted in 100% occlusion in 63.7% of aneurysms. One hundred percent occlusion was achieved in only 46.9% of the second and 35.2% of the third and following sessions. Stent-assisted coil treatment was used in 5.6% of initial, 28.0% of second, and 20.7% of third and following sessions. Initial treatment sessions were uneventful in 83.2% of cases, second sessions in 86.9% of cases, and third and following sessions in 87.6% of cases. The morbidity-mortality rate for 495 retreatment sessions was 2.2% (n = 11). CONCLUSION: The natural course of aneurysm remnants or recurrent aneurysm perfusion after coil treatment is not completely understood. The low risk of bleeding from partially filled aneurysms must be balanced against the procedure-related risks of retreatment. Great caution is recommended for the treatment of asymptomatic recurrent aneurysms.


Asunto(s)
Embolización Terapéutica/efectos adversos , Embolización Terapéutica/instrumentación , Aneurisma Intracraneal/terapia , Femenino , Estudios de Seguimiento , Humanos , Aneurisma Intracraneal/epidemiología , Complicaciones Intraoperatorias/diagnóstico , Complicaciones Intraoperatorias/prevención & control , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Procedimientos Quirúrgicos Vasculares/instrumentación
9.
J Neurosurg ; 103(6): 990-9, 2005 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-16381185

RESUMEN

OBJECT: The aim of this study was to analyze the effect of the endovascular treatment of basilar artery (BA) bifurcation aneurysms and to compare the results with those published by other neuroendovascular teams. METHODS: The authors performed a retrospective analysis of 316 aneurysms of the BA bifurcation that had been treated using endovascular coil occlusion between November 6, 1992, and February 12, 2005. After the initial embolization procedure, a 90 to 100% occlusion rate was achieved in 86% of the aneurysms. No complication was evident in 80% of the lesions, although periprocedural aneurysm rupture (3.2%) and thromboembolic events (12.3%) were the most frequent complications. Clinical outcome according to the Glasgow Outcome Scale (GOS) was a score of 5 or 4 in 77%, 3 in 11%, 2 in 5%, and 1 in 7% of patients. Initial follow-up angiography studies were obtained in 56% of patients at a mean of 19 months posttreatment and demonstrated a 90 to 100% occlusion rate in 70%. No recurrence was seen on 65% of the aneurysms. Coil compaction was evident on 24% of the follow-up angiograms. A second treatment was performed on 48 aneurysms (15%) a mean of 27 months after the first therapeutic session and resulted in 90 to 100% occlusion in 83% of the lesions. Complications were encountered in 19% of the aneurysms. Rupture did not occur during any of the procedures. Clinical outcome was rated as GOS Score 5 or 4 in 83% of the patients and Grade 3 in 17%. During a cumulative clinical follow up of 821 years in 237 patients, 182 patients (81%) were independent (GOS Score 5 or 4), 33 (14%) were dependent (GOS Score 3), eight (3%) were in a vegetative state, and two (1%) had died. Clinical outcome was significantly worse after previous aneurysm rupture and following procedural complications. CONCLUSIONS: These results are within the range of published data for coil treatment of BA tip aneurysms and confirm both the safety and efficacy of this endovascular treatment method.


Asunto(s)
Angiografía Cerebral , Embolización Terapéutica , Aneurisma Intracraneal/diagnóstico por imagen , Aneurisma Intracraneal/terapia , Aneurisma Roto/etiología , Embolización Terapéutica/efectos adversos , Embolización Terapéutica/instrumentación , Embolización Terapéutica/mortalidad , Estudios de Seguimiento , Escala de Coma de Glasgow , Humanos , Aneurisma Intracraneal/fisiopatología , Estado Vegetativo Persistente/etiología , Recurrencia , Retratamiento , Estudios Retrospectivos , Tromboembolia/etiología , Resultado del Tratamiento
10.
Neurosurgery ; 55(3): 631-8; discussion 638-9, 2004 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-15335430

RESUMEN

OBJECTIVE: Treatment of 11 patients with aneurysms or arteriovenous fistulae of the craniocervical arteries with stent grafts. METHODS: Peripheral stent grafts were deployed in two extracranial internal carotid arteries. Coronary stent grafts were used to treat two giant aneurysms, five direct carotid-cavernous fistulae, one vertebrojugular fistula, and two dissecting aneurysms of the vertebral artery (V2 and V4). RESULTS: Stent grafts were used successfully in two extracranial internal carotid and two extracranial vertebral arteries, one dissecting aneurysm of the intracranial vertebral artery, one giant aneurysm and one pseudoaneurysm of the cavernous internal carotid artery, and five direct carotid-cavernous sinus fistulae. Angiographic follow-up examinations (available in nine patients; obtained at 3 mo to 5 yr; average, 24 mo) revealed normal vessel caliber, and the stent grafts in all 9 of 11 initial patients were patent. There was a recurrent saccular aneurysm adjacent to the stent graft in the patient with the intracranial vertebral artery aneurysm. The following five complications were encountered: transient hemiparesis (n = 2), increased hemiparesis, postprocedural management-related fatality, and ICA dissection. In six patients, stent graft deployment was accomplished without any technical or clinical complication. There were no permanent neurological deficits consequent to stent graft placement. CONCLUSION: Stent grafts are a useful tool for the endovascular treatment of head and neck aneurysms and direct arteriovenous fistulae in selected patients. The major disadvantage of the currently available stent grafts is their lack of mechanical flexibility. Maneuvering stent grafts in the intracranial arteries carries the risk of iatrogenic vessel dissection and may require supportive measures and protection of the target site by conventional stents.


Asunto(s)
Angioplastia de Balón , Disección Aórtica/terapia , Fístula Arteriovenosa/terapia , Prótesis Vascular , Aneurisma Intracraneal/terapia , Stents , Adulto , Anciano , Disección Aórtica/diagnóstico por imagen , Angiografía de Substracción Digital , Fístula Arteriovenosa/diagnóstico por imagen , Encéfalo/irrigación sanguínea , Arteria Carótida Interna/diagnóstico por imagen , Fístula del Seno Cavernoso de la Carótida/diagnóstico por imagen , Fístula del Seno Cavernoso de la Carótida/terapia , Angiografía Cerebral , Niño , Femenino , Estudios de Seguimiento , Humanos , Aneurisma Intracraneal/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Examen Neurológico , Evaluación de Procesos y Resultados en Atención de Salud , Factores de Riesgo , Disección de la Arteria Vertebral/diagnóstico por imagen , Disección de la Arteria Vertebral/terapia
11.
Herz ; 28(6): 521-9, 2003 Sep.
Artículo en Alemán | MEDLINE | ID: mdl-14569393

RESUMEN

Recent technical advances in both multislice spiral computed tomography (MSCT) and electron-beam computed tomography (EBT) renewed the clinicians' interest in the potentials of CT-based, contrast-enhanced, noninvasive coronary angiography. Despite the fact that invasive, selective coronary angiography remains the "gold standard", cardiac CT lumenography permits visualization of flow-limiting coronary stenosis with a sensitivity and specificity of about 90%. The method is, nevertheless, limited by imaging artifacts which are due to extensive coronary calcifications, or, especially in the right coronary and circumflex artery, to rapid coronary motion. Moreover, the clinical value for the exclusion of obstructive coronary artery disease is not yet established, and further prospective studies are required. On the other hand, cardiac CT permits reliable estimation of coronary calcification and quantification of overall coronary plaque burden and thereby allows risk assessment to predict the individual cardiovascular risk. Diagnostic accuracy may be enhanced by combining assessment of calcified plaque burden and contrast imaging. The newer MSCT technology also allows for differentiation of coronary lesion configuration, especially of noncalcified plaques. However, very few data are currently available on this aspect, and the future clinical relevance of this promising technique remains to be proven. The purpose of this article is to describe the principles and potentials of contrast-enhanced coronary CT imaging and to summarize the practical limitations with the currently available scanning equipment.


Asunto(s)
Angiografía Coronaria/métodos , Enfermedad de la Arteria Coronaria/diagnóstico por imagen , Enfermedad de la Arteria Coronaria/patología , Tomografía Computarizada Espiral , Tomografía Computarizada por Rayos X , Medios de Contraste , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Selección de Paciente , Factores de Riesgo , Ultrasonografía Intervencional
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA