[Chronic left ventricular failure of the congestive type in ischemic heart disease]. / Khronicheskaia levozheludochkovaia nedostatochnost' zastoinogo tipa pri ishemicheskoi bolezni serdtsa.

A classification of chronic left ventricular insufficiency of the congestive type associated with coronary heart disease has been elaborated on the basis of the results provided by clinical and hemodynamic studies as well as by the examination of the degree of pulmonary hydration using roentgenologic and radionuclide biindicator methods for evaluating the amount of the extravascular fluid in the lungs. Recommendations are offered as to the treatment of every stage of chronic left ventricular insufficiency.

[Effect of cardiac desympathization, stimulation of the central adrenergic structures and blockade of beta-adrenergic receptors on cardiotonic and cardiotoxic effect of cardiac glycosides]. / Vliianie desimpatizatsii serdtsa, razdrazheniia tsentral'nykh adrenergicheskikh struktur i blokady beta-adrenergicheskikh retseptorov na kardiotonicheskoe i kardiotoksicheskoe deistvie serdechnykh glikozidov.

The object of study were rabbits who had been subjected to ligation of 3 or 4 large branches of the left descending coronary artery 14-20 days before the experiment. In experiments with surgical desympathization of the heart it was established that the inotropic effect of cardiac glycosides did not depend on the concentration of catecholamines in the myocardium. In stimulation of adrenergic structures of the posterior hypothalamus attended with an increase in sympathetic innervation of the cardiovascular system the cardiotoxic threshold of cardiac glycosides was considerably reduced. Propranolol (Inderal) administered in a dose which blocks the beta-adrenergic apparatus of the heart prevents the development of the positive inotropic effect of therapeutic doses of strophanthin K on a hypodynamic left ventricular myocardium.

[Digitalis poisoning, risk factors and digitalis intolerance]. / Digitalisnaia intoksikatsiia, faktory riska i preduprezhdenie digitalisnoi neperenosimosti

It was established by means of radioimmunoassay that the blood concentration of Digoxin in patients with congestive heart failure depends not only on the dose of the drug given, but also on the stage of cardiac insufficiency. With equal daily doses, higher Digoxin concentrations were observed in patients with more severe cardiac insufficiency. The analysis of the obtained data has demonstrated that in 75% of the patients with signs of digitalis intoxication the concentration of Digoxin in blood exceeded 2.5 ng/ml. In animal experiments it was established that a distinct reduction of the toxic threshold took place in rabbits with acute myocardial infarction, acute pulmonary embolism, congestive cardiac failure, this threshold being determined by the amount of intravenously injected Strophantin that causes persistent ventricular tachycardia.