Asunto(s)
Glucosiltransferasas/genética , Hiperpigmentación/genética , Mutación Missense/genética , Enfermedades Cutáneas Genéticas/genética , Enfermedades Cutáneas Papuloescamosas/genética , Anciano , Femenino , Humanos , Hiperpigmentación/diagnóstico , Masculino , Persona de Mediana Edad , Linaje , Enfermedades Cutáneas Genéticas/diagnóstico , Enfermedades Cutáneas Papuloescamosas/diagnósticoRESUMEN
BACKGROUND: Cutaneous scleroderma is a chronic inflammatory disease of the dermal and subcutaneous connective tissue leading to sclerosis. Sclerosis of the skin can lead to dysmorphism, contractures and restrictions of movement. OBJECTIVE: The purpose of the study was to evaluate sclerosis in cutaneous scleroderma patients and to determine the efficacy of water-filtered infrared A plus visible light treatment, wIRA(+VIS), in 10 patients. METHODS: Hardness of the normal and diseased skin was measured by durometry in 10 controls and 8 patients. Moreover, circumscribed scleroderma (CS) was treated with wIRA(+VIS) irradiations in 10 patients who had not responded to conventional therapies. RESULTS: wIRA(+VIS) therapy led to a marked improvement, persistent even during long-term follow-up, in 7 out of 10 patients with CS. Of the other patients, 1 showed decreased sclerosis and disease activity and developed a worsening after cessation of therapy. In 2 further patients, where previous UVA1 treatment had failed to reduce disease activity, wIRA(+VIS) produced a slight decrease in sclerosis, but disease activity was still present. CONCLUSION: wIRA(+VIS) appears to be effective in the treatment of CS. Durometry proved to be helpful in assessing the degree of sclerosis and in documenting the response to therapy in these patients.
Asunto(s)
Rayos Infrarrojos/uso terapéutico , Fototerapia , Esclerodermia Sistémica/terapia , Adolescente , Adulto , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Agua/química , Adulto JovenAsunto(s)
Hemangioma Cavernoso/congénito , Hemangioma/congénito , Neoplasias Cutáneas/congénito , Antagonistas Adrenérgicos beta/efectos adversos , Antagonistas Adrenérgicos beta/uso terapéutico , Progresión de la Enfermedad , Femenino , Hemangioma/diagnóstico , Hemangioma/tratamiento farmacológico , Hemangioma Cavernoso/diagnóstico , Hemangioma Cavernoso/tratamiento farmacológico , Humanos , Lactante , Recién Nacido , Regresión Neoplásica Espontánea , Producción de Medicamentos sin Interés Comercial , Pronóstico , Propranolol/efectos adversos , Propranolol/uso terapéutico , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/tratamiento farmacológico , Ultrasonografía , Ultrasonografía Doppler DúplexRESUMEN
Perianal streptococcal dermatitis is a common disease. The typical clinical picture includes perianal erythema, pruritus, painful defaecation and bloody stools. The diagnosis is made by a swab taken from the affected skin with bacterial culture. Therapy consists of penicillin for 10 days. Screening for affected persons in contact with the patient is indicated because perianal streptococcal dermatitis is known to be highly contagious. Relapse is common and therefore follow-up visits are recommended. In case of relapse, a first or second generation cephalosporin may be considered.
