[The results of micromorphological and histochemical studies of the musculocutaneous sac of nematodes in the suborder Oxyurata after anthelmintic exposure]. / Rezul'taty mikromorfologicheskikh i gistokhimicheskikh issledovanii kozhno-muskul'nogo meshka nematod podotriada Ozyurata posle vozdeistviia antigel'mintikov.

The paper presents the results of studies of the effects of anthelminthic agents on the in tegumentary tissues of nematodes from the Oxyurata suborder. All used anthelmintics causes varying structural changes in the integumentary tissues of Oxyurata. At the same time, there is swelling and loosening of the cuticle, its detachment from the subcuticular layer, vacuolization of the hypodermis and the plasma part of muscular cells, as well as irreversible changes in the cellular organoids of the hypodermis and muscular cells (destruction of canals of the endoplasmic network and the Golgi apparatus, mitochondrial membrane damage, nuclear pyknosis or lysis etc.)

[The structure and anthelmintic action of tricyclic analogs of praziquantel and 4-acylpiperazinones-2]. / Stroenie i antigel'mintnaia aktivnost' tritsiklicheskikh analogov prazikvantelia i 4-atsilpiperazinonov-2.

The toxicity and anthelminthic activity of the earlier synthetized tricyclic analogues of praziquantel and 4-acylpiperazinones-2 have been studied. Tricyclic compounds have shown the acute toxicity similar to that of praziquantel and neurotoxic effect typical of praziquantel. 4-acylpiperazinones-2 toxicity correlated with their anthelminthic effect. The determination of anthelminthic activity of the above compounds in opisthorchiasis and hymenolepiasis has shown that they are less effective than praziquantel or have no anthelminthic activity. A biological activity-structure relationship has been traced in the compounds under study.