International study of childhood leukemia in residences near electrical transformer rooms.

OBJECTIVES: New epidemiologic approaches are needed to reduce the scientific uncertainty surrounding the association between extremely low frequency magnetic fields (ELF-MF) and childhood leukemia. While most previous studies focused on power lines, the Transformer Exposure study sought to assess this association using a multi-country study of children who had lived in buildings with built-in electrical transformers. ELF-MF in apartments above built-in transformers can be 5 times higher than in other apartments in the same building. This novel study design aimed to maximize the inclusion of highly exposed children while minimising the potential for selection bias. METHODS: We assessed associations between residential proximity to transformers and risk of childhood leukemia using registry based matched case-control data collected in five countries. Exposure was based on the location of the subject's apartment relative to the transformer, coded as high (above or adjacent to transformer), intermediate (same floor as apartments in high category), or unexposed (other apartments). Relative risk (RR) for childhood leukemia was estimated using conditional logistic and mixed logistic regression with a random effect for case-control set. RESULTS: Data pooling across countries yielded 16 intermediate and 3 highly exposed cases. RRs were 1.0 (95% CI: 0.5, 1.9) for intermediate and 1.1 (95% CI: 0.3, 3.8) for high exposure in the conditional logistic model. In the mixed logistic model, RRs were 1.4 (95% CI: 0.8, 2.5) for intermediate and 1.3 (95% CI: 0.4, 4.4) for high. Data of the most influential country showed RRs of 1.1 (95% CI: 0.5, 2.4) and 1.7 (95% CI: 0.4, 7.2) for intermediate (8 cases) and high (2 cases) exposure. DISCUSSION: Overall, evidence for an elevated risk was weak. However, small numbers and wide confidence intervals preclude strong conclusions and a risk of the magnitude observed in power line studies cannot be excluded.

Health-Economics Analyses Applied to ELF Electric and Magnetic Fields.

Extremely low frequency electric and magnetic fields (ELF EMFs) are a common exposure for modern populations. The prevailing public-health protection paradigm is that quantitative exposure limits are based on the established acute effects, whereas the possible chronic effects are considered too uncertain for quantitative limits, but might justify precautionary measures. The choice of precautionary measures can be informed by a health-economics analysis (HEA). We consider four such analyses of precautionary measures that have been conducted at a national or state level in California, the Netherlands, the United Kingdom, and Israel. We describe the context of each analysis, examine how they deal with some of the more significant issues that arise, and present a comparison of the input parameters and assumptions used. The four HEAs are methodologically similar. The most significant qualitative choices that have to be made are what dose-response relationship to assume, what allowance if any to make for uncertainty, and, for a CBA only, what diseases to consider, and all four analyses made similar choices. These analyses suggest that, on the assumptions made, there are some low-cost measures, such as rephasing, that can be applied to transmission in some circumstances and that can be justifiable in cost-benefit terms, but that higher cost measures, such as undergrounding, become unjustifiable. Of the four HEAs, those in the United Kingdom and Israel were influential in determining the country's EMF policy. In California and Netherlands, the HEA may well have informed the debate, but the policy chosen did not stem directly from the HEA.

Magnetic field measurements near stand-alone transformer stations.

Extremely low-frequency (ELF) magnetic field (MF) measurements around and above three stand-alone 22/0.4-kV transformer stations have been performed. The low-voltage (LV) cables between the transformer and the LV switchgear were found to be the major source of strong ELF MFs of limited spatial extent. The strong fields measured above the transformer stations support the assessment method, to be used in future epidemiological studies, of classifying apartments located right above the transformer stations as highly exposed to MFs. The results of the MF measurements above the ground around the transformer stations provide a basis for the assessment of the option of implementing precautionary procedures.

Supporting non-experts in judging the credibility of risk assessments (CORA).

PURPOSE: One of the crucial communication issues that have to be tackled by risk assessors is how to provide a comprehensible and informative characterization of their findings. The CORA framework (CORA stands for credibility of risk assessment) is designed for helping non-experts in judging the credibility of risk assessments. The CORA framework can be used by (1) stakeholders and policy makers, to make an educated judgment about the credibility of an assessment, and (2) the authors of a risk assessment, to improve the evaluability of their reports. The CORA framework consists of 18 criteria, leading to six main recommendations. The framework's application is not limited to (EMF) risk assessment, for which it was originally developed, but can be used in any area of risk or hazard assessment.

Time dependence of 50 Hz magnetic fields in apartment buildings with indoor transformer stations.

Twenty-four hour measurements of 50 Hz magnetic fields (MFs) in apartment buildings containing transformer stations have been performed. The apartments were classified into four types, according to their location relative to the transformer room. Temporal correlation coefficients between the MF in various apartments, as well as between MF and transformer load curves, were calculated. It was found that, in addition to their high average MF, the apartments located right above the transformer room also exhibit unique temporal correlation properties.

Exposure to 50 Hz magnetic fields in apartment buildings with indoor transformer stations in Israel.

To advance our understanding of an association between exposure to power frequency magnetic fields (MFs) and the risk of childhood leukemia, we should conduct a study that is convincingly free of selection and response bias, with highly accurate exposure assessment and a large number of highly exposed individuals. Previous measurements revealed that MF in apartments located above internal transformer stations (ITSs) are higher than in other apartments in the same building. An international epidemiologic study of childhood leukemia, TransExpo, was designed to take advantage of this scenario. This article presents the results of an exposure assessment study performed in apartment buildings with ITS in Israel. Measurements were performed in 41 apartments within 10 buildings. Average MF at the height of 0.5 m was 0.40 µT in apartments above the ITS and 0.06-0.12 µT in all other apartments. These results confirm that classification of MF exposure based on apartment location is feasible with remarkable specificity (0.98 and 0.96 for cutoff points of 0.2 and 0.4 µT, respectively) and sensitivity (1.00 for both cutoff points). Because the location of an apartment relative to the ITS can be easily determined, an exposure assessment can reliably be performed without obtaining access to residences.

Risk governance for mobile phones, power lines, and other EMF technologies.

Power-frequency electric and magnetic fields (EMFs) have been present in industrialized countries since the late 19th century and a considerable amount of knowledge has been accumulated as to potential health effects. The mainstream scientific view is that even if there is a risk, it is unlikely to be of major public-health significance. EMFs from cellular communications and other radio-frequency technologies have increased rapidly in the last decade. This technology is constantly changing, which makes continued research both more urgent and more challenging. While there are no persuasive data suggesting a health risk, research and particularly exposure assessment is still immature. The principal risk-governance issue with power frequencies is how to respond to weak and uncertain scientific evidence that nonetheless causes public concern. For radio-frequency electromagnetic fields, the issue is how to respond to large potential consequences and large public concern where only limited scientific evidence exists. We survey these issues and identify deficits in risk governance. Deficits in problem framing include both overstatement and understatement of the scientific evidence and of the consequences of taking protective measures, limited ability to detect early warnings of risk, and attempted reassurance that has sometimes been counterproductive. Other deficits relate to the limited public involvement mechanisms, and flaws in the identification and evaluation of tradeoffs in the selection of appropriate management strategies. We conclude that risk management of EMFs has certainly not been perfect, but for power frequencies it has evolved and now displays many successful features. Lessons from the power-frequency experience can benefit risk governance of the radio-frequency EMFs and other emerging technologies.