RESUMEN
INTRODUCTION: Typhi is one of the rickettsial species endemic in the Mediterranean countries and is associated with the zoonotic infection of murine typhus, which may have a complicated course especially in adult patients. The association with macrophage activation syndrome (MAS) has rarely been reported in the medical literature. CASE REPORT: We describe a case of murine typhus in a diabetic woman complicated with MAS, who was effectively treated with cyclin and parenteral immunoglobulin. CONCLUSION: The murine typhus can be exceptionally complicated with SAM. This infection should be suspected in front of the discovery of SAM.
Asunto(s)
Activación de Macrófagos , Tifus Endémico Transmitido por Pulgas/complicaciones , Corticoesteroides/uso terapéutico , Anemia/etiología , Anemia/terapia , Anticuerpos Antibacterianos/sangre , Transfusión de Componentes Sanguíneos , Diabetes Mellitus Tipo 2/complicaciones , Doxiciclina/uso terapéutico , Quimioterapia Combinada , Exantema/etiología , Femenino , Fiebre/etiología , Humanos , Inmunoglobulinas Intravenosas/uso terapéutico , Persona de Mediana Edad , Retinitis/etiología , Rickettsia typhi/inmunología , Síndrome , Trombocitopenia/etiología , Trombocitopenia/terapia , Tifus Endémico Transmitido por Pulgas/diagnóstico , Tifus Endémico Transmitido por Pulgas/tratamiento farmacológico , Tifus Endémico Transmitido por Pulgas/inmunología , Tifus Endémico Transmitido por Pulgas/microbiologíaRESUMEN
Gougerot Sjögren syndrome is rare during childhood. Diagnosis in adult patients is usually based on sets of criteria combining clinical, serological, and salivary gland histopathological findings. In the pediatric age group, clinical manifestations might be different from the adult form. We report on 3 cases of childhood Gougerot Sjögren syndrome.