RESUMEN
Results of clinical trial of the new pyrimidine derivative--ximedone are presented. The drug was administered per os 0.5 g x 4 times a day (0.5 h before meals). Total course dose achieved 60 g. Ximedone implementation for complex treatment of burns, trophic ulcer of lower limbs, different inflammations demonstrated positive results. Prophylaxy administration of the drug in abdominal surgery at acute appendix resulted with lower incidence of postoperative complications. High efficacy and good tolerability of the drug allows to recommend it for wide medical use.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Pirimidinas/uso terapéutico , Profilaxis Antibiótica , Quemaduras/tratamiento farmacológico , HumanosRESUMEN
Pharmacotoxicological properties of ximedone, a new pyrimidine derivative, were studied experimentally on animals of various species. In the enteral regimen the drug had a favourable effect on thermal burns and postoperative cutaneous and gastric wounds. The results enabled to recommend ximedone for the clinical practice.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Quemaduras/tratamiento farmacológico , Pirimidinas/uso terapéutico , Infección de la Herida Quirúrgica/tratamiento farmacológico , Adyuvantes Inmunológicos/toxicidad , Animales , Evaluación Preclínica de Medicamentos , Cobayas , Dosificación Letal Mediana , Ratones , Complicaciones Posoperatorias/prevención & control , Pirimidinas/toxicidad , Conejos , Ratas , Ratas Wistar , Cicatrización de Heridas/efectos de los fármacosRESUMEN
The paper proposes a working classification of devices for intra- and extrafocal transtissue vulnosynthesis with the concurrent use of the agents that enhance reparative regeneration. Evaluating wound closure with wound adapters or routine suture has shown the advantages of the techniques by employing the proposed devices: the latter accelerates and facilitates suture application reparative, increases atraumaticity, asepticity, creates conditions for forming a precision suture. The positive results of experimental studies and clinical observations suggest that wound adapters have promises in practical application, transtissue device-aided vulnosynthesis in combination with topical pyrimidine derivatives, such as ximedon, shows great opportunities in soft tissue lesions.