RESUMEN
Adaptive correction of structural and metabolic disturbances in the lungs caused by longterm exposure to coal-rock dust were studied in experiments on rats. It was shown that the complex antioxidant preparation containing dihydroquercetin compensated disturbances in the redox balance in the lung tissue, prevented the formation of dust granulomas, and reduced the severity of degenerative changes in the bronchopulmonary system.
Asunto(s)
Antioxidantes/farmacología , Carbón Mineral/efectos adversos , Radicales Libres/antagonistas & inhibidores , Expresión Génica/efectos de los fármacos , Granuloma/prevención & control , Quercetina/análogos & derivados , Administración Oral , Alanina Transaminasa/genética , Alanina Transaminasa/metabolismo , Animales , Animales no Consanguíneos , Aspartato Aminotransferasas/genética , Aspartato Aminotransferasas/metabolismo , Catalasa/genética , Catalasa/metabolismo , Esquema de Medicación , Polvo , Radicales Libres/metabolismo , Granuloma/etiología , Granuloma/genética , Granuloma/patología , Proteínas del Choque Térmico HSP72/genética , Proteínas del Choque Térmico HSP72/metabolismo , Hemo Oxigenasa (Desciclizante)/genética , Hemo Oxigenasa (Desciclizante)/metabolismo , Hidroxibutirato Deshidrogenasa/genética , Hidroxibutirato Deshidrogenasa/metabolismo , Subunidad alfa del Factor 1 Inducible por Hipoxia/genética , Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo , Exposición por Inhalación/efectos adversos , Pulmón/efectos de los fármacos , Pulmón/metabolismo , Pulmón/patología , Masculino , Oxidación-Reducción , Tamaño de la Partícula , Quercetina/farmacología , Ratas , Superóxido Dismutasa/genética , Superóxido Dismutasa/metabolismoRESUMEN
The studies revealed specificity of morphologic changes in target organs, depending on acting occupational hazard. Evidences are that inhalation of coal rock dust causes irreversible sclerotic and degenerative changes mostly in lungs and bronchi even on 6th week of the experiment. In liver, changes in parenchyma and stroma are controlled by reparative processes by 9th week. Accumulation of sodium fluoride in the body causes irreversible necrotic changes mostly in liver, on 6th week of the intoxication. With that, morphologic changes in lungs and bronchi are minor, characterized by immune inflammation with degenerative changes only after the 9th week. Irrespective of the acting hazard, vascular changes are characterized by media and intima hypertrophy with endothelial dystrophy and hyalinosis since the 6th week of the experiment.
