Encapsulation of cinnamon oil in whey protein counteracts the disturbances in biochemical parameters, gene expression, and histological picture of the liver and pancreas of diabetic rats.

This study aimed to evaluate the protective role of encapsulated cinnamon oil emulsion (COE) in whey protein concentrate (WPC) against the disturbance in lipid profile, oxidative stress markers, and gene expression in streptozotocin (STZ)-treated rats. COE was analyzed using GC-MS, and the emulsion was prepared and characterized. In the in vivo study, six groups of male rats were treated orally for 4 weeks, including the control group, the group treated with STZ (D-rats), the groups received a low or high dose of COE (200 or 400 mg/kg B.w.), and the D-rats groups received COE at the low or high dose. Blood and tissue samples were collected after the end of the treatment period for biochemical, genetical, and histological analyses. The GC-MS results revealed that the major components of the oil were cinnamaldehyde, 1,8 cineole, acetic acid, 1,7,7-trimethylbicyclo[2.2.1]hept2yl ester, α-Pinene, and α-Terpineol. The size, zeta potential, and polydispersity index (PDI) of COE were 240 ± 1.03 nm, - 7.09 ± 0.42, and 0.36, respectively. The in vivo results revealed that COE at the two tested doses improved the levels of glucose, insulin, amylase, lipid profile, hepatic MDA, SOD, and GSH. COE also downregulated hepatic GLU2, FAS, SREBP-1c, and PEPCK gene expression and upregulated IGF-1 mRNA expression in diabetic rats in a dose-dependent manner. Moreover, COE improved and the histological picture of the liver and pancreas. It could be concluded that COE overcomes the disturbances in biochemical, cytological, and histopathological changes in D-rats via the enhancement of antioxidant capacity; reduces the oxidative stress; modulates the concerned gene expression; and may be promising to develop new drugs for diabetic treatment.

The Outcome of Multidisciplinary Management of Carotid Body Tumors: Retrospective Cohort Study.

BACKGROUND: Carotid body tumor (CBT) is a rare paraganglionic hyper-vascular tumor of the carotid body. The standard treatment for CBTs is surgery, but it involves risk. The study is aimed to assess the CBTs and evaluate the outcome of multidisciplinary management. MATERIALS AND METHODS: A retrospective cohort study included patients with CBTs who were managed by surgical excision between May 2006 and April 2018. A multidisciplinary team was established to excise the tumor completely with minimal neurovascular compromise. RESULTS: The study comprised of 32 patients in the age group of 23-65 years. The main presentation was a unilateral painless neck mass. Six cases (18.75%) were Shamblin I, 10 (31.25%) Shamblin II and 16 (50%) Shamblin III. Complete excision was performed for all cases. Ligation of the external carotid artery was done in 15 cases (46.88%) and repair of the internal carotid artery in 6 (18.75%). Postoperative cranial nerve complications occurred in six patients (18.75%): four transient hypoglossal pareses and two hoarseness of voice. Histopathologically, one case (3.125%) was malignant. No recurrence was detected through the follow-up period. CONCLUSION: A multidisciplinary approach is essential for management of CBTs. Early diagnosis and surgical resection minimize morbidity and carry good surgical outcome. TRIAL REGISTRATION NUMBER: ChiCTR1800018722 (Agency: Chinese Clinical Trial Registry).

Rupture vesicale du post partum; a propos d'un cas

La rupture secondaire vesicale intra peritoneal du post partum est rare. Nous rapportons une observation inhabituelle chez une femme de 25 ans qui etait adressee pour douleur abdominale aigue. Cinq jours auparavant; elle presentait un accouchement dystocique d'une grossesse menee a terme. Elle presentait une occlusion intestinale aigue du grele mecanique. L'abord median sus et sous ombilical permettait d'objectiver une rupture vesicale intra peritoneale et de traiter la lesion par suture en deux plans sous couvert d'une sonde uretro vesicale. La lesion vesicale etait parvenue au cours d'un accouchement dystocique sur vessie pleine. Une verification systematique du bas appareil urinaire apres toute intervention obstetricale laborieuse permet d'evoquer le diagnostic

Les fractures bilaterales de jambe de l'adulte traitees au Centre Hospitalier Universitaire d'Antananarivo

Objectif : Analyser les aspects epidemiologiques; diagnostiques; anatomopathologiques et therapeutiques des fractures bilaterales de jambe chez l'adulte au Centre Hospitalier Universitaire d'Antananarivo et d'en evaluer les resultats de leur prise en charge. Patients et methodes : Il s'agit d'une etude retrospective; sur une periode de 3 ans; colligeant 12 cas de fracture bilaterale de jambe; traites et suivis pendant au moins 6 mois. L'age; le sexe; les circonstances de l'accident; les types anatomo-pathologiques des lesions selon la classification de Gustilo et de Winquist; la conduite therapeutique ainsi que les resultats obtenus sont analyses. Resultats : Neuf cas de fractures de type I; 7 cas de type II; 4 cas de type III et 4 cas de type IV de Winquist etaient enregistres. Quatorze fractures etaient ouvertes chez 11 patients. Une amputation bilaterale de jambe etait realisee en urgence dans 1 cas. Le traitement orthopedique etait realise dans 1 cas. Dix patients avaient beneficie d'une osteosynthese en un seul temps operatoire. L'enclouage centromedullaire bilateral etait la methode de traitement dans la moitie des cas. Un cas d'osteite tibiale sur plaque vissee etait observe. Nos resultats anatomiques et fonctionnels sont juges satisfaisants malgre nos moyens techniques limites. Conclusion : Les fractures bilaterales de jambe sont relativement rares; le plus souvent observees dans le cadre d'un polytraumatisme. L'osteosynthese en un seul temps et en differee; quel que soit l'etat cutane est notre strategie therapeutique. L'enclouage centromedullaire; a foyer ouvert reste une alternative efficace dans notre serie

Early diagnosis of colorectal cancer: a preventive task in occupational health.

Morbidity of colorectal cancer is still accreting; therefore in 2003 a total of 57000 patients fell ill and about 28000 died due to colorectal carcinoma. According to the etiology, many different factors are currently in discussion. However, as in about 25-30% of the cases familial clustering can be observed one of the most probable might be the genetic predisposition. Nevertheless only in 3% of all cases this predisposition is also scientifically assured. The high average age of manifestation raised the question if there might be also an occupational relationship for colorectal carcinoma in tense of an occupational disease. Therefore there is sight for occupational health to contribute to early diagnosis of colorectal carcinoma within the scope of routine check-up, health management and research of occupational diseases.

[Iatrogenic lesion of the radial nerve--disability in domestic work concerning liability]. / Iatrogene Radialisschädigung--die konkrete Behinderung der Hausfrau in der Haftpflichtversicherung.

In liability cases caused by accidents, the actual compensation for consecutive sustained damage to the patients' health and pain is not sufficient. Moreover, besides payments for a loss of earning capacity, the compensation for loss of efficiency in daily life such as for domestic work might be necessary. Therefore, distinct indications for the expert's appraisal exist.

Smoking behavior and related factors among Japanese nursing students: a cohort study.

BACKGROUND: Although there have been several surveys on smoking behavior among Japanese nursing students, most have been cross-sectional studies. No longitudinal studies, such as a prospective cohort study, have ever been carried out. We therefore conducted a cohort study on, and analyzed smoking behavior and related factors among, Japanese nursing students. METHODS: A survey on smoking behavior using a confidential questionnaire was conducted on nursing students at two vocational schools of nursing and two nursing colleges/universities located in the Tokyo metropolitan area. Another survey was subsequently conducted in the same manner among the same subjects 1 year later. The surveys were conducted between 1997 and 1999. RESULTS: Over the 1-year period, the prevalence of smoking among nursing students increased by 10% for students at the vocational schools of nursing (n = 224) and by 3% for students at the nursing colleges/universities (n = 222). The average score for nicotine dependence for students who were daily smokers at both time points rose from 3.6 to 4.4 (P < 0.05). Two factors found to significantly predict smoking behavior were having friends who smoke and living alone. CONCLUSION: Smoking prevalence is increasing among Japanese nursing students. Smoking prevention and cessation interventions should be instituted in all nursing training programs.

Spectrum analysis of respiratory sound: application to smokers and non-smokers.

Previous studies have indicated that respiratory sound signals may contain information useful in the detection of lung diseases. In this study, measurement and recordings of respiratory sound signal segments were obtained in normal subjects (non-smokers) and smokers in both inspiration and expiration phases. By using the autoregressive (AR) method, it is possible to produce power spectra of respiratory sound signals in inspiration and expiration phases for smokers and non-smokers of each group. The selection of the AR model order of the respiratory sound signals is achieved using Akaike criterion. The AR model order of 9 is required for completely described respiration sound signal segments in inspiration and expiration phases for both groups. The power spectra in the smoker group show larger distinct peaks at lower frequencies as well as more harmonics in both inspiration and expiration phases compared to the power spectra of the non-smoker group. Another diagnostic indicator was derived from the relative position of poles of the AR model of respiratory sound signals. In all smokers it was found that the first, third and fourth poles were closer to a unit circle than those in non-smokers (P < 0.01). It seems that the use of these indicators may be useful as early diagnostic tool for lung diseases.

Blood superoxide dismutase and plasma malondialdehyde among workers exposed to asbestos.

Blood superoxide dismutase (SOD) and plasma malondialdehyde (MDA) (an indicator of lipid peroxidation [LPO]) were determined in 97 randomly selected asbestos exposed workers (age range: 25-60 years, mean duration of exposures 19.8 +/- 8.3 years) and in 42 healthy male controls. MDA, SOD, and MDA/SOD ratio in asbestos exposed workers were significantly higher than in controls. Among both the controls and exposed workers neither age nor smoking was related to SOD or MDA levels. SOD was significantly positively correlated with MDA among the exposed workers. Such correlation was not observed among the controls. SOD but not MDA was significantly positively correlated with the duration of exposure to asbestos. Mean levels of SOD or MDA in exposed workers with radiographic signs of lung fibrosis or pleural thickening did not differ significantly from those without such signs. The results confirm the possible involvement of LPO and development of anti-oxidant mechanism(s) of prolonged exposure to asbestos in humans. However, SOD seems not to be the essential anti-asbestos-induced LPO. Relation between these factors and lung fibrosis is still unclear.

Blood lead level of Cairo traffic policemen.

Blood lead level, haemoglobin concentration (Hb) and urinary delta-aminolevulenic acid (ALA) were determined for 126 traffic policemen and a control group of 50 office-based policemen of Cairo city. Mean blood lead level and Hb of traffic policemen were significantly higher than those of the controls; ALA of both groups were similar. The blood lead level of traffic policemen was not related to age, duration of employment or Hb. Although the observed blood lead level of Cairo traffic policemen (29.2 +/- 7.5 microns dl-1) may be considered acceptable for their occupation, it indicates a potential risk from traffic-exhaust-induced air pollution for other groups of the Cairo population such as children and pregnant women.

The cardiac ganglia in streptozotocin-induced diabetic rats.

The ultrastructure of the cardiac ganglia of streptozotocin-induced diabetic rats was studied at survival times of 3 and 7 days, 1, 3, 6, 9 and 12 months. At 3-7 days post-induction, some intracardiac neurons showed an overall increase in electron density, with the dendrites darkening first. Some of the affected dendrites appeared jet black and their intracytoplasmic organelles were hardly distinguishable except for some swollen mitochondria. Both electron dense and lucent types of degenerating axon terminals were observed in the interstitial spaces. Several myelinated and unmyelinated axons also showed early signs of degeneration. At 1-6 months post-induction, numerous myelinated and unmyelinated axons were shown to be degenerated. The majority of the intracardiac neurons appeared to be normal. Numerous macrophages containing phagosomes were found in the interstitial spaces. At 9-12 months post-induction, macrophages containing engulfed debris were still commonly observed amongst the neuronal profiles, which appeared to be morphologically normal. It is concluded that degenerative changes occur in the cardiac ganglia of streptozotocin-induced diabetic rats and that these changes appear to be both progressive and prolonged.

Relative cardiac cost and physical, mental and psychological work load among a group of post-operative care personnel.

Continuous registration of heart rate and careful minute-by-minute observation of all physical, mental and psychological job-related events was carried out in a group of nine post-operative care personnel. The relative cardiac cost (RCC) correlated significantly with the observed work events. The magnitude of participation of physical, mental and psychological work elements in the changes in RCC varied in the investigated subjects according to the type and magnitude of the different work events. However, collective data on the group indicated that changes in RCC were related mainly to physical effort and to a lesser, albeit significant, extent to psychological reaction. The results indicate the possibility of using the heart rate in monitoring working conditions and, probably, in guiding their improvement.

Quantitative evaluation of ECG components of workers exposed to carbon disulfide.

The components of electrocardiograms (ECG) of 253 workers exposed to carbon disulfide (CDS) and those of 99 controls were quantitatively measured and evaluated. ECG of the exposed workers showed a statistically significant higher prevalence of ECG pathological changes, higher P amplitude and Macruz index, longer P duration, longer both crude and corrected Q-T intervals and R-R intervals and shorter P-R segments and QRS intervals than that of the controls. On the other hand, P-R intervals and heart rates of the two groups were not significantly different. Among both the the exposed and control groups, values of P duration were significantly negatively correlated with that of P-R segment: r = -0.216 and -0.132, respectively, p greater than 0.05. Values of the ECG components were not related to duration of exposure to CDS. Moreover, no significant difference was observed between duration of exposure of the exposed workers with and of those without pathological ECG changes. The method used in our study may be useful in evaluating the ECG of exposed workers before the appearance of the known pathological abnormalities.

Serum choline esterase and liver function among a group of organophosphorus pesticides sprayers in Egypt.

This study was initiated to investigate the long term effect of exposure to organophosphorus pesticides (O.P), with consideration to bilharziasis (an endemic parasitic disease in Egypt, usually associated with liver fibrosis). Serum levels of choline esterase (Ch E), glutamic pyruvic transaminase (SGPT), alkaline phosphatase (Alk. Ph.) and proteins were estimated among 100 (O.P.) sprayers with various duration of exposure (3 to 15 years) and among 60 controls. O.P. sprayers showed significantly higher, SGPT and Alk. Ph. and lower Ch E and serum proteins than the controls. Among sprayers, duration of exposure to O.P. was significantly correlated with their levels of Ch E, SGPT, and Alk. Ph. but not with serum proteins. Compared to other parameters, SGPT seems to be a good indicator of the hepatic effect of long term exposure to O.P. Bilharzial infection did not modify the effect of O.P. pesticides on the above mentioned parameters. Ch E of smoker sprayers was significantly less than that of non smokers. This was attributed to increased absorbtion of O.P. during smoking at work places.

Plasma lipid peroxides among workers exposed to silica or asbestos dusts.

Plasma malondialdehyde (MDA) (an indicator of lipid peroxidation) was determined in random samples of workers (age range 25-60 years) exposed to silica dust (n = 31, mean exposure duration 21.3 +/- 8.3 years) or asbestos dust (n = 59, mean exposure duration 15.6 +/- 4.5 years) and in 52 age-matched healthy male controls. MDA levels of both exposed groups were significantly higher than that of the controls and were significantly higher among workers exposed to asbestos than among those exposed to silica dusts. Neither age nor smoking was related to MDA levels among both controls and exposed workers; among the latter group MDA was not significantly correlated with duration of exposure. Mean MDA levels of exposed workers with radiographic signs of lung fibrosis or pleural thickening and of those without such signs were not significantly different, except in the case of asbestos-exposed workers where it was significantly less than that of those without such signs. Differences between mean durations of dust exposure of workers with radiographic signs of lung fibrosis and those without such signs were statistically insignificant. The results suggest the possible involvement of lipid peroxidation on exposure to silica or asbestos dusts in humans and possible development of antioxidant mechanism(s) on prolonged dust exposure and support the opinion that development of pneumoconiosis depends on susceptibility factor(s).

Skin photoplethysmography--a review.

The photoplethysmograph has been used for over 50 years but there are still misconceptions in how and what is the information obtained. A photoplethysmograph signal from any site on the skin can be separated into an oscillating (a.c.) and a steady-state (d.c.) component, their amplitudes dependent upon the structure and flow in the vascular bed. Many simple applications are available: pulse counters, using the a.c. component, skin colour and haemoglobin saturation meters, using the d.c. component. The d.c. component of the photoplethysmograph signal is a function of the blood flux beneath the device. A good emitter for use in a photoplethysmograph of skin blood flow is one in the frequency range 600-700 nm and the best signal for a.c. analysis is obtained from the finger pulp. The frequency range of the electronic circuitry should be from 0.01 to 15 Hz, then all the information in the signal can be extracted about the autonomic nervous system control of the cardiovascular system, particularly between 0.01 and 2 Hz. Comparative studies may be drawn between similar skin sites on a subject or between subjects if the afferent inputs to the brain stem are controlled or driven at a known frequency. These afferents, inputs, will modulate the efferents, outputs, which generate variations in the a.c. component of the detected photoplethysmograph signal.

Follow-up of hearing thresholds among forge hammering workers.

Hearing threshold was reexamined in a group of forge hammering workers investigated 8 years ago with consideration of the age effect and of auditory symptoms. Workers were exposed to impact noise that ranged from 112 to 139 dB(A)--at an irregular rate of 20 to 50 drop/minute--and a continuous background noise that ranged from 90 to 94 dB(A). Similar to what was observed 8 years ago, the present permanent threshold shift (PTS) showed a maximum notch at the frequency of 6 kHz and considerable elevations at the frequencies of 0.25-1 kHz. The age-corrected PTS and the postexposure hearing threshold were significantly higher than the corresponding previous values at the frequencies 0.25, 0.5, 1, and 8 kHz only. The rise was more evident at the low than at the high frequencies. Temporary threshold shift (TTS) values were significantly less than those 8 years ago. Contrary to the previous TTS, the present TTS were higher at low than at high frequencies. Although progression of PTS at the frequencies 0.25 and 0.5 kHz was continuous throughout the observed durations of exposure, progression at higher frequencies occurred essentially in the first 10 to 15 years of exposure. Thereafter, it followed a much slower rate. Tinnitus was significantly associated with difficulty in hearing the human voice and with elevation of PTS at all the tested frequencies, while acoustic after-image was significantly associated with increment of PTS at the frequencies 0.25-2 kHz. No relation between PTS and smoking was found. PTS at low frequencies may provide an indication of progression of hearing damage when the sensitivity at 6 and 4 kHz diminishes after prolonged years of exposure. Tinnitus and acoustic after-image are related to the auditory effect of forge hammering noise.

Cytogenetic effects in a group of traffic policemen in Cairo.

The aim of this study was to evaluate the cytogenetic effects in humans exposed to automobile exhaust. The induction of chromosome damage was studied in an exposed group of 28 traffic policemen with exposure of over 10 years and a control group of 15 policemen trainers from the Faculty of Police. The percentage of chromosomal aberrations as well as the mean sister-chromatid exchanges were significantly higher among the traffic policemen than in the control group. The cause for this elevated chromosome damage is most likely due to their exposure to pollutants from automobile exhaust, however, the increase is not correlated with the blood lead level or the duration of employment. On the other hand, the increase in chromosome damage among the traffic policemen is enhanced further by smoking.