RESUMEN
We evaluated the effectiveness and side effects of terodiline hydrochloride in 109 patients with urinary frequency and urinary incontinence. The drug was administered at a dose of 24 mg once a day or 12 mg twice a day for 4 weeks. Symptoms such as urinary frequency and urinary incontinence were alleviated in 101 out of 109 patients (92.7%). Mild side effects such as thirst, dysuria, sense of residual urine, orthostatic hypotension and arrhythmia were observed in 9 out of 109 patients (8.2%). Side effects such as orthostatic hypotension and arrhythmia were observed on the 28th day or the 20th day of the administration, but these symptoms disappeared with discontinued use of this medicine. The results obtained from this study suggest that terodiline hydrochloride may be greatly useful for the patients with urinary frequency and urinary incontinence. But we must take account of the side effects such as orthostatic hypotension and arrhythmia.
Asunto(s)
Butilaminas/uso terapéutico , Bloqueadores de los Canales de Calcio/uso terapéutico , Hemodinámica/efectos de los fármacos , Parasimpatolíticos/uso terapéutico , Incontinencia Urinaria/tratamiento farmacológico , Trastornos Urinarios/tratamiento farmacológico , Anciano , Anciano de 80 o más Años , Arritmias Cardíacas/inducido químicamente , Butilaminas/efectos adversos , Bloqueadores de los Canales de Calcio/efectos adversos , Evaluación de Medicamentos , Femenino , Humanos , Hipotensión Ortostática/inducido químicamente , Masculino , Persona de Mediana Edad , Parasimpatolíticos/efectos adversosRESUMEN
Intracavernous injection of various vasoactive drugs was performed in six erectile failure patients. The effects of each drug were evaluated in four grades: complete functional erection, incomplete functional erection, nonfunctional expansion and no effect. When papaverine hydrochloride (40 mg/ml) was administered, 4 of the 6 patients had nonfunctional expansion. By administering a mixture of 80 mg/ml papaverine hydrochloride with 1.0 mg/ml phentolamine mesylate, nonfunctional expansion was seen in four patients and incomplete functional erection in two patients. As for the effects of prostaglandin E1, incomplete functional erections were seen in all patients, while complete functional erection was seen in two patients. These findings indicated that the patients reacted differently to the same vasoactive drug, and that the papaverine and phentolamine mixture had a stronger effect than papaverine alone, while prostaglandin E1 had the strongest effect on erection. Intracavernous injection of the these drugs is useful for the treatment and differential diagnosis of impotence.
