[Pharmacoepidemiological research of COVID-19 in the Russian Federation EGIDA-2020].

AIM: An analysis of coronavirus infection in Russia and evaluation of different AVT regimens effectiveness. MATERIALS AND METHODS: The study involved a retrospective analysis of 1082 patient records with laboratory-confirmed COVID-19 in 17 regions of Russia. The number of men and women was equal, mean age 48.718.1 (median 50). Patients with moderate COVID-19 (85%) versus mild COVID-19 (15%) were characterized by higher age (median 54 vs 21 years; p0.001), higher body mass index (27.8 vs 23.4; p0.001), prevalence of chronic diseases (75.3% vs 8.5%; p0.001), including circulatory system diseases (37.8%). Moderate COVID-19 characterized higher intoxication (10.86.1 vs 4.22.7 days; p0.001) and catarrhal symptoms duration (10.25.4 vs 6.14.1 days; p0.001). RESULTS: During hospitalization 92% of the patients received AVT, 77% antibiotics, and 16% corticosteroids. Umifenovir therapy resulted in a significant reduction of intoxication (8.75.5 vs 11.75.5 days; p0.001) and catarrhal symptoms duration (8.85.1 vs 12.04.9 days; p0.001) compared to the group without AVT. The usage of INF reduced intoxication symptoms compared with the group without AVT (8.97.5 vs 11.75.5; p0.05). Therapy with hydroxychloroquine, imidazolylethanamide pentandioic acid, and lopinavir + ritonavir combination did not affect the course of COVID-19. Most of adverse reactions were related to antibiotics. CONCLUSION: Umifenovir therapy and inclusion of interferon in AVT regimens was associated improvement in the clinical manifestation of the disease among patients.

[Clinical and morphological aspects of shigellosis flexneri in patients with an aggravated premorbid state]. / Kliniko-morfologicheskie osobennosti shigelleza fleksnera u bol'nykh s otiagoshchennym premorbidnym fonom.

The analysis of 10 fatal outcomes in patients with acute shigellosis during the period of 1999-2000 made it possible to find out that most of deceased shigellosis patients belonged to the group inclined to alcohol abuse and having initial alimentary disturbances. In 6 cases of acute shigellosis with fatal outcome the causative agent was S. flexneri 2a, in 2 cases--S. flexneri 3a, in 1--S. flexneri 4b. The main cause of fatal outcomes was accompanying double pneumonia. Lesions of the intestinal tract in deceased shigellosis patients were of destructive character, resulting, in a number of cases, in serous and perforative peritonitis.

[Antibody avidity indices of the saliva and serum antibodies in salmonellosis patients]. / Izuchenie pokazatelei avidnosti antitel sliuny i syvorotochnykh antitel u bol'nykh sal'monellezami.

The avidity characteristics of salivary and serum antibodies have been determined in 179 salmonellosis patients by means of the indirect hemagglutination inhibition test. These investigation have shown that, in contrast to serum antibodies, no changes occur in the avidity of salivary antibodies in the course of the disease. This is due to the fact that secretory antibodies belong to IgA which have no tendency to ripening. The regularities thus established reflect the role of secretory and serum antibodies in the pathogenesis of Salmonella infections.