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J Immunoassay Immunochem ; 33(2): 115-27, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22471602

RESUMEN

This article reports the first preparation of miniantibodies to Azospirillum brasilense Sp245 surface antigens by using a combinatorial phage library of sheep antibodies. The prepared phage antibodies were used for the first time for lipopolysaccharide and flagellin detection by dot assay, electro-optical analysis of cell suspensions, and transmission electron microscopy. Interaction of A. brasilense Sp245 with antilipopolysaccharide and antiflagellin phage-displayed miniantibodies caused the magnitude of the electro-optical signal to change considerably. The electro-optical results were in good agreement with the electron microscopic data. This is the first reported possibility of employing phage-displayed miniantibodies in bacterial detection aided by electro-optical analysis of cell suspensions.


Asunto(s)
Anticuerpos Antibacterianos/inmunología , Antígenos Bacterianos/inmunología , Antígenos de Superficie/inmunología , Azospirillum brasilense/inmunología , Azospirillum brasilense/aislamiento & purificación , Animales , Anticuerpos Antibacterianos/química , Azospirillum brasilense/clasificación , Técnicas Químicas Combinatorias , Electroquímica , Escherichia coli/inmunología , Flagelina/análisis , Flagelina/inmunología , Immunoblotting , Lipopolisacáridos/análisis , Lipopolisacáridos/inmunología , Microscopía Electrónica de Transmisión , Ovinos
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