RESUMEN
Armatenols A-C (1-3), new isoflavan-4-ols, have been isolated from the CHCl3-soluble sub-fraction of Colutea armata Hemsl. & Lace, along with two known compounds namely 8-methoxyvestitol (4) and colutequinone (5), reported for the first time from this species. Their structures have been elucidated through spectroscopic techniques including MS, IR, UV, CD, 1 D and 2 D NMR. Compounds 1-2 invariably showed significant antioxidant activity using the methods of 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity (DPPH), Fe3+ reducing antioxidant power (FRAP) assay and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) radical scavenging activity (ABTS).
Asunto(s)
Antioxidantes , Fabaceae , Antioxidantes/farmacología , Antioxidantes/química , Fabaceae/química , Espectroscopía de Resonancia MagnéticaRESUMEN
Abstract Cashmirins A (1) and B (2), new prenylated coumarins, have been isolated from the EtOAc- soluble fraction of the whole plant of Sorbus cashmiriana Hedlung, Monog. along with seselin (3), scopoletin (4), 3-hydroxyxanthyletin (5) and luteolin (6), reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS, 1D and 2D NMR spectroscopy. Both new compounds 1 and 2 were investigated for biological activities and showed significant antifungal and urease inhibitory activities. Compounds 1 and 2 exhibited significant activity against Aspergillus flavus, Macrophomina phaseolina, Trichophyton simii, Trichophyton schoenleinii, and Pseudallescheria boydri. Both compounds also exhibited significant inhibitory activity against Jack bean urease with IC50 values of 28.2±0.12 µM and 30.3±0.18 µM, respectively compared to thiourea used as positive control.
RESUMEN
Brahucins A (1) and B (2), the new oleanane-type triterpene lactones, have been isolated from the EtOAc-soluble fraction of Spiraea brahuica Boiss, along with betulinic acid (3), oleanolic acid (4), 3-O-(ß-D-glucopyranosyl) oleanolic acid (5), vanillic acid (6) and caffeic acid (7), reported for the first time from this species. The structures of these compounds were elucidated by spectroscopic studies including MS, IR, 1D and 2D NMR.
Asunto(s)
Saponinas , Spiraea , Triterpenos , Lactonas , Estructura MolecularRESUMEN
Colucins A (1) and B (2), new flavonoids and colucone (3), the new chalcone derivative, have been isolated from the CHCl3-soluble fraction of the whole plant of Colutea armata along with luteolin (4), luteolin 7-O-ß-D-glucoside (5), isoliquiritigenin (6), trans-caffeic acid (7) and stigmasterol (8) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Compounds 1 and 2 showed significant antimicrobial activity against two Gram positive and three Gram negative bacterial strains while 3 was moderately active.
Asunto(s)
Antibacterianos/farmacología , Chalconas/farmacología , Fabaceae/química , Flavonoides/farmacología , Antibacterianos/aislamiento & purificación , Chalconas/aislamiento & purificación , Flavonoides/aislamiento & purificación , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Extractos Vegetales/química , Extractos Vegetales/farmacologíaRESUMEN
Two new lupene-type triterpenes, sorbicins A and B, have been isolated from the chloroform-soluble fraction of the MeOH extract from the whole plant of Sorbus cashmiriana, and their structures were elucidated by spectroscopic techniques including 2D NMR. Both compounds displayed urease and α-chymotrypsin inhibitory potential.
Asunto(s)
Inhibidores de Serina Proteinasa/aislamiento & purificación , Inhibidores de Serina Proteinasa/farmacología , Sorbus/química , Triterpenos/aislamiento & purificación , Triterpenos/farmacología , Ureasa/antagonistas & inhibidores , Quimotripsina/antagonistas & inhibidores , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Pakistán , Inhibidores de Serina Proteinasa/química , Triterpenos/químicaRESUMEN
Two new triterpenes, cashmirols A and B, along with three known compounds have been isolated from the AcOEt-soluble fraction of Sorbus cashmiriana, and their structures were elucidated by spectroscopic techniques including two-dimensional NMR. Both compounds displayed lipoxygenase enzyme inhibitory potential.
Asunto(s)
Lipooxigenasa/química , Sorbus/química , Triterpenos/química , Lipooxigenasa/metabolismo , Inhibidores de la Lipooxigenasa/química , Inhibidores de la Lipooxigenasa/farmacología , Espectroscopía de Resonancia Magnética , Conformación Molecular , Triterpenos/aislamiento & purificación , Triterpenos/farmacologíaRESUMEN
Two new pentacyclic triterpenes, sorbinols A (1) and B (2) have been isolated from the ethyl acetate fraction of Sorbus cashmariana and their structures assigned from (1)H and (13)C NMR spectra, DEPT and by 2D COSY, NOE, HMQC and HMBC experiments. Both 1 and 2 showed moderate inhibitory potential against the enzyme lipoxygenase.