RESUMEN
The present study was designed to evaluate basic differences in surface structure and viscoelastic properties of nonatopic versus atopic skin and facultative acute changes following ultraviolet irradiation. Therefore, biophysical measurements by means of profilometry and cutometry were carried out on sun-protected unaffected gluteal skin areas in both groups before and 24 h after single UVA and UVB irradiations. The results indicate that the clinically unaffected skin of patients with atopic eczema differs from normal skin in terms of increased roughness parameters, but not concerning depth of furrows or viscoelastic properties (viscosity and biological elasticity, cutometrically calculated). Single UVA irradiation with 50 J/cm(2) induced neither measurable changes in the skin's surface structure nor in its viscoelastic properties in both groups after 24 h. However, irradiation with a single erythemogenic dose of 1 MED UVB was followed by a short-term significant increase in the depths of furrows and decrease in biological elasticity in normal and atopic skin, accompanied by an increase in viscosity in normal skin.
Asunto(s)
Dermatitis Atópica/patología , Piel/patología , Piel/efectos de la radiación , Rayos Ultravioleta/efectos adversos , Adulto , Fenómenos Biomecánicos , Elasticidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , ViscosidadAsunto(s)
Erupciones por Medicamentos/diagnóstico , Amoxicilina/efectos adversos , Dermatitis Alérgica por Contacto/diagnóstico , Dermatitis Alérgica por Contacto/etiología , Dermatitis Alérgica por Contacto/patología , Erupciones por Medicamentos/etiología , Erupciones por Medicamentos/patología , Humanos , Masculino , Persona de Mediana Edad , Pruebas del Parche , Penicilinas/efectos adversos , SíndromeRESUMEN
The present study was designed to evaluate the effects of single irradiation either with UVA (dosage: 50 J/ cm2) or UVB (dosage: 1 MED) on surface structure and viscoelastic properties of human skin. Biophysical measurements by means of profilometry and cutometry were carried out on normally sunprotected skin areas directly before and 24 hours after irradiation. UVA induced neither measurable changes in skin surface structure (expressed by the profilometrically calculated parameters of roughness Ra and RzDIN and the parameter Wt reflecting depths of furrows) nor in its viscoelastic properties (expressed by the cutometrically calculated ratio Uv/Ue reflecting viscosity and the ratio Ur/Uf reflecting biological elasticity). However, a single erythemogenic dose of UVB radiation was followed by significant increase in the depths of furrows, increase in viscosity and decrease in biological elasticity.
Asunto(s)
Envejecimiento de la Piel/efectos de la radiación , Piel/efectos de la radiación , Rayos Ultravioleta/efectos adversos , Adolescente , Adulto , Relación Dosis-Respuesta en la Radiación , Elasticidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , ViscosidadRESUMEN
We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression. During this therapy he subsequently developed the following cutaneous neoplasms: squamous cell carcinomas, basal cell carcinomas, Bowen's disease, actinic keratosis, sebaceous hyperplasia, a dysplastic naevus and, finally a nodular malignant melanoma. Adverse effects of the cyclosporin A therapy are discussed, with special reference to dermatologic effects and the implications for patient and doctor.