Concurrent Force Feedback on Load Symmetry in Total Knee Arthroplasty Patients.

Background and Purpose: Load asymmetry can be present before and after total knee arthroplasty (TKA), which may affect progress during knee rehabilitation in an outpatient sports medicine setting. Current rehabilitation primarily focuses on strength, pain, and range of motion deficits; however, recent evidence suggests the use of movement retraining strategies such as load feedback to address load asymmetry. Therefore, the purpose of this study was to examine how a single session of concurrent force feedback influences load symmetry during the leg-press and body-weight squat exercises in individuals following TKA. Additionally, a secondary purpose was to examine the retention of any changes over the course of a week. Study design: Case-series study. Methods: This observational, repeated-measures study design examined the effect of concurrent force feedback training on the mean and standard deviation of load symmetry index during the leg press and squat exercises in 26 patients with TKA in an outpatient sports medicine clinic.The load asymmetry was measured with loadpad sensors placed underneath the each extremity during leg press and squat (baseline), after one training session consisting of concurrent force feedback during these exercises within a single physical therapy session (post feedback), and after seven to ten days of a washout period (post retention). Separate 2 x 3 repeated measures analysis of variance was used to compare the mean and standard deviation of load symmetry across exercise (leg press and squat) and across time (baseline, post feedback and post retention). Results: There was a time effect for the mean load symmetry index (p=0.027) but not for the standard deviation (p=0.441) during these exercises. The leg press showed a greater mean symmetry index compared to the squat regardless of time (p=0.001). Conclusions: A reduction in the mean load symmetry index following concurrent feedback training suggests improved use of the surgical limb during both leg press and squat exercises during the same therapy session but the more symmetric loading pattern was not retained one week later. Overall, the leg press showed greater mean asymmetry than the squat. Standard deviation in the load symmetry index did not change across time or by exercise. Level of Evidence: 3©The Author(s).

Effects of Body Weight Support in Running on Achilles Tendon Loading.

Achilles tendon (AT) tendinopathy is common in runners. Repetitive AT loading may play a role in etiology. Interventions such as body weight support (BWS) may reduce loading on the AT in running. Examine how ground reaction force, AT loading, foot strike, and cadence variables change in running with BWS. Twenty-four healthy female runners free from injury were examined. Participants ran on an instrumented treadmill with and without BWS using a harness-based system at a standardized speed. The system has 4 elastic cords affixed to a harness that is attached to a frame-like structure. Kinematic data and kinetic data were used in a musculoskeletal model (18 segments and 16 degrees of freedom) to determine AT loading variables, foot strike angle, and cadence. Paired t-tests were used to compare each variable between conditions. Ground reaction force was 9.0% lower with BWS (p<.05). Peak AT stress, force, and impulse were 9.4, 11.7%, and 14.8% lower when using BWS in running compared to no support (p<.05). Foot strike angle was similar (p<.05) despite cadence being reduced (p<.05). BWS may reduce AT loading and impulse variables during running. This may be important in rehabilitation efforts.

Alterations in Achilles tendon stress and strain across a range of running velocities.

Running has a high incidence of overuse injuries. Achilles tendon (AT) injuries may occur due to high forces and repetitive loading during running. Foot strike pattern and cadence have been linked to the magnitude of AT loading. The effect of running speed on AT stress and strain, muscle forces, gait parameters and running kinematics is not well addressed in recreational runners with lower pace of running. Twenty-two female participants ran on an instrumented treadmill between 2.0 and 5.0 m/s. Kinetic and kinematic data were obtained. AT cross-sectional area data were collected using ultrasound imaging. Inverse dynamics with static optimization was used to calculate muscle forces and AT loading. AT stress, strain and cadence increased with greater running speed. Foot inclination angle indicated a rearfoot strike pattern among all participants, which increased as running speed increased but the latter plateaued after 4.0 m/s. The soleus contributed more force in running compared to the gastrocnemius throughout all speeds. Highest running speeds had the most stress on the AT, with changes to foot inclination angle and cadence. Understanding the relation of AT loading variables with running speed may aid in understanding how applied load may influence injury.

Dynamic postural control in injured collegiate cross-country runners is not associated with running-related injury.

BACKGROUND: Biomechanical factors have been associated with running-related injury, but associations are unclear. Dynamic postural stability may be a factor related to injury that has not been studied extensively. RESEARCH QUESTION: Does dynamic postural control differ in those with a history of running-related injury or those who go on to sustain a running-related injury? METHODS: Sixty-five (45 injured; 20 uninjured) and fifty-eight (13 injured; 45 uninjured) collegiate cross-country runners were available for our retrospective and prospective analyses. Time to stabilization and dynamic postural stability index were collected during two separate jump landing tasks (forward and lateral direction) for each leg. Retrospective injury was tabulated by a running history survey. Prospective injuries were recorded by a licensed athletic trainer during the competitive season. Differences in postural stability were compared between injured and uninjured groups and between limbs using two-way ANOVA's. An overall group by leg comparison was completed for each task. RESULTS: The non-dominant limb demonstrated better postural stability indices regardless of injury history. An interaction was observed between limbs and history of injury for the anterior-posterior time to stabilization for the lateral task. The non-dominant limb demonstrated better medio-lateral postural stability indices and time to stabilization during the lateral task, regardless of prospective injury. SIGNIFICANCE: Dynamic postural stability was reduced in the dominant limb, but no clear differences were seen between injured and uninjured runners. This suggests dynamic postural stability may be altered in individuals with a history of a running-related injury, but no relationship to subsequent injury was substantiated. Further work is needed to understand how dynamic postural stability may be related to running-related injury.

Kinematic and muscle force asymmetry in healthy runners: How do different methods measure up?

BACKGROUND: Comparing the performance of one leg to another is a common means of assessing running gait to help inform clinical management strategies. Various methods are employed to quantify asymmetries between limbs. However, limited data is available describing the amount of asymmetry that may be expected during running and no index has been identified as preferable for making a clinical determination of asymmetry. Therefore, this study aimed to describe amounts of asymmetry in collegiate cross-country runners and compare different methods of calculating asymmetry. RESEARCH QUESTION: What can be expected as a normal amount of asymmetry in biomechanical variables in healthy runners when using different indices to quantify limb symmetry? METHODS: Sixty-three (29 male and 34 female) runners participated. Running mechanics were assessed during overground running using 3D motion capture and a musculoskeletal model using static optimization to estimate muscle forces. Independent t-tests were utilized to determine statistical differences in variables between legs. Different methods of quantifying asymmetry were then compared to statistical differences between limbs to determine cut-off values and the sensitivity and specificity of each method. RESULTS: A large portion of runners demonstrated asymmetry during running. Kinematic variables can be expected to have small differences (2-3 degrees) between limbs while muscle forces may show greater amounts of asymmetry. The sensitivities and specificities for each method of calculating asymmetry were similar, however, different methods led to different cut-off values for each variable investigated. SIGNIFICANCE: Asymmetry can be expected between limbs during running. However, when assessing asymmetry, practitioners should consider the joint, variable, and method of calculating asymmetry when determining differences between limbs.

Added mass increases Achilles tendon stress in female runners.

CONTEXT: Achilles tendon (AT) injuries are common in female runners and military personnel where increased AT loading may be a contributing factor. Few studies have examined AT stress during running with added mass. The purpose was to examine the stress, strain, and force placed on the AT, kinematics and temporospatial variable in running with different amounts of added mass. DESIGN: Repeated measure design METHODS: Twenty-three female runners with a rear-foot strike pattern were participants. AT stress, strain, and force were measured during running using a musculoskeletal model that used kinematic (180 Hz) and kinetic data (1800 Hz) as input. Ultrasound data were used to measure AT cross sectional area. A repeated measures multivariate analysis of variance (α = 0.05) was used on AT loading variables, kinematics and temporospatial variables. RESULTS: Peak AT stress, strain, and force were greatest during the 9.0 kg added load running condition (p < .0001). There was a 4.3% and 8.8% increase in AT stress and strain during the 4.5 kg and 9.0 kg added load conditions, respectively, compared to baseline. Kinematics at the hip and knee changed with added load but not at the ankle. Small changes in temporospatial variables were seen. CONCLUSION: Added load increased stress on the AT during running. There may be an increased risk for AT injury with added load. Individuals may consider slowly progressing training with added load to allow for increased AT loading.

An Updated Model Does Not Reveal Sex Differences in Patellofemoral Joint Stress during Running.

Background: Structure-specific loading may have implications in understanding the mechanisms of running related injury. As females demonstrate a prevalence of patellofemoral pain twice that of males, this may indicate differences in patellofemoral loads between males and females. Previous works investigating differences in patellofemoral joint stress have shown conflicting results, but the models employed have not used estimates of muscle forces or sex specific contact areas. Hypothesis/Purpose: The aim of this study was to examine sex differences in patellofemoral joint stress using an updated model to include estimates of quadriceps muscle force and sex-specific patellofemoral contact area. Study Design: Descriptive Laboratory Study. Methods: Forty-five healthy recreational runners ran at a controlled speed down a 20-meter runway. Kinetic and kinematic data were utilized to estimate muscle forces using static optimization. Quadriceps muscle force was utilized with sex-specific patellofemoral joint contact area in a two-dimensional patellofemoral joint model to estimate patellofemoral joint stress. Multivariate tests were utilized to detect sex differences in patellofemoral loading and hip and knee kinematics. Results: No differences were found between sexes in measures of patellofemoral loading or quadriceps force. Females displayed a reduced knee extension moment and greater hip adduction and internal rotation than males. Conclusion: The inclusion of static optimization to estimate quadriceps muscle force and sex-specific contact area of the patellofemoral joint did not reveal sex differences in patellofemoral joint stress, but differences in non-sagittal plane hip motion were detected. Therefore, two-dimensional patellofemoral models may not fully characterize differences in patellofemoral joint stress between males and females. Three-dimensional patellofemoral models may be necessary to determine if sex differences in patellofemoral joint stress exist. Level of Evidence: 3b.

Offloading Effects on Impact Forces and Patellofemoral Joint Loading During Running in Females.

BACKGROUND: Structure-specific loading is being increasingly recognized as playing a role in running related injuries. The use of interventions targeted at reducing patellofemoral joint loads have shown effectiveness in reducing symptoms of patellofemoral pain. Use of bodyweight support (BWS) has the potential to reduce loading on the patellofemoral joint during running to augment rehabilitation efforts. RESEARCH QUESTION: How is patellofemoral joint loading different when using a harness-based BWS system during running? METHODS: Twenty-five healthy females free from lower extremity injury were included. Participants completed four running trials on an instrumented treadmill with varying amounts of BWS using a commercially available harness system. Kinematic data from a 3D motion capture system and kinetic data from the treadmill were combined in a computer model to estimate measures of patellofemoral joint loading, knee kinematics, ground reaction force, and stride frequency. RESULTS: Peak patellofemoral joint stress and time-integral were reduced when running under BWS conditions compared to control conditions. Incremental decreases in patellofemoral loading were not observed with incremental increases in BWS. Peak knee flexion angle was reduced in all BWS conditions compared to control but was not different between BWS conditions. Knee flexion excursion was reduced in only the high BWS condition. Peak ground reaction force and stride frequency incrementally decreased with increased amounts of BWS. SIGNIFICANCE: Harness-based BWS systems may provide a simple means to reduce patellofemoral joint loading to assist in rehabilitation efforts, such as addressing patellofemoral pain.

Two-dimensional versus three-dimensional measurement of infant cervical active motion.

INTRODUCTION: Upright infant active cervical motion (ACM) is difficult to measure accurately by a single examiner. Clinically, physical therapists use visual estimation, which has limited reliability and concurrent validity with gold standards. Consistent, reliable, and valid active motion measurements are needed to document infant status and response to intervention. PURPOSE: Two-dimensional (2D) photo digitization measurements were compared to three-dimensional (3D) motion analysis measures of infant active neck rotation and lateral flexion. METHODS: Typically-developing infants participated (five boys, nine girls; 3-7.5 months). An experienced pediatric physical therapist and six novice raters marked photographs and used two different 2D methods to measure cervical rotation and three different 2D methods to measure cervical lateral flexion in photographs. To determine the intra- and interrater reliability of the 2D measurement methods and their concurrent validity with the 3D measures, a subset of lateral flexion photos was marked and measured by 14 experienced pediatric physical therapists. RESULTS: Novice and experienced examiner measurements of 2D ACM exhibited moderate to excellent intra- and inter-rater reliability. The results of the 2D lateral flexion ACM measurements completed by novice and experienced raters consistently differed from those obtained using the 3D measurement methods. CONCLUSION: The 2D rotation ACM measurement methods were reliable and demonstrated concurrent validity with the gold standard 3D measure. Infants' lateral flexion ACM examined using 2D measures did not correlate with the results of 3D measurements. This indicated that 2D measurements of active infant cervical lateral flexion could not be used as a valid indicators of 3D motion.

Kinetic changes associated with extended knee landings following anterior cruciate ligament reconstruction in females.

OBJECTIVES: To determine the relationship between knee flexion excursion symmetry and lower extremity kinematics, kinetics, and muscle, joint, and ligament forces in females 1-3 years after ACL reconstruction. DESIGN: Cross-sectional. SETTING: Laboratory. PARTICIPANTS: Twenty-one, college-aged females. MAIN OUTCOME MEASURES: Lower extremity kinetics and kinematics, including estimated muscle, tibiofemoral, and ligament forces were assessed using 3D motion analysis and a musculoskeletal modeling approach. Participants demonstrating greater than 10% asymmetry in knee flexion excursion were classified as landing with an "extended knee". Group and between-limb differences were compared. RESULTS: Ten participants were classified as landing with an "extended knee" on the involved limb, while eleven exhibited a symmetric landing pattern. Participants landing with an "extended knee" demonstrated reduced knee extension moment and quadriceps force in the involved limb (p < 0.05). CONCLUSIONS: These findings indicate that an "extended knee" landing pattern was associated with reduced knee extension moment and quadriceps muscle force in females 1-3 years after ACL reconstruction. This may represent an altered strategy that clinicians may choose to identify and address during rehabilitation.

Changes in landing mechanics using augmented feedback: 4-Week training and retention study.

CONTEXT: Non-contact ACL injuries are common in female athletes during landing tasks. Post-trial performance-based feedback may be an effective method to reduce landing forces and knee valgus during landing. Information regarding the retention of these changes based on such training is generally lacking for weekly and monthly retention. OBJECTIVE: To determine the effectiveness of post-trial feedback training to promote and retain changes in vertical ground reaction force (vGRF) and knee to ankle (K:A) ratio during a dual task drop landing in female collegiate athletes. DESIGN: Repeated measures; SETTING: University campus. PARTICIPANTS: 22 female collegiate athletes. MATERIALS AND METHODS: Dual task drop landings were performed over 4 successive weeks with immediate post trial feedback on peak vGRF, symmetry, and K:A ratio. K:A ratio was a surrogate measure for knee valgus in drop landing. RESULTS: Significant decreases in vGRF and increases in K:A ratio were found within training sessions (p = .000). Both variables were retained each week over the 4 weeks. CONCLUSION: Using a custom portable clinical feedback system may be an effective tool in reducing peak vGRFs and knee abduction angles during a drop landing over a 4-week period in female collegiate athletes.

Effect of Increasing Running Cadence on Peak Impact Force in an Outdoor Environment.

BACKGROUND: An estimated 56% of recreational runners sustain a running-related injury related to the high impact forces in running. Increasing step frequency (cadence) while maintaining a consistent speed has been shown to be an effective way to lower impact forces which may reduce injury risk. PURPOSE: To examine effects of increased cadence on peak impact force during running in an outdoor setting. It was hypothesized that as cadence increases, peak force would decrease. STUDY DESIGN: Repeated measures, quasi-experimental. METHODS: Peak force and cadence measurements were collected from 15 recreational runners (8 females, 7 males) during two 2.4-mile outdoor runs. Peak force was measured using an insole-based load measuring device. Baseline session run was completed at participant's naturally preferred cadence and cadence session run was completed at a cadence targeted to be 10% greater than baseline. Pace was monitored with a GPS watch. Cadence was cued by an auditory metronome and measured with both GPS watch and insoles. Repeated-measures ANOVA's examined the differences in average peak force, GPS-reported cadence, and insole-reported cadence between mile 1 and mile 2, and across the two cadence conditions. RESULTS: Cadence differences of 7.3% were observed between baseline and cadence sessions (p<0.001). A concurrent decrease in average peak force of 5.6% was demonstrated during the cadence run (p<0.05). Average cadences measured by GPS watch and insoles were found to be the same at both baseline (p=0.096) and during cadence (p=0.352) sessions. CONCLUSION: Increasing cadence by an average of 7% in an outdoor setting resulted in a decrease in peak force at two different time points during a 2.4-mile run. Furthermore, using a metronome for in-field cadence manipulation led to a change in cadence. This suggests that a metronome may be an effective tool to manipulate cadence for the purpose of decreasing peak impact force in an outdoor setting. LEVEL OF EVIDENCE: 3b.

Post-Trial Feedback Alters Landing Performance in Adolescent Female Athletes Using a Portable Feedback System.

BACKGROUND: Post-performance verbal and visual feedback based on data collected via lab-based instruments have been shown to improve landing patterns related to non-contact ACL injury. Biomechanical methods are often complex, difficult to transport and utilize in field settings, and costly, which limits their use for injury prevention. Developing systems that can readily provide feedback outside of the lab setting may support large scale use of feedback training for ACL injury prevention. PURPOSE/HYPOTHESIS: The purpose of this study was to investigate the effectiveness of a single training session using a custom portable feedback training system that provides performance cues to promote changes in impact kinetics and lower extremity position during landing in female athletes. STUDY DESIGN: Repeated measures. METHODS: One hundred fifty female athletes (ages 13-18 years old) landed from a 50 cm platform with and without feedback related to vertical ground reaction force (vGRF), vGRF symmetry and lower extremity position. Feedback was provided via a portable, low-cost system that included two custom-built force plates interfaced with a digital camera. Each athlete performed six pre-test trials followed by two blocks of six trials where they received visual feedback from the training system and individualized verbal cues from an investigator. Following training blocks, athletes completed six post-test trials without feedback and then six dual-task trials where a ball was randomly thrown to the performer during the landing (transfer task). vGRF and knee to ankle (K:A) separation ratio were measured and the average responses were reported for each trial block. RESULTS: Differences in vGRF between baseline, post-test and transfer task trial blocks were observed (F(2,298)=181.68, p < .0001). Mean (SD) peak vGRF (body weight) were 4.43 (0.90), 3.28 (0.61), and 3.80 (0.92), respectively. Differences in K:A ratio between baseline, post-test and transfer task trial blocks were shown (F(2,298)=68.47, p < .0001). Mean (SD) K:A ratio were 0.87 (0.21), 0.98 (0.19), and 0.92 (0.19), respectively. CONCLUSION: A portable feedback system may be effective in reducing peak vGRFs and promoting a more desirable K:A ratio during landing and transfer task landing in adolescent female athletes. LEVEL OF EVIDENCE: 3b.

Normative Measures of Hip Strength and Relation to Previous Injury in Collegiate Cross-Country Runners.

CONTEXT: Running-related injury occurs frequently in collegiate cross-country runners. Hip strength is one factor that may be important in the rehabilitation and training of cross-country runners. However, no normative values exist to inform these strategies. OBJECTIVE: To establish normative values for hip-abduction and external-rotation isometric strength in collegiate cross-country runners and explore the association between strength and previous injury. DESIGN: Mixed methods using descriptive epidemiology and retrospective cross-sectional designs. SETTING: University laboratory. PATIENTS OR OTHER PARTICIPANTS: Eighty-two National Collegiate Athletic Association Division III cross-country runners (38 males, 44 females). MAIN OUTCOME MEASURE(S): Isometric hip strength and reported injury. RESULTS: Males demonstrated greater absolute hip strength than females. Measures of hip strength were not different between sexes when normalized to height and mass. Hip-abduction asymmetry was associated with a previous injury in males. A combination of at least 1 leg with hip-abduction weakness and bilateral external-rotation weakness was associated with a previous injury in females. CONCLUSIONS: Knowledge of normative values of hip strength may help inform rehabilitation strategies in collegiate cross-country runners. Males and females may demonstrate different strength profiles after running-related injury.

Sex differences in gluteal muscle forces during running.

Sex differences in common sports injuries to the lower extremity have been reported. Biomechanical factors of the hip have been investigated between sexes with regard to running-related injury. This study investigates gluteal muscle forces between sexes to aid in our understanding of sex-related biomechanical factors in running. Twenty-one healthy male and female runners were participants. Each ran at a controlled speed of 3.52-3.89 m/s down a 20-m runway. Kinetic and kinematic data were utilised to estimate muscle forces. Multivariate analysis of variance tests were utilised to detect differences in gluteal and hamstring muscle forces, hip and pelvic kinematics, and hip kinetic variables between sexes. Males produced greater peak gluteus maximus force, but lesser peak gluteus medius, minimus, and hamstring force than females during running. Males also demonstrated less hip adduction and greater hip flexion and anterior pelvic tilt than females. Finally, males produced lesser peak hip abduction and external rotation moments than females. Males and females demonstrate differences in gluteal muscle forces and hip kinetics and kinematics during running. Further understanding of underlying muscle forces may offer further insight into biomechanical differences in running between males and females.

Effect of Hamstring-to-quadriceps Ratio on Knee Forces in Females During Landing.

ACL injuries in the athletic population are a common occurrence with over 70% associated with non-contact mechanisms. The hamstring to quadriceps ratio is a widely used clinical measure to assess an athlete's readiness to return to sport; however, its relationship to knee forces and ACL tension during landing is unknown. Baseline isokinetic testing was completed on 100 college-aged females. Subjects with strength ratios 0.4 (n=20) and those with ratios of 0.6 (n=20) returned for an assessment of their drop landing. A sagittal plane knee model determined the low ratio group demonstrated 16.6% larger ligament shear (p=0.000), a 26% increase in tibiofemoral shear force (p=0.026) and a 6% increase vertical force between the femur and tibial plateau (p=0.026) compared to the high hamstring ratio group within 100 ms upon impact. The lower ratio group also demonstrated 9.5% greater maximal quadriceps (p=0.028) force during landing. These findings suggest that the hamstring to quadriceps ratio may be related to knee forces and ACL loading during landing. This metric may augment clinical decision making regarding an athlete's readiness to return to sport or relative risk for re-injury.

Patellofemoral joint loading during the forward and backward lunge.

OBJECTIVE: To examine patellofemoral joint (PFJ) loading in two lunge movements: Forward Lunge (FL) and Backward Lunge (BL). DESIGN: Repeated Measures. SETTING: University Biomechanics Laboratory. PARTICIPANTS: 20 asymptomatic females. MAIN OUTCOME MEASURES: Six trials of two lunge movements (FL and BL) to a depth of 75% of leg length were performed. 3-D motion capture and force platforms were used to collect data as input into a musculoskeletal model to determine quadriceps force, PFJ reaction force, PFJ stress, and knee flexion angle. RESULTS: Multivariate analysis indicated differences in PFJ loading variables and joint angles between the lunge movements (Forward vs. Backward) and phases (Down vs. Up). Quadriceps force, PFJ reaction force, and knee flexion angle were larger in the FL movement and Up phases. PFJ loading rate was greater in the FL movement along with a lower forward trunk tilt. CONCLUSION: The FL produced greater PFJ loading variables compared to the BL. Further research is needed to examine a population of individuals who have patellofemoral pain (PFP) to see if their symptoms may be reduced when using the BL.

Relationship among maximum hip isometric strength, hip kinematics, and peak gluteal muscle force during running.

OBJECTIVE: To determine if there is a relationship among isometric hip strength, hip kinematics, and peak gluteal muscle forces in cross-country runners during running. DESIGN: Cross Sectional. SETTING: University Biomechanics Laboratory. PARTICIPANTS: Forty-six NCAA Division III collegiate cross-country runners (18 males, 28 females). MAIN OUTCOME MEASURES: Pearson correlation coefficients were used to describe relationships among isometric hip strength, hip kinematics, and peak gluteal muscle forces during the stance phase of running. Strength of correlations were interpreted as little to no relationship (r < 0.25), fair relationship (0.25 ≤ r < 0.5), moderate relationship (0.5 ≤ r < 0.75), and strong relationship (r ≥ 0.75). Correlations were considered significant if p < 0.05. RESULTS: Little to no relationships were found among isometric hip strength and gluteal muscle forces during running (r < 0.25). A fair relationship was present between prone external rotation isometric hip strength and peak hip adduction (0.25

Biomechanical risk factors for running-related injury differ by sample population: A systematic review and meta-analysis.

BACKGROUND: The role of biomechanical variables of running gait in the development of running related injury has not been clearly elucidated. Several systematic reviews have examined running biomechanics and its association with particular running related injuries. However, due to retrospective designs, inferences into the cause of these injuries are limited. Although prospective studies have been completed, no quantitative analysis pooling these results has been completed. METHODS: A systematic review of MEDLINE, CINAHL, and PubMed was completed. Articles included used prospective study designs, human subjects currently completing a regular running program, and a minimum 12-week follow-up period. Excluded articles had no biomechanical data reported, participants who were beginning runners or military recruits, or had an intervention provided. FINDINGS: Thirteen studies met these criteria. Pooled analyses were completed if two or more studies were available with samples that investigated the same sex and competition level. A qualitative synthesis was completed when pooled analysis was not possible. Five unique running samples were identified and allowed for pooled analyses of variables in mixed-sex collegiate runners and female recreational runners. Moderate evidence exists for increased hip adduction and reduced peak rearfoot eversion as risk factors for running related injury in female recreational runners. Variables differed in other samples of runners. INTERPRETATION: A runner's sex and competition level may affect the relationship between biomechanical factors and the development of running related injury. Hip adduction and rearfoot eversion may be important factors related to running related injury in female recreational runners. Further investigation of biomechanical factors in running injury is warranted.

Patellofemoral Joint Stress during Running with Added Load in Females.

Patellofemoral joint (PFJ) pain syndrome is a commonly reported form of pain in female runners and military personnel. Increased PFJ stress may be a contributing factor. Few studies have examined PFJ stress running with added load. Our purpose was to analyze PFJ stress, PFJ reaction force, quadriceps force, knee flexion angle, and other kinematic and temporospatial variables running with and without a 9 kg load. Nineteen females ran across a force platform with no added load and 9.0 kg weight vest. Kinematic data were collected using 3D motion capture and kinetic data with a force platform. Muscle forces were estimated using a musculoskeletal model, and peak PFJ loading variables were calculated during stance. Multivariate analyses were run on PFJ loading variables and on cadence, step length and foot strike index. Differences were shown in PFJ stress, PFJ reaction force, peak knee flexion angle and quadriceps force. Joint specific kinetic variables increased between 5-16% with added load. PFJ loading variables increased with 9 kg of added load without changes in cadence, step length, or foot strike index compared to no load. Added load appears to increase the PFJ loading variables associated with PFJ pain in running.