Obesity contributes to lower urinary system voiding dysfunction in childhood.

BACKGROUND: Obesity continues to be a leading public health concern in the world. AIM: The aim of our study was to investigate the relationship between obesity, lower urinary tract symptoms (LUTS), and voiding dysfunction. METHODS: The study included students aged between 6 and 16 years in Zonguldak. Anthropometric measurements were performed in 404 children using appropriate methods. The body mass index (BMI) of children was calculated. Obesity was defined as a BMI at or above the 95th percentile for age- and sex-specific percentiles of Turkish children. Non-obese children with a BMI below the 85th percentile were defined as the control group. Lower urinary tract voiding dysfunction (LUTVD) was assessed with the dysfunctional voiding and incontinence scoring system (DVISS). RESULTS: Of the children participated in the study, 151 (37.4%) were obese and 253 (62.6%) were at a normal weight. There were no significant differences in gender and mean age between the obese and non-obese children (p = 0.81). Monosymptomatic nocturnal enuresis (MSNE) was present in 43 children (10.6%), daytime symptoms were present in 38 children (9.4%), and voiding dysfunction was present in 34 children (8.4%) in the study. These symptoms were more common in the obese group (p = 0.001, p = 0.001, and p = 0.0001, respectively). In our survey study, we found a serious relationship between both bladder emptying symptoms and storage symptoms and obesity (p = 0.0001). CONCLUSION: Obese children are at increased risk for enuresis and voiding dysfunction. Screening and treating obese children for the respective symptoms are significantly important for their quality of life.

QT interval evaluation associated with the use of hydroxychloroquine with combined use of azithromycin among hospitalised children positive for coronavirus disease 2019.

INTRODUCTION AND AIM: Hydroxychloroquine alone or in combination with azithromycin has been increasingly used for patients with coronavirus disease 2019, in both children and adults. Drugs are generally well tolerated in clinical practice; however, both can cause corrected QT prolongation. We aimed to report our experience of QT interval evaluation associated with the use of hydroxychloroquine with concurrent azithromycin among children testing positive for coronavirus disease 2019. METHODS: Our single-centre; retrospective, study evaluated children with coronavirus disease 2019 disease admitted to the Pediatric Department at Sancaktepe Training and Research Hospital Istanbul, Turkey from 10 March, 2020 to 10 April, 2020. The data including demographics, clinical symptoms, co-morbid diseases, laboratory, radiological findings as well as electrocardiographs of the patients were obtained from our records. Electrocardiograms were evaluated before, one day after and at the termination of the treatment. RESULTS: 21 patients aged 9 to 18 years were evaluated. The median age was 170 months (range 112-214), 51.1% of them were girls and 48.9% were boys. Their laboratory results did not reveal any abnormalities. None of them needed intensive care. We did not detect QT prolongation during or at the termination of the treatment. CONCLUSION: We did not detect QT prolongation during or at the termination of the treatment in our patients due to the fact that they were not severely affected by the disease. Patients were treated in our inpatient clinic and none of them required intensive care. Laboratory results were also insignificant. Furthermore, they did not need other medications.

URINARY STONE RELATED URINARY TRACT INFECTION CAUSED BY RAOULTELLA ORNITHINOLYTICA IN A CHILD: A CASE REPORT.

Raoultella ornithinolytica is one of the three species of Raoultella. The present case report describes a two-year-old child who had complaints of discomfort and fever, and Raoultella ornithinolytica in his urinary culture. Grade-2 hydronephrosis and a 7.5-mm urinary stone were detected in the patient's left ureter. The stone was expelled upon consultation with pediatric urology department. The patient was treated according to culture antibiotic sensitivity report and continued to be followed-up.

A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report.

Pituitary adenomas usually arise from the anterior lobe of the pituitary gland and are manifested with hormonal disorders or mass effect. Mass effect usually occurs in nonfunctional tumors. Pituitary adenomas may be manifested with visual field defects or rarely in the form of total oculomotor palsy. Visual field defect is most frequently in the form of bitemporal hemianopsia and superior temporal defect. Sudden loss of vision, papilledema and ophthalmoplegia may be observed. Pituitary apoplexy is defined as an acute clinical syndrome characterized with headache, vomiting, loss of vision, ophthalmoplegia and clouding of consciousness. The problem leading to pituitary apoplexy may be decreased blood supply in the adenoma and hemorrhage following this decrease or hemorrhage alone. In this article, we present a patient who presented with fever, vomiting and sudden loss of vision and limited outward gaze in the left eye following trauma and who was found to have pituitary macroadenoma causing compression of the optic chiasma and optic nerve on the left side on cranial and pituitary magnetic resonance imaging.

Relationship between newborn craniotabes and vitamin D status.

OBJECTIVE: In recent studies, vitamin D deficiency during pregnancy and early infancy has been reported to predispose children to many chronic diseases, except those of the skeletal system. The aim of this study was to investigate whether craniotabes in otherwise healthy newborns is physiological, its relationship to vitamin D deficiency and whether or not it requires treatment. METHODS: A total of 150 healthy newborns with a weight of over 2000 g were included. Newborns were divided into two groups during postnatal discharge (1-3.'s day): those with and without craniotabes. The 25-hydroxy (OH) vitamin D levels of the newborns' mothers were measured, and all infants were re-evaluated for craniotabes, as well as tested to determine levels of serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathyroid hormone (PTH) and 25(OH) vitamin D, urine calcium and creatinine. RESULTS: Craniotabes was present in 45 (30%) of newborns enrolled in the study. Craniotabes of the newborns born during the winter months was significantly higher. PTH level was significantly higher in 1-month-old newborns with craniotabes than those without craniotabes. No relationship was observed between diet and craniotabes, but in exclusively breastfed infants, vitamin D level was statistically significantly lower. No statistically significant difference was found in the occurrence of craniotabes in newborns with or without vitamin D support. CONCLUSION: The relationship between newborn craniotabes and maternal vitamin D deficiency is not clear. However, the present study illustrates that maternal vitamin D deficiency is still a major problem. Therefore, measures to prevent maternal vitamin D deficiency should be strengthened.

Relationship Between Obesity and Asthma Control in Children Aged 4-18 years.

OBJECTIVE: To analyze the relationship between obesity and asthma control in a group of patients with asthma. METHODS: In this prospective study, body mass index (BMI) values of 200 asthma patients aged 4-18 y who had been regularly followed up by Kartal Education and Research Hospital Pediatric Asthma Outpatient Clinic were calculated. Asthma control test (ACT) and asthma control questionnaire (ACQ) were performed. The degrees of asthma control were evaluated with regard to BMI values in consideration of the data obtained. RESULTS: The lowest and the highest BMI values were 12.4 and 30.0 kg/m(2), respectively (mean 18.1 ± 2.9). Of the total 200 children, 110 were boys and 90 were girls. It was found that 17 % of the patients were overweight and 16 % obese. ACT results showed that 72 patients had controlled asthma, 102 patients had partially controlled asthma and 26 patients had uncontrolled asthma. According to ACQ results, 165 patients had controlled asthma, 17 patients had partially controlled asthma and 18 patients had uncontrolled asthma. CONCLUSIONS: Thus, it was found that there was no statistically significant difference between asthma control degrees of obese and non-obese patients. In other words, obesity did not affect the asthma control level.

Severe childhood amitriptyline intoxication and plasmapheresis: a case report.

Tricyclic antidepressant intoxication is one of the most frequently encountered and life-threatening causes of intoxication among referrals to emergency departments due to drug intoxication. There is no known antidote against any of the tricyclic antidepressants. The American Society for Apheresis (ASFA) recommends plasmapheresis to support primary treatment in this type of drug poisoning, which does not respond to certain and traditional treatments. We present a 15-year-old girl who ingested amitriptyline with suicidal intent. On admission, she was in a comatose state (Glasgow Coma Scale score: 5), with no spontaneous respiration and presence of pathological reflexes. Due to the intake history of lethal doses and the severe clinical picture, plasmapheresis was performed. She was discharged on her fifth day of hospitalization.Due to the high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life-saving therapeutic modality.