Prevalence and trends of human papillomavirus in oropharyngeal cancer in a predominantly north Indian population.

BACKGROUND: Human papillomavirus (HPV) prevalence in oropharyngeal squamous cell cancer (SCC) remains variable and studies have estimated that up to 60% may be positive. METHODS: One hundred five treatment-naïve oropharyngeal SCC patients were included. HPV genotyping was done by consensus polymerase chain reaction (PCR) and reverse line-blot hybridization assay. HPV prevalence was co-related with sex, age, tobacco consumption, alcohol use, and high-risk sexual behavior. RESULTS: HPV prevalence was 22.8%. No significant associations were seen between tobacco or alcohol consumption with HPV status. The mean number of lifetime sexual partners and indulgence in high-risk sexual behavior was significantly more in patients who are HPV positive. There were no significant associations between the 2 groups with respect to the stage of the tumor. CONCLUSION: Results of this study confirms that patients who are HPV positive are younger, and with high-risk sexual behavior. We did not find any impact of smoking and alcohol consumption on HPV status.

Two rare cases of craniofacial chondrosarcoma.

The craniofacial region is a rare site for chondrosarcomas. These tumors may have osseous or extraosseous origin. Extraosseous chondrosarcomas have the same histological features as osseous chondrosarcomas. Chondrosarcomas usually present in the fifth to seventh decades of life, although several cases with younger age at presentation have been reported. They usually present as a painless mass that gradually progresses to various complaints, such visual impairment, nasal obstruction, and dental abnormalities. In this article, we present two cases of chondrosarcoma occurring at rather unusual locations. It is important to keep this rare malignancy in the list of differential diagnoses for a mass in the head and neck region, as these tumors may not always show the features typical of this malignancy.