1.
Clin Toxicol (Phila)
; 59(1): 71-72, 2021 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32538692
Asunto(s)
Acetaminofén/envenenamiento , Acetilcisteína/uso terapéutico , Analgésicos no Narcóticos/envenenamiento , Antídotos/uso terapéutico , Sobredosis de Droga/tratamiento farmacológico , Fomepizol/uso terapéutico , Adulto , Sobredosis de Droga/sangre , Sobredosis de Droga/diagnóstico , Quimioterapia Combinada , Femenino , Humanos , Persona de Mediana Edad , Resultado del Tratamiento
2.
J Med Toxicol
; 4(2): 109-14, 2008 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18570172
RESUMEN
Intravenous fat emulsions (IFE) are traditionally used as a component of parenteral nutrition therapy. Recently, IFE was used to resuscitate severe local anesthetic drug toxicity. This review focuses on the potential role of IFE in treatment of toxicity due to local anesthetics and other lipid-soluble drugs. The general properties of IFE, metabolic fate, and associated adverse events are described. Cases of local anesthetic toxicity treated with IFE are presented along with a discussion of the possible antidotal mechanisms. Initial investigations into the antidotal use of IFE for lipophilic central nervous and cardiovascular drug toxicity are also reviewed.