[Immune activation and inflammation in chronic heart failure].

This survey shows that among chronic heart failure (CHF) and its characteristic inflammation observed mutual activation. Given the role of inflammation in the pathophysiology of heart failure, it is to study how the combination drug treatment of CHF, its variants influence on markers of inflammation. It is expedient to determine not only the level of cytokines, but also acute phase proteins (haptoglobin, seroglikoidy C3-complement, transferrin), reflecting inflammation and necrosis in the connective tissue, as well as IgA, IgG, IgM and protein spectrum. The importance of the study of haptoglobin due to its involvement in the metabolism of hemoglobin and transferrin--the exchange of iron.

[CHAPERONES FUNCTION HSP60 AND HSP90 AND THEIR ROLE IN CARDIAC PATHOLOGY].

In review provides information about the function oft the body of chaperones and their role in the development of pathological processes, including--atherosclerosis and coronary heart disease. Marked comminications systems chaperones to the immune and endocrine systems, and inflammation.

[Effect of pharmacotherapy of chronic heart failure (CHF) on the parameters of hemogram].

Found that different versions of the combined drug therapy of chronic heart failure accompanied by an increase of erythrocytes, hemoglobin in the blood of patients, color index, tended to increase hematocrit. The most pronounced changes are marked valid in the group of patients receiving the combination of ACE inhibitors + ARB-II + beta-blockers + diuretics. Found to have a direct positive correlation between hemoglobin levels and distance 6-minute test, the back - between hemoglobin and end-diastolic volume of the left ventricle, the functional class of heart failure. The number of red blood cells inversely correlated with functional class of heart failure, a direct positive - with a distance of 6-minute test.

[The etiological spectrum and immunosuppressive properties of the causative agents of pyoderma]. / Etiologicheskii spektr i nekotorye immunosupressivnye svoistva vozbuditelei piodermii.

The etiological spectrum and some immunoaggressive properties of microorganisms, that cause pyoderma in newborns which were isolated from patients have been studied. It was established that staphylococci (mostly coagulase-positive S. aureus, S. hyicus, S. intermedius) played the leading role in etiology of pyoderma, mostly in association with coagulase-negative staphylococci and (or) other conditionally pathogenic bacteria. Staphylococci occupying significant place in the skin diseases etiology are multiresistant to antibiotics and have valuable anti-lysozyme and anticomplement activities.

[The function of the blood neutrophils in diabetics]. / Funktsional'noe sostoianie neitrofilov krovi u bol'nykh sakharnym diabetom.

Studies made in 54 patients and "in vitro" experiment permitted finding out that insulin exerts major effect on the blood neutrophil functional status. It activates phagocytizing function of leucocytes as a result of intensification of glycolysis and cellular respiration, favours intracellular plastic processes. Elimination of hyperglycemia, insulin deficiency are prerequisites of success in correction of disturbances in phagocytizing function of cells in patients with diabetes mellitus.

[Functional disorders of the blood neutrophils and their correction in patients with bronchiectasis and lung abscess]. / Narusheniia funktsional'nogo sostoianiia neitrofilotsitov krovi i ikh korrektsiia u bol'nykh bronkhoéktaticheskoi bolezn'iu i abstsessom legkikh.

Studies conducted in 25 patients with bronchiectatic disease, 40 with chronic lung abscess, revealed decrement of the blood neutrophil capacity for uptaking bacteria, and cytochemical changes in these. Expediency of inclusion into the combination therapy of those drugs intensifying the leucocyte energy metabolism and phagocytic activity (vitamins C, B1, B2, B6, B12, PP, glutamic acid, prodigiosane, polyglucine) was validated in the experiment.