RESUMEN
A Staffordshire terrier presented for evaluation of a chronic, nonproductive cough that was unresponsive to antibiotic therapy. A large mass identified in the pulmonary hilum was most consistent with tracheobronchial lymphadenopathy on radiographic and computed tomography (CT) images. Bronchoscopy confirmed a mass compressing the dorsal portion of the intrathoracic trachea. Bronchoscopic biopsies of the tracheal mass revealed necrosuppurative and eosinophilic inflammation with intralesional Pythium insidiousum hyphae. Pythiosis should be included as a differential diagnosis for tracheobronchial lymphadenopathy and bronchopneumopathy in dogs, especially when the patient is from or has visited a region endemic for Pythium insidiosum.
Asunto(s)
Enfermedades Bronquiales/veterinaria , Tos/veterinaria , Enfermedades de los Perros/diagnóstico , Enfermedades Pulmonares/veterinaria , Linfadenopatía/veterinaria , Pitiosis/diagnóstico , Enfermedades de la Tráquea/veterinaria , Animales , Enfermedades Bronquiales/diagnóstico , Enfermedades Bronquiales/diagnóstico por imagen , Enfermedades Bronquiales/microbiología , Broncoscopía/veterinaria , Tos/diagnóstico por imagen , Diagnóstico Diferencial , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/microbiología , Perros , Enfermedades Pulmonares/diagnóstico , Enfermedades Pulmonares/diagnóstico por imagen , Enfermedades Pulmonares/microbiología , Linfadenopatía/diagnóstico , Linfadenopatía/diagnóstico por imagen , Linfadenopatía/microbiología , Masculino , Pitiosis/diagnóstico por imagen , Pitiosis/microbiología , Pythium/fisiología , Radiografía/veterinaria , Tomografía Computarizada por Rayos X/veterinaria , Enfermedades de la Tráquea/diagnóstico , Enfermedades de la Tráquea/diagnóstico por imagen , Enfermedades de la Tráquea/microbiologíaAsunto(s)
Enfermedades del Colon/veterinaria , Enfermedades de los Perros/diagnóstico por imagen , Vólvulo Intestinal/veterinaria , Animales , Enfermedades del Colon/diagnóstico por imagen , Enfermedades del Colon/cirugía , Enfermedades de los Perros/cirugía , Perros , Obstrucción Intestinal , Vólvulo Intestinal/diagnóstico por imagen , Vólvulo Intestinal/cirugía , Masculino , Radiografía Abdominal/veterinaria , Radiografía Torácica/veterinariaAsunto(s)
Enfermedades de los Gatos/diagnóstico , Degeneración del Disco Intervertebral/veterinaria , Animales , Enfermedades de los Gatos/patología , Gatos , Soluciones Cristaloides , Dexametasona/administración & dosificación , Dexametasona/uso terapéutico , Degeneración del Disco Intervertebral/diagnóstico , Degeneración del Disco Intervertebral/cirugía , Soluciones Isotónicas/uso terapéutico , Laminectomía/métodos , Laminectomía/veterinaria , Masculino , Meloxicam , Paraparesia/diagnóstico , Paraparesia/patología , Paraparesia/veterinaria , Tiazinas/administración & dosificación , Tiazinas/uso terapéutico , Tiazoles/administración & dosificación , Tiazoles/uso terapéuticoRESUMEN
The endogenous cannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) play vital roles during nervous system development. The degradation of 2-AG and AEA is mediated by monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. These enzymes are inhibited following developmental chlorpyrifos (CPF) exposure. To investigate whether this inhibition is persistent or whether accumulation of endocannabinoids in the brain occurs, 10-day-old rat pups were orally exposed daily for 7 days to either corn oil or increasing dosages of CPF (1, 2.5, or 5mg/kg), and forebrains were collected at 4, 12, 24, and 48h following the last administration. All dosages inhibited cholinesterase (ChE), FAAH, and MAGL, and elevated AEA and 2-AG levels with the greatest effect occurring at 12h with ChE, FAAH, AEA, and 2-AG and at 4h with MAGL. With the high dosage, return to control levels occurred with 2-AG (48h) only. With the medium dosage, return to control levels occurred with MAGL, 2-AG, and AEA (48h) but not with ChE or FAAH. With the low dosage, return to control levels occurred with MAGL (12h), ChE and 2-AG (24h), and AEA (48h) but not with FAAH. With the lowest dosage, peak inhibition of FAAH (52%) is greater than that of ChE (24%) and that level of FAAH inhibition is sufficient to induce a persistent pattern of elevated AEA. It is possible that this pattern of elevation could alter the appropriate development of neuronal brain circuits.