Enhanced battery capacity and cycle life due to suppressed side reactions on the surface of Ni-rich LiNi0.8Co0.1Mn0.1O2 cathode materials coated with Co3(PO4)2.

This study explores a strategy to mitigate capacity fading in secondary batteries, which is primarily attributed to side reactions caused by residual Li impurities (LiOH or Li2CO3) on the surface of Ni-rich LiNi0.8Co0.1Mn0.1O2 (NCM811) layered cathode materials. By applying a 1.5 wt% Co3(PO4)2 coating, we successfully formed a thin and stable LiF cathode-electrolyte interface (CEI) layer, which resulted in decreased battery resistance and enhanced diffusion of Li+ ions within the electrolyte. This coating significantly improved the interface stability of NCM811, leading to superior battery performance. Specifically, the discharge capacity of uncoated NCM811 was 190 mA h g-1 at a charge of 4.3 V and a rate of 0.1C, whereas the 1.5Co3(PO4)2/NCM811 exhibited an increased capacity of 213 mA h g-1. Furthermore, the Co3(PO4)2 coating effectively reduced the levels of LiOH and Li2CO3 on the NCM811 surface to only 0.1 %, thereby minimizing adverse side reactions with the electrolyte salt (LiPF6), cation mixing between Ni2+ and Li+, and defects at the NCM811 interface. As a result, battery lifespan was significantly extended. This study presents a robust approach for enhancing battery stability and performance by efficiently reducing residual Li+ ions on the surface of NCM811 through strategic Co3(PO4)2 coating.

Ordered and carbon-doped porous polymeric graphitic carbon nitride nanosheets toward enhanced visible light absorption and efficient photocatalytic H2 evolution.

An effective and rational pathway to tune the electronic bandstructure and visible light absorption properties of low-cost organic graphitic carbon nitride (g-C3N4, GCN) photocatalysts is still very challenging. Here, an efficient strategy is validated to tailor the bandstructure of g-C3N4 and C-doping can be regulated by polymerizing melamine with malonic acid, which can greatly extend the photoresponse range to 900 nm. The optimized GCN exhibits an improved photocatalytic hydrogen production rate of 663.6 µmol g-1 h-1 under visible light irradiation and an apparent quantum yield of 11% at 420 nm, which is three times higher than that of traditional bulk g-C3N4. This superior performance is derived from the unique ordered and porous structure of GCN, which effectively improves its light absorption and provides a larger specific surface area. In addition, the introduction of malonic acid into melamine and the subsequent thermal polymerization reaction further optimize the band structure of GCN, extend its light absorption via C-doping, and improve the photoinduced charge separation, resulting in high photocatalytic performance. This strategy provides a novel platform to design highly efficient GCN-based photocatalysts with precisely tunable operation windows and enhanced charge separation.

Bromine Ion-Intercalated Layered Bi2WO6 as an Efficient Catalyst for Advanced Oxidation Processes in Tetracycline Pollutant Degradation Reaction.

The visible-light-driven photocatalytic degradation of pharmaceutical pollutants in aquatic environments is a promising strategy for addressing water pollution problems. This work highlights the use of bromine-ion-doped layered Aurivillius oxide, Bi2WO6, to synergistically optimize the morphology and increase the formation of active sites on the photocatalyst's surface. The layered Bi2WO6 nanoplates were synthesized by a facile hydrothermal reaction in which bromine (Br-) ions were introduced by adding cetyltrimethylammonium bromide (CTAB)/tetrabutylammonium bromide (TBAB)/potassium bromide (KBr). The as-synthesized Bi2WO6 nanoplates displayed higher photocatalytic tetracycline degradation activity (~83.5%) than the Bi2WO6 microspheres (~48.2%), which were obtained without the addition of Br precursors in the reaction medium. The presence of Br- was verified experimentally, and the newly formed Bi2WO6 developed as nanoplates where the adsorbed Br- ions restricted the multilayer stacking. Considering the significant morphology change, increased specific surface area, and enhanced photocatalytic performance, using a synthesis approach mediated by Br- ions to design layered photocatalysts is expected to be a promising system for advancing water remediation.

Hybrid ternary NiCoCu layered double hydroxide electrocatalyst for alkaline hydrogen and oxygen evolution reaction.

This study focuses on the electrochemical properties of layered double hydroxide (LDH), which is a specific structure of NiCoCu LDH, and the active species therein, rather than the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) of ternary NiCoCu LDH materials. Six types of catalysts were synthesized using the reflux condenser method and coated onto a nickel foam support electrode. Compared to bare, binary, and ternary electrocatalysts, the NiCoCu LDH electrocatalyst exhibited higher stability. The double layer capacitance (Cdl) of the NiCoCu LDH (12.3 mF cm-2) is greater than that of the bare and binary electrocatalysts, indicating that the NiCoCu LDH electrocatalyst has a larger electrochemical active surface area. In addition, the NiCoCu LDH electrocatalyst has a lower overpotential of 87 mV and 224 mV for the HER and OER, respectively, indicating its excellent activity with the bare and binary electrocatalysts. Finally, it is demonstrated that the structural characteristics of the NiCoCu LDH contribute to its excellent stability in long-term HER and OER tests.

Graphene-based strontium niobate-zinc oxide heterojunction photocatalyst for effective reduction of hexavalent chromium.

A hydrothermal technique was employed to synthesize a Sr2Nb2O7-rGO-ZnO (SNRZ) ternary nanocatalyst, in which ZnO and Sr2Nb2O7 were deposited on reduced graphene oxide (rGO) sheets. The surface morphologies, optical properties, and chemical states, of the photocatalysts were characterized to understand their properties. The SNRZ ternary photocatalyst was superior over the reduction of Cr (VI) to harmless Cr (III) compared to the efficiencies obtained using bare, binary, and composite catalysts. The effects of various parameters, including the solution pH and weight ratio, on the photocatalytic reduction of Cr (VI) were investigated. The highest photocatalytic reduction performance (97.6%) was achieved at pH 4 and a reaction time of 70 min. Photoluminescence emission measurements were used to confirm efficient charge migration and separation across the SNRZ, which improved the reduction of Cr (VI). A feasible reduction mechanism for the SNRZ photocatalyst is proposed. This study presents an effective, inexpensive, non-toxic, and stable catalyst, for the reduction of Cr (VI) to Cr (III) using SNRZ ternary nanocatalysts.

Recent developments of polysaccharide based superabsorbent nanocomposite for organic dye contamination removal from wastewater - A review.

One of the main problems with water pollution is dye contamination of rivers, industrial effluents, and water sources. It has endangered the world's sources of drinking water. Several remediation strategies have been carefully developed and tested to minimize this ominous picture. Due to their appealing practical and financial benefits, adsorption methods in particular are often listed as one of the most popular solutions to remediate dye-contaminated water. Biopolymer-based hydrogel nanocomposites are a cutting-edge class of materials with a wide range of applications that are effective in removing organic dyes from the environment. Since the incorporation of various materials into hydrogel matrices generated composite materials with distinct characteristics, these unique materials were often alluded to as ideal adsorbents. The fundamental emphasis of the conceptual and critical review of the literature in this research is the significant potential of hydrogel nanocomposites (HNCs) to remediate dye-contaminated water (especially for articles from the previous five years). The review also provides knowledge for the development of biopolymer-based HNCs, prospects, and opportunities for future research. It is also focused on optimum conditions for dye adsorption processes along with their adsorption kinetics and isotherm models. In summary, the information gained in this review research may contribute to a strengthened scientific rationale for the practical and efficient application of these novel adsorbent materials.

Effective Antibacterial/Photocatalytic Activity of ZnO Nanomaterials Synthesized under Low Temperature and Alkaline Conditions.

The purpose of this study was to evaluate the surface properties of ZnO nanomaterials based on their ability to photodegrade methyl blue dye (MB) and to show their antibacterial properties against different types of Gram-positive bacteria (Bacillus manliponensis, Micrococcus luteus, Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli). In this study, ZnO nanomaterials were synthesized rapidly and easily in the presence of 1-4 M NaOH at a low temperature of 40 °C within 4 h. It was found that the ZnO nanomaterials obtained from the 1.0 M (ZnO-1M) and 2.0 M (ZnO-2M) aqueous solutions of NaOH had spherical and needle-shaped forms, respectively. As the concentration of NaOH increased, needle thickness increased and the particles became rod-like. Although the ZnO nanomaterial shapes were different, the bandgap size remained almost unchanged. However, as the NaOH concentration increased, the energy position of the conduction band shifted upward. Photo current curves and photoluminescence intensities suggested that the recombination between photoexcited electrons and holes was low in the ZnO-4M materials prepared in 4.0 M NaOH solution; however, charge transfer was easy. ∙O2- radicals were generated more than ∙OH radicals in ZnO-4M particles, showing stronger antibacterial activity against both Gram-positive and Gram-negative bacteria and stronger decomposition ability on MB dye. The results of this study suggest that on the ZnO nanomaterial surface, ∙O2- radicals generated are more critical for antibacterial activity than particle shape.

Electrochemical Performance of Layer-Structured Ni0.8Co0.1Mn0.1O2 Cathode Active Materials Synthesized by Carbonate Co-Precipitation.

The layered Ni-rich NiCoMn (NCM)-based cathode active material Li[NixCo(1-x)/2Mn(1-x)/2]O2 (x ≥ 0.6) has the advantages of high energy density and price competitiveness over an LiCoO2-based material. Additionally, NCM is beneficial in terms of its increasing reversible discharge capacity with the increase in Ni content; however, stable electrochemical performance has not been readily achieved because of the cation mixing that occurs during its synthesis. In this study, various layer-structured Li1.0[Ni0.8Co0.1Mn0.1]O2 materials were synthesized, and their electrochemical performances were investigated. A NiCoMnCO3 precursor, prepared using carbonate co-precipitation with Li2CO3 as the lithium source and having a sintering temperature of 850 °C, sintering time of 25 h, and metal to Li molar ratio of 1.00-1.05 were found to be the optimal parameters/conditions for the preparation of Li1.0[Ni0.8Co0.1Mn0.1]O2. The material exhibited a discharge capacity of 160 mAhg-1 and capacity recovery rate of 95.56% (from a 5.0-0.1 C-rate).

Locust Bean gum-based hydrogels embedded magnetic iron oxide nanoparticles nanocomposite: Advanced materials for environmental and energy applications.

This paper reports a simple method of designing and synthesizing magnetic iron oxide (IO) integrated locust bean gum-cl-polyacrylonitrile hydrogel nanocomposites (LBG-cl-PAN/IONP) by in situ mineralization of iron ions in a hydrogel matrix. A two-step gel crosslink method followed by co-precipitation method was used to prepare these novel hydrogels embedded with magnetic iron oxide nanoparticles. The LBG-cl-PAN/IONP hydrogel nanocomposite (HNC) were tested in batch adsorption experiments for their ability to remove a cationic dyes, methylene blue (MB) & Methyl violet (MV), from aqueous solution. In order to analyze the LBG-cl-PAN/IONP HNC, FTIR, XRD, XPS, VSM, TEM, and EDX techniques were applied. Numerous operating parameters were studied, including the amount of adsorbent, the contact time, pH, temperature, the dye concentration, and the coexisting ion concentration. According to the Langmuir isotherm model, MB and MV had maximum monolayer adsorptive capacities of 1250 and 1111 mg/g, respectively. LBG-cl-PAN/IONP HNC controlled IONP oxidation as well as sustained adsorptive removal over a wide pH range (7-10). The key mechanism of adsorption consisted of electrostatic interaction and ion exchange. For successful use in successive cycles after regeneration using HNO3 as eluent, the LBG-cl-PAN/IONP HNC can easily be reused. As a material, the LBG-cl-PAN/IONP HNC is a promising sorbent or composite material for removing toxic dyes from water, and therefore can be applied to enhance water and wastewater treatment technology. Additionally, we have briefly evaluated LBG-cl-PAN/IONP HNC for antibacterial and supercapacitor applications. According to our knowledge, this is the first report describing the use of LBG-cl-PAN/IONP HNC multifunctional efficacy as an excellent sorbent, antibacterial and electrochemical supercapacitor applications.

Band structure alignment transitioning strategy for the fabrication of efficient photocatalysts for solar fuel generation and environmental remediation applications.

Indium hydroxide (In(OH)3) and indium oxide (In2O3) have proven to be efficient catalysts for photocatalytic water-splitting reactions to produce hydrogen (H2) and for organic pollutant degradation applications. However, the limited optical absorption features of indium-based nanostructures have restricted their practical applications. In this study, we have successfully designed indium hydroxide- and indium oxide-loaded metal sulfide (cadmium sulfide, CdS) heterostructures as excellent photocatalytic systems for photocatalytic hydrogen evolution and tetracycline hydrochloride pollutant degradation reactions. In this system, In(OH)3 and In2O3 established Type-I and S-scheme heterojunctions, respectively, with CdS, resulting in superior charge separation properties and outstanding photocatalytic activity. Specifically, the rational and appropriate design of the aforementioned indium-based heterostructures promoted the separation of photoexcited charge carriers via Type-I and S-scheme paths. Accordingly, enhanced photocatalytic H2 evolution activities of 9.58 and 14.98 mmol·g-1·h-1 were achieved for CdS-In(OH)3 and CdS-In2O3, respectively. Furthermore, the highest degradation efficiency of CdS-In2O3 was âˆ¼ 90%, which was higher than those of CdS-In(OH)3 (72%) and bare CdS nanorods (51%). Therefore, the results of this study provide an opportunity to enhance the catalytic activities of heterostructured photocatalytic systems by utilizing the strategy of transitioning band structure alignment from the Type-I to the S-scheme.

Synergistic sorption performance of karaya gum crosslink poly(acrylamide-co-acrylonitrile) @ metal nanoparticle for organic pollutants.

In this work, we tailor facile hydrogels nanocomposite (HNC) based on sustainable karaya gum for water treatment. Karaya gum crosslink poly(acrylamide-co-acrylonitrile) @ silver nanoparticle (KG-cl-P(AAm-co-AN)@AgNPs) HNC were made by an aqueous free radical in situ crosslink copolymerization of acrylamide (AAm) and acrylic acid (AA) in aqueous solution of KG-stabilized AgNPs. FTIR, XRD, DTA-TGA, SEM, and TEM were used to characterize HNC. The hydrogels' swelling, diffusion, and network characteristics were investigated. The removal efficiency of HNC was found to be 99% at pH 8 for a crystal violet (CV), dose of 0.02 g after 1 h. Dye adsorption by these hydrogels was also investigated in terms of isotherms, and kinetics. The dye's exceptionally high adsorption capacity on HNC for CV removal is explained by H-bonding interactions, as well as dipole-dipole and electrostatic interactions between anionic adsorbent and cationic dye molecules (Qmax, 1000 mg/g). The HNC can be regenerated with 0.1 M HCl and reused at least 10 times maintaining over 68% dye removal. The loading of AgNPs into the polymeric matrix of KG-cl-P(AAm-co-AN) significantly increases the removal percentage of CV dye from its aqueous solution, according to this study.

Bismuth quantum dots anchored one-dimensional CdS as plasmonic photocatalyst for pharmaceutical tetracycline hydrochloride pollutant degradation.

Earth abundant metal based plasmonic photocatalysis is one of the most proficient approaches to degrade the emergent organic pollutants in contaminated water. Here, we report that using one-dimensional CdS/zero-dimensional Bi quantum dot (QD) heterostructures (1D/0D CdS/Bi HSs) were obtained via a simple solvothermal reaction. The results specified that the Bi QDs were grown onto CdS NRs through the reduction of Bi3+ ions. The Bi modified CdS HSs were employed as a photocatalyst for pharmaceutical pollutant tetracycline degradation and the optimized sample showed the maximum photocatalytic degradation activity of 90% under visible light radiation within 60 min, which is greater than the pure CdS (52%) under identical conditions. Based on the structural characterizations and degradation efficiency, the obtained CdS/Bi is a promising photocatalyst for the treatment of wastewater which contains emerging pollutants such as organic dyes and pharmaceutical antibiotics during the industrial processes. The boosted photocatalytic degradation efficiency is credited to the doped Bi3+ species; surface plasmon resonance effect that raised from metallic Bi QDs and proficient photoinduced charge carriers separation.

CuS/Ag2O nanoparticles on ultrathin g-C3N4 nanosheets to achieve high performance solar hydrogen evolution.

Ternary heterostructures play a crucial role in improving the separation of charge carriers and fast surface reaction kinetics, which in turn helps in understanding the effective photocatalytic water splitting performance. Herein, CuS/Ag2O nanoparticles were presented on a graphitic carbon nitride (g-C3N4) surface to obtain CuS/Ag2O/g-C3N4 material using facile hydrothermal and precipitation methods. Structural and morphological studies confirmed the presence of ternary nanostructures comprising CuS, Ag2O, and g-C3N4 with nanoparticle and nanosheet morphologies. The as-synthesized CuS/Ag2O/g-C3N4 exhibited a remarkable photocatalytic H2 production of 1752 µmol.h-1.g-1cat, which is considerably superior than those of CuS and g-C3N4. The improved H2 production performance which is due to the effective interfacial CuS/Ag2O/g-C3N4 heterojunction interface and superior hole (h+) trapping capability of the CuS at the CuS/Ag2O/g-C3N4 interface. This can efficiently enhance the lifetime of photoexcited charge carriers and enhance the electron density for the production of H2. The optimum CuS/Ag2O/g-C3N4 heterostructure remained stable after 8 successive experimental cycles, although with a slight change in the H2 production rate. Therefore, this study offers a novel approach to exploit the efficacy through the synergetic effect of integrating CuS as the photocatalyst and Ag2O as the visible sensitizer, thus proposing a viable strategy of using earth-abundant material to enhance the conversion of solar energy to fuel.

Synergistic effects of Tin sulfide Nitrogen-doped titania Nanobelt-Modified graphitic carbon nitride nanosheets with outstanding photocatalytic activity.

Designing efficient ternary nanostructures is a feasible approach for energy production under simulated solar irradiation. In this study, excellent photoexcited charge carrier separation and enhanced visible-light response were achieved with nitrogen-doped titania nanobelts (N-TNBs), whose 1D geometry facilitated the fabrication of a heterostructure with SnS2 on the surface of graphitic carbon nitride (g-C3N4). We established the design of SnS2@N-TNB and SnS2@N-TNB/g-C3N4 heterostructures by in situ hydrothermal and ultrasonication processes, and achieved commendable simulated solar light driven photocatalytic H2 generation. UV-vis diffuse reflectance spectroscopy analysis revealed a red shift in the absorption spectra of the SnS2@N-TNB and SnS2@N-TNB/g-C3N4 samples. The H2 produced via SnS2@N-TNB-10/g-C3N4 (6730.8 µmol/g/h) was 2.6 times higher than that produced by SnS2@N-TNB (2515.1 µmol/g/h), and 299 times higher than that produced by N-TNB (22.5 µmol/g/h). The improved photocatalytic H2 production was attributed to the maximum interface contact between SnS2@N-TNB and g-C3N4, and to the improved visible-light absorption and effective charge-carrier separation. Therefore, the present study provides novel insights for combining the advantages of ternary materials to improve the conversion of solar energy to H2 fuel.

Facile synthesis of sphere-like structured ZnIn2S4-rGO-CuInS2 ternary heterojunction catalyst for efficient visible-active photocatalytic hydrogen evolution.

Photocatalysis is a promising approach for generating hydrogen, an eco-friendly and cost-effective fuel. It is hypothesized that the ternary catalyst ZnIn2S4-rGO-CuInS2, prepared by ultrasonication method, should be effective for optimized photocatalytic hydrogen generation in a Na2S/Na2SO3-water mixture. The as-synthesized catalyst was characterized using various surface analytical and optical techniques. Field-emission scanning electron microscopy and high-resolution transmission electron microscopy analyses revealed that marigold-like structured ZnIn2S4 and layer-structured CuInS2 were dispersed on the reduced graphene oxide sheets. The ternary ZnIn2S4-rGO-CuInS2 system showed enhanced photocatalytic H2 production compared to pure ZnIn2S4, CuInS2, ZnIn2S4-rGO, CuInS2-rGO, and ZnIn2S4-CuInS2 catalysts under visible light illumination. The fabricated ZnIn2S4-rGO-CuInS2 catalyst afforded hydrogen generation of 2531 µmol/g after 5 h. The enhanced performance of the ZnIn2S4-rGO-CuInS2 catalyst originates from the synergetic effect with rGO as the electron transfer medium, and is confirmed by photocurrent density and photoluminescence measurements that indicate reduced recombination between the excited electron and hole pairs, and fast electron transfer in the ternary composite. The excellent performance of the ZnIn2S4-rGO-CuInS2 catalyst for up to three consecutive cycles was demonstrated in cyclic stability tests under visible-light illumination.

Implication of biofilms in the sustainability of acid mine drainage and metal dispersion near coal tailings.

In this study, the ecology of biofilms collected from sediments and efflorescent crusts (EFC) along an acid mine drainage (AMD) system was determined using 16S bacterial metagenomics. The dissolution of coal tailing and EFC by bacteria hosted in biofilms was investigated. Results revealed the predominance of acidophilic bacteria such as Acidithiobacillus ferrooxidans, Leptospirilum ferrooxidans, Acidithrix, Leptospirilum sp, Acidimicrobiaceae, Sulfobacillus, Acidiphilium, and Acidithiobacillus sp. in the biofilms, some of which have been reported to oxidize sulfide minerals and contribute to AMD formation. The experimental results further highlighted the ability of the bacteria in biofilms to leach out metals such as Co, Fe, and Zn, while decreasing the pH of the solution. The bioleaching of EFC was very fast, and increased diversity of the bacterial inoculum contributed to accelerating the leaching rate. Compared to abiotic leaching, the dissolution of minerals by acidophilic bacteria increased the percentage of free hydrated metal speciated forms over the inorganic complex speciated forms, suggesting the potential of biofilms to enhance the dispersion of metals in aquatic systems.

Single layered hollow NiO-NiS catalyst with large specific surface area and highly efficient visible-light-driven carbon dioxide conversion.

A sea urchin-shaped, single-layer, and hollow NiO-NiS photocatalyst with a large surface area was designed for carbon dioxide (CO2) conversion in this study. A d-glucose polymeric hollow frame was fabricated using a d-glucose monomer, and NiO particles were stably grown on it using the hydrothermal method to form a hollow NiO surface. The d-glucose frame was removed by heat treatment to create hollowed NiO; hollowed NiO-NiS (h-NiO-NiS) was subsequently obtained through ion exchange between the O ions in NiO and S ions in the sulfur powder. Additionally, we attempted to determine the correlation among the surface area of the h-NiO-NiS catalyst, CO2 gas adsorption capacity, and catalyst performance. The surface area of the h-NiO-NiS catalyst was ten times larger than that of the nanometer-sized NiO-NiS (n-NiO-NiS, 21.2 m2 g-1) catalyst. The CO2 photocatalytic conversion performance of the hollowed catalyst was approximately seven times larger than that of the nanosized catalyst. As the amount of ion-exchanged S increased, methane selectivity increased, and optimal methane production was obtained when the weight ratio of NiO and sulfur powder was 1 : 4. Using temperature-programmed desorption (TPD) analyses of CO2 and H2O, the adsorption of water molecules on the Ni-S surface and that of CO2 gas on the Ni-O surface during CO2 conversion reaction were confirmed. The h-NiO-NiS catalyst facilitated an effective charge separation through a well-developed interfacial transition between the linked NiS and NiO, and resulted in increased CO2 photoreduction performance under sunlight.

Construction of visible-light driven Bi2MoO6-rGO-TiO2 photocatalyst for effective ofloxacin degradation.

Photocatalytic removal is more appropriate for the destruction of organic contaminants. The ternary Bi2MoO6-reduced graphene oxide (rGO)-TiO2 catalyst was synthesized using a simple hydrothermal method, and various surface analytical optical techniques were analyzed. The photocatalytic decomposition efficiency of the Bi2MoO6-rGO-TiO2 composite was 92.3% higher than those of pure and binary photocatalysts. The effects of operational parameters, such as catalyst ratio, catalyst variation, rGO ratio variation, and pH value variation were also analyzed. The as-prepared ternary photocatalyst exhibited low photoluminescence and high photocurrent density, which suppressed photon-induced electron and hole (h+) recombination and effective charge separation. The study demonstrated that rGO has excellent electron transfer performance and enhanced photocatalytic reaction stability. The perfect cycling stability of Bi2MoO6-rGO-TiO2 was retained even after five consecutive cycles on the photocatalytic degradation reaction performance. In this study, we propose a decomposition performance mechanism for ofloxacin degradation that underwent visible-light irradiation.

Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma.

Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose, nanotechnology has revolutionized the field of medicine with versatile potential capabilities for both the diagnosis, as well as the treatment, of retinoblastoma via the targeted and controlled delivery of anticancer drugs via binding to the overexpressed retinoblastoma gene. Nanotechnology has also generated massive advancements in the treatment of retinoblastoma based on the use of surface-tailored multi-functionalized nanocarriers; overexpressed receptor-based nanocarriers ligands (folate, galactose, and hyaluronic acid); lipid-based nanocarriers; and metallic nanocarriers. These nanocarriers seem to benchmark in mitigating a plethora of malignant retinoblastoma via targeted delivery at a specified site, resulting in programmed apoptosis in cancer cells. The effectiveness of these nanoplatforms in diagnosing and treating intraocular cancers such as retinoblastoma has not been properly discussed, despite the increasing significance of nanomedicine in cancer management. This article reviewed the recent milestones and future development areas in the field of intraocular drug delivery and diagnostic platforms focused on nanotechnology.

A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection.

Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation. To synergistically improve the biopharmaceutical parameters of CIP, a hyaluronic acid (FDA approved biocompatible polymer) functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) was designed in the present study. SNEDDS formulations were tested via solubility, droplet size, zeta potential, a polydispersity index, thermodynamic stability, surface morphology, solid-state characterization, drug loading/release, cellular uptake, and biocompatibility. The final (HA-CIP-SNEDDS) formulation exhibited a mean droplet size of 50 nm with the 0.3 poly dispersity index and negative zeta potential (-11.4 mV). HA-based SNEDDS containing CIP showed an improved ability to permeate goat intestinal mucus. After 4 h, CIP-SNEDDS showed a 2-fold and HA-CIP-SNEDDS showed a 4-fold permeation enhancement as compared to the free CIP. Moreover, 80% drug release of HA-CIP-SNEDDS was demonstrated to be superior and sustained for 72 h in comparison to free CIP. However, anti-biofilm activity of HA-CIP-SNEDDS against Salmonella typhi was higher than CIP-SNEDDS and free CIP. HA-CIP-SNEDDS exhibited increased biocompatibility and improved oral pharmacokinetics as compared to free CIP. Taken together, HA-CIP-SNEDDS formulation seems to be a promising agent against Salmonella typhi with a strong targeting potential.